SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family f.1.4.1: Bcl-2 inhibitors of programmed cell death

  1. Root: SCOPe 2.06
  2. 2223823Class f: Membrane and cell surface proteins and peptides [56835] (59 folds)
  3. 2223824Fold f.1: Toxins' membrane translocation domains [56836] (5 superfamilies)
    multi-helical domains of various folds which is thought to unfold in the membrane
  4. 2223896Superfamily f.1.4: Bcl-2 inhibitors of programmed cell death [56854] (2 families) (S)
    PROVISIONAL CLASSIFICATION, based on structural similarity to the diphtheria toxin domain
  5. 2223897Family f.1.4.1: Bcl-2 inhibitors of programmed cell death [56855] (11 protein domains)
    Pfam PF00452

Protein Domains:

  1. 2223898Apoptosis regulator Bcl-w [90103] (1 species)
  2. 2223903Apoptosis regulator Bcl-xL [56856] (3 species)
    1. 2223904Species Human (Homo sapiens) [TaxId:9606] [56857] (33 PDB entries)
    2. 2223954Species Mouse (Mus musculus) [TaxId:10090] [103423] (9 PDB entries)
    3. 2223968Species Norway rat (Rattus norvegicus) [TaxId:10116] [56858] (1 PDB entry)
  3. 2223970Apoptosis regulator ced-9 [103424] (1 species)
  4. 2223976Bcl-2 [64524] (1 species)
  5. 2223993Bcl-2 homolog [75637] (1 species)
  6. 2223996Bcl-2 homolog V-bcl-2 [144081] (1 species)
  7. 2224003Early antigen protein R [103426] (1 species)
  8. 2224006EAT/MCL-1 (Myeloid cell leukemia sequence 1) [118212] (3 species)
    1. 2224007Species Human (Homo sapiens) [TaxId:9606] [188549] (1 PDB entry)
    2. 2224009Species Mouse (Mus musculus) [TaxId:10090] [118213] (5 PDB entries)
      Uniprot P97287 152-308
    3. 2224015Species Norway rat (Rattus norvegicus) [TaxId:10116] [187917] (2 PDB entries)
  9. 2224018Proapoptotic molecule Bax [56862] (1 species)
  10. 2224022Proapoptotic molecule Bid [56859] (2 species)
    1. 2224023Species Human (Homo sapiens) [TaxId:9606] [56860] (1 PDB entry)
    2. 2224025Species Mouse (Mus musculus) [TaxId:10090] [56861] (1 PDB entry)
  11. 2224027automated matches [190236] (4 species)
    not a true protein
    1. 2224028Species Human (Homo sapiens) [TaxId:9606] [188722] (46 PDB entries)
    2. 2224142Species Mouse (Mus musculus) [TaxId:10090] [187004] (1 PDB entry)
    3. 2224144Species Nematode (Caenorhabditis elegans) [TaxId:6239] [255025] (1 PDB entry)
    4. 2284733Species Mus musculus, [TaxId:10090] [328034] (1 PDB entry)

More info for Family f.1.4.1: Bcl-2 inhibitors of programmed cell death

Timeline for Family f.1.4.1: Bcl-2 inhibitors of programmed cell death: