Lineage for Family d.153.1.4: Proteasome subunits

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2548740Fold d.153: Ntn hydrolase-like [56234] (2 superfamilies)
    4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing
  4. 2548741Superfamily d.153.1: N-terminal nucleophile aminohydrolases (Ntn hydrolases) [56235] (8 families) (S)
    N-terminal residue provides two catalytic groups, nucleophile and proton donor
  5. 2548925Family d.153.1.4: Proteasome subunits [56251] (4 protein domains)

Protein Domains:

  1. 2548926HslV (ClpQ) protease [56258] (4 species)
    dodecameric prokaryotic homologue of proteasome
    1. 2548927Species Bacillus subtilis [TaxId:1423] [160845] (2 PDB entries)
      Uniprot P39070 2-181
    2. 2548942Species Escherichia coli [TaxId:562] [56259] (8 PDB entries)
    3. 2548990Species Haemophilus influenzae [TaxId:727] [56260] (6 PDB entries)
    4. 2549033Species Thermotoga maritima [TaxId:2336] [90045] (1 PDB entry)
  2. 2549037Proteasome alpha subunit (non-catalytic) [56255] (9 species)
    contains an extension to the common fold at the N-terminus
    1. 2549038Species Archaeoglobus fulgidus [TaxId:2234] [90044] (2 PDB entries)
    2. 2549053Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [56257] (194 PDB entries)
      The structure of yeast proteasome complexed with the proteasome activator pa26 is available from PDB (1fnt). The 1FNT entry designates protein chains by both upper case and lower case letters creating problems with its processing and presentation in SCOP; the proteasome activator pa26 structure is classified elsewhere in SCOP (a.24.8)
    3. 2550450Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:559292] [256264] (12 PDB entries)
    4. 2550546Species Cow (Bos taurus) [TaxId:9913] [75568] (1 PDB entry)
    5. 2550561Species Human (Homo sapiens) [TaxId:9606] [311422] (8 PDB entries)
    6. 2550612Species Methanocaldococcus jannaschii [TaxId:2190] [346387] (1 PDB entry)
      3h4p lower case chains a-g are beta subunits; not included because sids are not case sensitive
    7. 2550620Species Mouse (Mus musculus) [TaxId:10090] [195927] (2 PDB entries)
    8. 2550625Species Rhodococcus erythropolis [TaxId:1833] [103314] (3 PDB entries)
    9. 2550647Species Thermoplasma acidophilum [TaxId:2303] [56256] (4 PDB entries)
  3. 2550690Proteasome beta subunit (catalytic) [56252] (7 species)
    1. 2550691Species Archaeoglobus fulgidus [TaxId:2234] [90043] (1 PDB entry)
    2. 2550699Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [56254] (175 PDB entries)
      The structure of yeast proteasome complexed with the proteasome activator pa26 is available from PDB (1fnt). The 1FNT entry designates protein chains by both upper case and lower case letters creating problems with its processing and presentation in SCOP; the proteasome activator pa26 structure is classified elsewhere in SCOP (a.24.8)
    3. 2552541Species Cow (Bos taurus) [TaxId:9913] [75567] (1 PDB entry)
    4. 2552556Species Human (Homo sapiens) [TaxId:9606] [311421] (8 PDB entries)
    5. 2552604Species Methanocaldococcus jannaschii [TaxId:2190] [346388] (1 PDB entry)
      3h4p upper case chains H-N are alpha subunits; not included because sids are not case sensitive
    6. 2552612Species Rhodococcus erythropolis [TaxId:1833] [103313] (3 PDB entries)
    7. 2552634Species Thermoplasma acidophilum [TaxId:2303] [56253] (6 PDB entries)
  4. 2552691automated matches [190144] (11 species)
    not a true protein
    1. 2552692Species Bacillus anthracis [TaxId:198094] [189742] (1 PDB entry)
    2. 2552699Species Bacillus subtilis [TaxId:1423] [187296] (1 PDB entry)
    3. 2552712Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [187078] (41 PDB entries)
    4. 2552960Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:559292] [189752] (156 PDB entries)
    5. 2554144Species Escherichia coli [311130] (1 PDB entry)
    6. 2554149Species Escherichia coli [TaxId:562] [326970] (1 PDB entry)
    7. 2554154Species Human (Homo sapiens) [TaxId:9606] [311423] (8 PDB entries)
    8. 2554220Species Mouse (Mus musculus) [TaxId:10090] [195917] (3 PDB entries)
    9. 2554266Species Mycobacterium tuberculosis [TaxId:1773] [187707] (14 PDB entries)
    10. 2554651Species Mycobacterium tuberculosis [TaxId:419947] [328158] (1 PDB entry)
    11. 2554678Species Thermoplasma acidophilum [TaxId:2303] [186869] (7 PDB entries)

More info for Family d.153.1.4: Proteasome subunits

Timeline for Family d.153.1.4: Proteasome subunits: