Lineage for Family d.153.1.4: Proteasome subunits

  1. Root: SCOPe 2.08
  2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)
  3. Fold d.153: Ntn hydrolase-like [56234] (2 superfamilies)
    4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing
  4. Superfamily d.153.1: N-terminal nucleophile aminohydrolases (Ntn hydrolases) [56235] (8 families) (S)
    N-terminal residue provides two catalytic groups, nucleophile and proton donor
  5. Family d.153.1.4: Proteasome subunits [56251] (4 proteins)

Proteins:

  1. HslV (ClpQ) protease [56258] (4 species)
    dodecameric prokaryotic homologue of proteasome
    1. Species Bacillus subtilis [TaxId:1423] [160845] (2 PDB entries)
      Uniprot P39070 2-181
    2. Species Escherichia coli [TaxId:562] [56259] (8 PDB entries)
    3. Species Haemophilus influenzae [TaxId:727] [56260] (6 PDB entries)
    4. Species Thermotoga maritima [TaxId:2336] [90045] (1 PDB entry)
  2. Proteasome alpha subunit (non-catalytic) [56255] (10 species)
    contains an extension to the common fold at the N-terminus
    1. Species Archaeoglobus fulgidus [TaxId:2234] [90044] (2 PDB entries)
    2. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [56257] (240 PDB entries)
      The structure of yeast proteasome complexed with the proteasome activator pa26 is available from PDB (1fnt). The 1FNT entry designates protein chains by both upper case and lower case letters creating problems with its processing and presentation in SCOP; the proteasome activator pa26 structure is classified elsewhere in SCOP (a.24.8)
    3. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:559292] [256264] (12 PDB entries)
    4. Species Cow (Bos taurus) [TaxId:9913] [75568] (1 PDB entry)
    5. Species Human (Homo sapiens) [TaxId:9606] [311422] (14 PDB entries)
    6. Species Methanocaldococcus jannaschii [TaxId:2190] [346387] (1 PDB entry)
      3h4p lower case chains a-g are beta subunits; not included because sids are not case sensitive
    7. Species Mouse (Mus musculus) [TaxId:10090] [195927] (2 PDB entries)
    8. Species Norway rat (Rattus norvegicus) [TaxId:10116] [385589] (1 PDB entry)
    9. Species Rhodococcus erythropolis [TaxId:1833] [103314] (3 PDB entries)
    10. Species Thermoplasma acidophilum [TaxId:2303] [56256] (8 PDB entries)
  3. Proteasome beta subunit (catalytic) [56252] (7 species)
    1. Species Archaeoglobus fulgidus [TaxId:2234] [90043] (1 PDB entry)
    2. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [56254] (202 PDB entries)
      The structure of yeast proteasome complexed with the proteasome activator pa26 is available from PDB (1fnt). The 1FNT entry designates protein chains by both upper case and lower case letters creating problems with its processing and presentation in SCOP; the proteasome activator pa26 structure is classified elsewhere in SCOP (a.24.8)
    3. Species Cow (Bos taurus) [TaxId:9913] [75567] (1 PDB entry)
    4. Species Human (Homo sapiens) [TaxId:9606] [311421] (14 PDB entries)
    5. Species Methanocaldococcus jannaschii [TaxId:2190] [346388] (1 PDB entry)
      3h4p upper case chains H-N are alpha subunits; not included because sids are not case sensitive
    6. Species Rhodococcus erythropolis [TaxId:1833] [103313] (3 PDB entries)
    7. Species Thermoplasma acidophilum [TaxId:2303] [56253] (7 PDB entries)
  4. automated matches [190144] (14 species)
    not a true protein
    1. Species Bacillus anthracis [TaxId:198094] [189742] (1 PDB entry)
    2. Species Bacillus subtilis [TaxId:1423] [187296] (1 PDB entry)
    3. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [187078] (41 PDB entries)
    4. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:559292] [189752] (202 PDB entries)
    5. Species Escherichia coli [311130] (1 PDB entry)
    6. Species Escherichia coli [TaxId:562] [326970] (1 PDB entry)
    7. Species Human (Homo sapiens) [TaxId:9606] [311423] (24 PDB entries)
    8. Species Mouse (Mus musculus) [TaxId:10090] [195917] (3 PDB entries)
    9. Species Mycobacterium tuberculosis [TaxId:1773] [187707] (15 PDB entries)
    10. Species Mycobacterium tuberculosis [TaxId:419947] [328158] (1 PDB entry)
    11. Species Mycobacterium tuberculosis [TaxId:83332] [375714] (3 PDB entries)
    12. Species Norway rat (Rattus norvegicus) [TaxId:10116] [385575] (1 PDB entry)
    13. Species Staphylococcus aureus [TaxId:158878] [389232] (2 PDB entries)
    14. Species Thermoplasma acidophilum [TaxId:2303] [186869] (4 PDB entries)

More info for Family d.153.1.4: Proteasome subunits

Timeline for Family d.153.1.4: Proteasome subunits: