SCOPe 2.08: Domain d6wnks_: 6wnk S:

Lineage for d6wnks_ (6wnk S:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.153: Ntn hydrolase-like [56234] (2 superfamilies)
   4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing

4. Superfamily d.153.1: N-terminal nucleophile aminohydrolases (Ntn hydrolases) [56235] (8 families)
   N-terminal residue provides two catalytic groups, nucleophile and proton donor

5. Family d.153.1.4: Proteasome subunits [56251] (4 proteins)

6. Protein automated matches [190144] (14 species)
   not a true protein

7. Species Mycobacterium tuberculosis [TaxId:1773] [187707] (16 PDB entries)

8. Domain d6wnks_: 6wnk S: [403996]
   automated match to d5trgd_
   complexed with cit, dmf, u5y

Details for d6wnks_

PDB Entry: 6wnk, 2.28 Å

PDB Description: macrocyclic peptides tdi5575 that selectively inhibit the mycobacterium tuberculosis proteasome

PDB Compounds: (S:) Proteasome subunit alpha

SCOPe Domain Sequences for d6wnks_:

Sequence, based on SEQRES records:

>d6wnks_ d.153.1.4 (S:) automated matches {Mycobacterium tuberculosis [TaxId: 1773]}
meqamrerselarkgiaraksvvalayaggvlfvaenpsrslqkiselydrvgfaaagkf
nefdnlrrggiqfadtrgyaydrrdvtgrqlanvyaqtlgtifteqakpyevelcvaeva
hygetkrpelyritydgsiadephfvvmggttepianalkesyaenasltdalriavaal
ragsadtsggdqptlgvaslevavldanrprrafrritgsalqallvd

Sequence, based on observed residues (ATOM records):

>d6wnks_ d.153.1.4 (S:) automated matches {Mycobacterium tuberculosis [TaxId: 1773]}
meqamrerselarkgiaraksvvalayaggvlfvaenpsrslqkiselydrvgfaaagkf
nefdnlrrggiqfadtrgyaydrrdvtgrqlanvyaqtlgtifteqakpyevelcvaeva
hygetkrpelyritydgsiadephfvvmggttepianalkesyaenasltdalriavaal
ragslgvaslevavldanrprrafrritgsalqallvd

Timeline for d6wnks_:

• d6wnks_ first appeared in SCOPe 2.07