SCOPe 2.05: Fold g.3: Knottins (small inhibitors, toxins, lectins)

Lineage for Fold g.3: Knottins (small inhibitors, toxins, lectins)

1. Root: SCOPe 2.05

2. Class g: Small proteins [56992] (92 folds)

3. Fold g.3: Knottins (small inhibitors, toxins, lectins) [57015] (19 superfamilies)
   disulfide-bound fold; contains beta-hairpin with two adjacent disulfides

Superfamilies:

1. g.3.1: Plant lectins/antimicrobial peptides [57016] (3 families)

2. g.3.2: Plant inhibitors of proteinases and amylases [57027] (1 family)

3. g.3.3: Cyclotides [57038] (4 families)
   macrocyclic plant knottins closed with the formation of an Asn-Gly peptide

4. g.3.4: Gurmarin-like [57048] (2 families)

5. g.3.5: Agouti-related protein [57055] (1 family)
   automatically mapped to Pfam PF05039

6. g.3.6: omega toxin-like [57059] (5 families)

7. g.3.7: Scorpion toxin-like [57095] (5 families)

8. g.3.8: Cellulose-binding domain [57180] (1 family)

9. g.3.9: Growth factor receptor domain [57184] (2 families)

10. g.3.10: Colipase-like [57190] (2 families)

11. g.3.11: EGF/Laminin [57196] (8 families)

12. g.3.12: Bromelain inhibitor VI (cysteine protease inhibitor) [57243] (1 family)

13. g.3.13: Bowman-Birk inhibitor, BBI [57247] (2 families)

14. g.3.14: Elafin-like [57256] (2 families)
    automatically mapped to Pfam PF00095

15. g.3.15: Leech antihemostatic proteins [57262] (3 families)

16. g.3.16: Granulin repeat [57277] (1 family)

17. g.3.17: Satiety factor CART (cocaine and amphetamine regulated transcript) [64546] (1 family)
    automatically mapped to Pfam PF06373

18. g.3.18: DPY module [90148] (1 family)

19. g.3.19: Bubble protein [103565] (1 family)
    automatically mapped to Pfam PF09227

More info for Fold g.3: Knottins (small inhibitors, toxins, lectins)

Timeline for Fold g.3: Knottins (small inhibitors, toxins, lectins):

• Fold g.3: Knottins (small inhibitors, toxins, lectins) first appeared (with stable ids) in SCOP 1.55
  
• Fold g.3: Knottins (small inhibitors, toxins, lectins) appears in SCOPe 2.04
  
• Fold g.3: Knottins (small inhibitors, toxins, lectins) appears in SCOPe 2.06
  
• Fold g.3: Knottins (small inhibitors, toxins, lectins) appears in the current release, SCOPe 2.08