SCOPe 2.07: Domain d5twna_: 5twn A:

Lineage for d5twna_ (5twn A:)

1. Root: SCOPe 2.07

2. Class e: Multi-domain proteins (alpha and beta) [56572] (71 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (8 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein automated matches [190260] (25 species)
   not a true protein

7. Species Hepatitis C virus genotype 1b (isolate con1) [TaxId:333284] [188792] (8 PDB entries)

8. Domain d5twna_: 5twn A: [331358]
   automated match to d3q0za_
   protein/RNA complex; complexed with 23e, 7ng, so4

Details for d5twna_

PDB Entry: 5twn, 3.04 Å

PDB Description: crystal structure of the hepatitis c virus ns5b rna- dependent rna polymerase in complex with 5-[3-(tert-butylcarbamoyl)phenyl]-6- (ethylamino)-2-(4-fluorophenyl)-n-methylfuro[2,3-b]pyridine-3- carboxamide

PDB Compounds: (A:) ns5b RNA- dependent RNA polymerase

SCOPe Domain Sequences for d5twna_:

Sequence, based on SEQRES records:

>d5twna_ e.8.1.4 (A:) automated matches {Hepatitis C virus genotype 1b (isolate con1) [TaxId: 333284]}
smsytwtgalitpcaaeetklpinalsnsllrhhnlvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsarskfgygakdvrnlsskavnhir
svwkdlledtetpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqavmgssygfqyspgqrveflvnawkakkcpmgfaydtrcfdstvtendirveesiy
qccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkaa
aacraaklqdctmlvcgddlvvicesagtqedeaslrafteamtrysappgdppkpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiiqrlhglsafslhsyspg
einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavrtklkltpip
aasqldlsswfvagysggdiyhslsrarprwfm

Sequence, based on observed residues (ATOM records):

>d5twna_ e.8.1.4 (A:) automated matches {Hepatitis C virus genotype 1b (isolate con1) [TaxId: 333284]}
smsytwtgalitpcyattsrsaslrqkkvtfdrlqvlddhyrdvlkemkakastvkakll
sveeackltpphsarskfgygakdvrnlsskavnhirsvwkdlledtetpidttimakne
vfcvqpekggrkparlivfpdlgvrvcekmalydvvstlpqavmgssygfqyspgqrvef
lvnawkakkcpmgfaydtrcfdstvtendirveesiyqccdlapearqairslterlyig
gpltnskgqncgyrrcrasgvlttscgntltcylkaaaacraaklqdctmlvcgddlvvi
cesagtqedeaslrafteamtrysappgdppkpeydlelitscssnvsvahdasgkrvyy
ltrdpttplaraawetarhtpvnswlgniimyaptlwarmilmthffsillaqeqlekal
dcqiygacysiepldlpqiiqrlhglsafslhsyspgeinrvasclrklgvpplrvwrhr
arsvrarllsqggraatcgkylfnwavrtklkltpipaasqldlsswfvagysggdiyhs
lsrarprwfm

Timeline for d5twna_:

• d5twna_ first appeared in SCOPe 2.06
  
• d5twna_ appears in the current release, SCOPe 2.08