SCOPe 2.08: Domain d6yvya_: 6yvy A:

Lineage for d6yvya_ (6yvy A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Focal adhesion kinase 1 (fak) [103292] (2 species)
   PTK group; FAK subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [103293] (23 PDB entries)

8. Domain d6yvya_: 6yvy A: [401350]
   automated match to d2etmb_
   complexed with p1e, so4

Details for d6yvya_

PDB Entry: 6yvy, 1.92 Å

PDB Description: focal adhesion kinase catalytic domain in complex with 4-{[4-{[(1r, 2r)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin- 2-yl]amino}-n-methylbenzenesulfonamide

PDB Compounds: (A:) Focal adhesion kinase 1

SCOPe Domain Sequences for d6yvya_:

Sequence, based on SEQRES records:

>d6yvya_ d.144.1.7 (A:) Focal adhesion kinase 1 (fak) {Human (Homo sapiens) [TaxId: 9606]}
trdyeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrekflqe
altmrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayqls
talayleskrfvhrdiaarnvlvssndcvklgdfglsrymedstyykaskgklpikwmap
esinfrrftsasdvwmfgvcmweilmhgvkpfqgvknndvigriengerlpmppncpptl
yslmtkcwaydpsrrprftelkaqlstileeekaq

Sequence, based on observed residues (ATOM records):

>d6yvya_ d.144.1.7 (A:) Focal adhesion kinase 1 (fak) {Human (Homo sapiens) [TaxId: 9606]}
trdyeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrekflqe
altmrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayqls
talayleskrfvhrdiaarnvlvssndcvklgdfglsrymgklpikwmapesinfrrfts
asdvwmfgvcmweilmhgvkpfqgvknndvigriengerlpmppncpptlyslmtkcway
dpsrrprftelkaqlstileeekaq

Timeline for d6yvya_:

• d6yvya_ first appeared in SCOPe 2.07