SCOPe 2.06: Domain d4n9zb_: 4n9z B:

Lineage for d4n9zb_ (4n9z B:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.50: Macro domain-like [52948] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 6 strands, order 165243, strand 3 is antiparallel to the rest

4. Superfamily c.50.1: Macro domain-like [52949] (4 families)

5. Family c.50.1.3: Poly(ADP-ribose) glycohydrolase (PARG) catalytic domain-like [310642] (2 proteins)
   Pfam PF05028
   Contains N- and C-terminal extensions to macrodomain, including Tyr clasp, discussed in PubMed 22609859

6. Protein Poly(ADP-ribose) glycohydrolase (PARG) catalytic domain [310785] (3 species)

7. Species Mouse (Mus musculus) [TaxId:10090] [311376] (7 PDB entries)

8. Domain d4n9zb_: 4n9z B: [307756]
   automated match to d3ueka_
   complexed with so4, v3l; mutant

Details for d4n9zb_

PDB Entry: 4n9z, 1.9 Å

PDB Description: Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain mutant E749Q

PDB Compounds: (B:) Poly(ADP-ribose) glycohydrolase

SCOPe Domain Sequences for d4n9zb_:

Sequence, based on SEQRES records:

>d4n9zb_ c.50.1.3 (B:) Poly(ADP-ribose) glycohydrolase (PARG) catalytic domain {Mouse (Mus musculus) [TaxId: 10090]}
pekkwlgtpieemrkmprcgihlpslrpsashtvtvrvdllragevpkpfpthykdlwdn
khvkmpcseqnlypvedengertagsrweliqtallnkftrpqnlkdailkynvayskkw
dftalvdfwdkvleeaeaqhlyqsilpdmvkialclpnictqpipllkqkmnhsvtmsqe
qiasllanaffctfprrnakmkseyssypdinfnrlfegrssrkpeklktlfcyfrrvte
kkptglvtftrqsledfpewercekpltrlhvtyegtiegngrgmlqvdfanrfvgggvt
gaglvqeqirflinpelivsrlftevldhnecliitgteqyseytgyaetyrwarshedg
sekddwqrrcteivaidalhfrryldqfvpekvrrelnkaycgflrpgvpsenlsavatg
nwgcgafggdarlkaliqilaaaaaerdvvyftfgdselmrdiysmhtflterkldvgkv
yklllryyneecrncstpgpdiklypfiyhavessa

Sequence, based on observed residues (ATOM records):

>d4n9zb_ c.50.1.3 (B:) Poly(ADP-ribose) glycohydrolase (PARG) catalytic domain {Mouse (Mus musculus) [TaxId: 10090]}
pekkwlgtpieemrkmprcgihlpslrpsashtvtvrvdllragevpkpfpthykdlwdn
khvkmpcseqnlyptagsrweliqtallnkftrpqnlkdailkynvayskkwdftalvdf
wdkvleeaeaqhlyqsilpdmvkialclpnictqpipllkqkmnhsvtmsqeqiasllan
affctfprrnakmkseyssypdinfnrlfegrssrkpeklktlfcyfrrvtekkptglvt
ftrqsledfpewercekpltrlhvtyegtiegngrgmlqvdfanrfvgggvtgaglvqeq
irflinpelivsrlftevldhnecliitgteqyseytgyaetyrwarshedgsekddwqr
rcteivaidalhfrryldqfvpekvrrelnkaycgflrpgvpsenlsavatgnwgcgafg
gdarlkaliqilaaaaaerdvvyftfgdselmrdiysmhtflterkldvgkvyklllryy
neecrncstpgpdiklypfiyhavessa

Timeline for d4n9zb_:

• d4n9zb_ is new in SCOPe 2.06-stable
  
• d4n9zb_ appears in SCOPe 2.07
  
• d4n9zb_ appears in the current release, SCOPe 2.08