SCOPe 2.06: Domain d4tw9a_: 4tw9 A:

Lineage for d4tw9a_ (4tw9 A:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Casein kinase-1, CK1 [56139] (4 species)
   OPK group; CKI subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [224941] (14 PDB entries)

8. Domain d4tw9a_: 4tw9 A: [258555]
   automated match to d1ckia_
   complexed with 386, cl, hsj, na, so4

Details for d4tw9a_

PDB Entry: 4tw9, 2.4 Å

PDB Description: difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of ck1delta and epsilon with nanomolar inhibitory activity on cancer cell proliferation

PDB Compounds: (A:) Casein kinase I isoform delta

SCOPe Domain Sequences for d4tw9a_:

Sequence, based on SEQRES records:

>d4tw9a_ d.144.1.7 (A:) Casein kinase-1, CK1 {Human (Homo sapiens) [TaxId: 9606]}
elrvgnryrlgnkigsgsfgdiylgtdiaageevaiklecvktkhpqlhieskiykmmqg
gvgiptirwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihs
knfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtaryas
inthlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlc
kgypsefatylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlkf

Sequence, based on observed residues (ATOM records):

>d4tw9a_ d.144.1.7 (A:) Casein kinase-1, CK1 {Human (Homo sapiens) [TaxId: 9606]}
elrvgnryrlgnkigsgsfgdiylgtdiaageevaiklecvktkhpqlhieskiykmmqg
gvgiptirwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihs
knfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtaryas
inthlgieqsrrddleslgyvlmyfnlgslpwqglkaakyerisekkmstpievlckgyp
sefatylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlkf

Timeline for d4tw9a_:

• d4tw9a_ first appeared in SCOPe 2.04
  
• d4tw9a_ appears in SCOPe 2.05
  
• d4tw9a_ appears in SCOPe 2.07
  
• d4tw9a_ appears in the current release, SCOPe 2.08