SCOPe 2.08: Domain d6sdca_: 6sdc A:

Lineage for d6sdca_ (6sdc A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Hepatocyte growth factor receptor, c-MET [103300] (1 species)
   PTK group; HGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [103301] (67 PDB entries)

8. Domain d6sdca_: 6sdc A: [373051]
   automated match to d4eeva_
   complexed with 88z

Details for d6sdca_

PDB Entry: 6sdc, 1.67 Å

PDB Description: crystal structure of d1228v cmet bound by foretinib

PDB Compounds: (A:) Hepatocyte growth factor receptor

SCOPe Domain Sequences for d6sdca_:

Sequence, based on SEQRES records:

>d6sdca_ d.144.1.7 (A:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
hidlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihcavks
lnritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfirn
ethnptvkdligfglqvakgmkylaskkfvhrdlaarncmldekftvkvadfglarvmyd
keyysvhnktgaklpvkwmaleslqtqkfttksdvwsfgvllwelmtrgappypdvntfd
itvyllqgrrllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfig

Sequence, based on observed residues (ATOM records):

>d6sdca_ d.144.1.7 (A:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
hidlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldgkkihcavksln
ritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfirnhn
ptvkdligfglqvakgmkylaskkfvhrdlaarncmldekftvkvadfglarvmydkeyy
svaklpvkwmaleslqtqkfttksdvwsfgvllwelmtrgappypdvntfditvyllqgr
rllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfig

Timeline for d6sdca_:

• d6sdca_ first appeared in SCOPe 2.07