SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family d.153.1.4: Proteasome subunits

  1. Root: SCOPe 2.06
  2. 2152203Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2201124Fold d.153: Ntn hydrolase-like [56234] (2 superfamilies)
    4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing
  4. 2201125Superfamily d.153.1: N-terminal nucleophile aminohydrolases (Ntn hydrolases) [56235] (8 families) (S)
    N-terminal residue provides two catalytic groups, nucleophile and proton donor
  5. 2201309Family d.153.1.4: Proteasome subunits [56251] (4 protein domains)

Protein Domains:

  1. 2201310HslV (ClpQ) protease [56258] (4 species)
    dodecameric prokaryotic homologue of proteasome
    1. 2201311Species Bacillus subtilis [TaxId:1423] [160845] (2 PDB entries)
      Uniprot P39070 2-181
    2. 2201326Species Escherichia coli [TaxId:562] [56259] (8 PDB entries)
    3. 2201374Species Haemophilus influenzae [TaxId:727] [56260] (6 PDB entries)
    4. 2201417Species Thermotoga maritima [TaxId:2336] [90045] (1 PDB entry)
  2. 2201421Proteasome alpha subunit (non-catalytic) [56255] (8 species)
    contains an extension to the common fold at the N-terminus
    1. 2201422Species Archaeoglobus fulgidus [TaxId:2234] [90044] (2 PDB entries)
    2. 2201437Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [56257] (191 PDB entries)
      The structure of yeast proteasome complexed with the proteasome activator pa26 is available from PDB (1fnt). The 1FNT entry designates protein chains by both upper case and lower case letters creating problems with its processing and presentation in SCOP; the proteasome activator pa26 structure is classified elsewhere in SCOP (a.24.8)
    3. 2202407Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:559292] [256264] (12 PDB entries)
    4. 2202409Species Cow (Bos taurus) [TaxId:9913] [75568] (1 PDB entry)
    5. 2202424Species Human (Homo sapiens) [TaxId:9606] [311422] (8 PDB entries)
    6. 2202447Species Mouse (Mus musculus) [TaxId:10090] [195927] (2 PDB entries)
    7. 2202452Species Rhodococcus erythropolis [TaxId:1833] [103314] (3 PDB entries)
    8. 2202474Species Thermoplasma acidophilum [TaxId:2303] [56256] (3 PDB entries)
  3. 2202517Proteasome beta subunit (catalytic) [56252] (6 species)
    1. 2202518Species Archaeoglobus fulgidus [TaxId:2234] [90043] (1 PDB entry)
    2. 2202526Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [56254] (172 PDB entries)
      The structure of yeast proteasome complexed with the proteasome activator pa26 is available from PDB (1fnt). The 1FNT entry designates protein chains by both upper case and lower case letters creating problems with its processing and presentation in SCOP; the proteasome activator pa26 structure is classified elsewhere in SCOP (a.24.8)
    3. 2203808Species Cow (Bos taurus) [TaxId:9913] [75567] (1 PDB entry)
    4. 2203823Species Human (Homo sapiens) [TaxId:9606] [311421] (8 PDB entries)
    5. 2203841Species Rhodococcus erythropolis [TaxId:1833] [103313] (3 PDB entries)
    6. 2203863Species Thermoplasma acidophilum [TaxId:2303] [56253] (5 PDB entries)
  4. 2203920automated matches [190144] (11 species)
    not a true protein
    1. 2203921Species Bacillus anthracis [TaxId:198094] [189742] (1 PDB entry)
    2. 2203928Species Bacillus subtilis [TaxId:1423] [187296] (1 PDB entry)
    3. 2203941Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [187078] (41 PDB entries)
    4. 2204191Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:559292] [189752] (155 PDB entries)
    5. 2204860Species Escherichia coli [311130] (1 PDB entry)
    6. 2204865Species Human (Homo sapiens) [TaxId:9606] [311423] (8 PDB entries)
    7. 2204879Species Mouse (Mus musculus) [TaxId:10090] [195917] (3 PDB entries)
    8. 2204923Species Mycobacterium tuberculosis [TaxId:1773] [187707] (14 PDB entries)
    9. 2205178Species Thermoplasma acidophilum [TaxId:2303] [186869] (7 PDB entries)
    10. 2283669Species Escherichia coli [TaxId:562] [326970] (1 PDB entry)
    11. 2284857Species Mycobacterium tuberculosis [TaxId:419947] [328158] (1 PDB entry)

More info for Family d.153.1.4: Proteasome subunits

Timeline for Family d.153.1.4: Proteasome subunits: