SCOPe 2.06: Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain

Lineage for Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.162: LDH C-terminal domain-like [56326] (1 superfamily)
   unusual fold, defines family

4. Superfamily d.162.1: LDH C-terminal domain-like [56327] (3 families)

5. Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain [56328] (5 proteins)
   N-terminal domain is NAD-binding module (alpha/beta Rossmann-fold domain)
   automatically mapped to Pfam PF02866

Proteins:

1. L-2-hydroxyisocapronate dehydrogenase, L-HICDH [56337] (1 species)

   • Species Lactobacillus confusus [TaxId:1583] [56338] (1 PDB entry)

2. Lactate dehydrogenase [56339] (19 species)

   1. Species Archaeoglobus fulgidus [TaxId:2234] [111253] (4 PDB entries)
      Uniprot O08349

   2. Species Bacillus stearothermophilus [TaxId:1422] [56344] (3 PDB entries)

   3. Species Bifidobacterium longum, strain am101-2 [TaxId:216816] [56346] (2 PDB entries)

   4. Species Clostridium thermocellum [TaxId:1515] [118160] (1 PDB entry)
      Uniprot Q4CDK5

   5. Species Cryptosporidium parvum [TaxId:5807] [225186] (10 PDB entries)

   6. Species Dogfish (Squalus acanthias) [TaxId:7797] [56342] (3 PDB entries)

   7. Species Gallus gallus [TaxId:9031] [318261] (1 PDB entry)

   8. Species Human (Homo sapiens), heart isoform (H chain) [TaxId:9606] [64444] (2 PDB entries)

   9. Species Human (Homo sapiens), muscle isoform (M chain) [TaxId:9606] [64445] (16 PDB entries)

   10. Species Lactobacillus casei [TaxId:1582] [56345] (6 PDB entries)

   11. Species Lactobacillus pentosus [TaxId:1589] [69843] (1 PDB entry)

   12. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [56343] (14 PDB entries)

   13. Species Mouse (Mus musculus) [TaxId:10090] [56341] (1 PDB entry)

   14. Species Pig (Sus scrofa) [TaxId:9823] [56340] (3 PDB entries)

   15. Species Plasmodium berghei [TaxId:5821] [103325] (1 PDB entry)

   16. Species Plasmodium vivax [TaxId:5855] [225044] (3 PDB entries)

   17. Species Thermotoga maritima [TaxId:2336] [56347] (1 PDB entry)

   18. Species Thermus caldophilus [TaxId:272] [226615] (2 PDB entries)

   19. Species Toxoplasma gondii [TaxId:5811] [103326] (5 PDB entries)

3. Malate dehydrogenase [56329] (12 species)

   1. Species Aquaspirillum arcticum [TaxId:87645] [56336] (3 PDB entries)

   2. Species Chlorobium tepidum [TaxId:1097] [69841] (1 PDB entry)

   3. Species Chlorobium vibrioforme [TaxId:1098] [69842] (2 PDB entries)

   4. Species Chloroflexus aurantiacus [TaxId:1108] [69840] (7 PDB entries)
      Uniprot P80040

   5. Species Chloroflexus sp. [TaxId:480224] [236535] (1 PDB entry)

   6. Species Escherichia coli [TaxId:562] [56333] (4 PDB entries)

   7. Species Flaveria bidentis, chloroplast [TaxId:4224] [56332] (1 PDB entry)

   8. Species Haloarcula marismortui [TaxId:2238] [56335] (6 PDB entries)

   9. Species Pig (Sus scrofa) [TaxId:9823] [56330] (3 PDB entries)

   10. Species Sorghum (Sorghum vulgare), chloroplast [TaxId:4558] [56331] (1 PDB entry)

   11. Species Thermus flavus [TaxId:274] [56334] (2 PDB entries)

   12. Species Thermus thermophilus [TaxId:274] [82806] (7 PDB entries)
       identical sequence to that from the Thermus flavus enzyme

4. MJ0490, lactate/malate dehydrogenase [64446] (1 species)

   • Species Methanococcus jannaschii [TaxId:2190] [64447] (2 PDB entries)

5. automated matches [226882] (7 species)
   not a true protein

   1. Species Escherichia coli K-12 [TaxId:83333] [225274] (2 PDB entries)

   2. Species Haloarcula marismortui [TaxId:2238] [225148] (4 PDB entries)

   3. Species Human (Homo sapiens) [TaxId:9606] [225057] (8 PDB entries)

   4. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [254909] (5 PDB entries)

   5. Species Norway rat (Rattus norvegicus) [TaxId:10116] [226330] (13 PDB entries)

   6. Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [225719] (8 PDB entries)

   7. Species Toxoplasma gondii [TaxId:5811] [233101] (1 PDB entry)

More info for Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain

Timeline for Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain:

• Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain first appeared (with stable ids) in SCOP 1.55
  
• Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain appears in SCOPe 2.05
  
• Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain appears in SCOPe 2.07
  
• Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain appears in the current release, SCOPe 2.08