SCOPe 2.08: Domain d6ne5d_: 6ne5 D:

Lineage for d6ne5d_ (6ne5 D:)

1. Root: SCOPe 2.08

2. Class f: Membrane and cell surface proteins and peptides [56835] (69 folds)

3. Fold f.1: Toxins' membrane translocation domains [56836] (5 superfamilies)
   multi-helical domains of various folds which is thought to unfold in the membrane

4. Superfamily f.1.4: Bcl-2 inhibitors of programmed cell death [56854] (2 families)
   PROVISIONAL CLASSIFICATION, based on structural similarity to the diphtheria toxin domain

5. Family f.1.4.1: Bcl-2 inhibitors of programmed cell death [56855] (11 proteins)
   Pfam PF00452

6. Protein EAT/MCL-1 (Myeloid cell leukemia sequence 1) [118212] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [188549] (62 PDB entries)

8. Domain d6ne5d_: 6ne5 D: [367859]
   automated match to d2kbwa_
   complexed with kjp

Details for d6ne5d_

PDB Entry: 6ne5, 1.85 Å

PDB Description: discovery of potent myeloid cell leukemia-1 (mcl-1) inhibitors that demonstrate in vivo activity in mouse xenograft models of human cancer

PDB Compounds: (D:) Induced myeloid leukemia cell differentiation protein Mcl-1

SCOPe Domain Sequences for d6ne5d_:

Sequence, based on SEQRES records:

>d6ne5d_ f.1.4.1 (D:) EAT/MCL-1 (Myeloid cell leukemia sequence 1) {Human (Homo sapiens) [TaxId: 9606]}
delyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqgm
lrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciepla
esitdvlvrtkrdwlvkqrgwdgfveffhv

Sequence, based on observed residues (ATOM records):

>d6ne5d_ f.1.4.1 (D:) EAT/MCL-1 (Myeloid cell leukemia sequence 1) {Human (Homo sapiens) [TaxId: 9606]}
delyrqsleiisrylreqatgakdtkpmsgatsrkaletlrrvgdgvqrnhetafqgmlr
kldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqescieplaes
itdvlvrtkrdwlvkqrgwdgfveffhv

Timeline for d6ne5d_:

• d6ne5d_ first appeared in SCOPe 2.07