SCOPe 2.05: Domain d4bcfa_: 4bcf A:

Lineage for d4bcfa_ (4bcf A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (12 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (553 PDB entries)

8. Domain d4bcfa_: 4bcf A: [251194]
   Other proteins in same PDB: d4bcfb1, d4bcfb2
   automated match to d4imya_
   complexed with t6q

Details for d4bcfa_

PDB Entry: 4bcf, 3.01 Å

PDB Description: structure of cdk9 in complex with cyclin t and a 2-amino-4-heteroaryl- pyrimidine inhibitor

PDB Compounds: (A:) Cyclin-dependent kinase 9

SCOPe Domain Sequences for d4bcfa_:

Sequence, based on SEQRES records:

>d4bcfa_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dsvecpfcdevskyeklakigqgtfgevfkarhrktgqkvalkkvlmenekegfpitalr
eikilqllkhenvvnlieicrtkaspynrckasiylvfdfcehdlagllsnvlvkftlse
ikrvmqmllnglyyihrnkilhrdmkaanvlitrdgvlkladfglarafslaknsqpnry
tnrvvtlwyrppelllgerdygppidlwgagcimaemwtrspimqgnteqhqlalisqlc
gsitpevwpnvdnyelyeklelvkgqkrkvkdrlkayvrdpyaldlidkllvldpaqrid
sddalnhdffwsdpmpsdlkg

Sequence, based on observed residues (ATOM records):

>d4bcfa_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dsvecpfcdevskyeklakigqgtfgevfkarhrktgqkvalkkvlmenekegfpitalr
eikilqllkhenvvnlieicrtkasiylvfdfcehdlagllsnvlvkftlseikrvmqml
lnglyyihrnkilhrdmkaanvlitrdgvlkladfglarafslpnrytnrvvtlwyrppe
lllgerdygppidlwgagcimaemwtrspimqgnteqhqlalisqlcgsitpevwpnvdn
yelyeklelvkgqkrkvkdrlkayvrdpyaldlidkllvldpaqridsddalnhdffwsd
pmpsdlkg

Timeline for d4bcfa_:

• d4bcfa_ first appeared in SCOPe 2.04
  
• d4bcfa_ appears in SCOPe 2.06
  
• d4bcfa_ appears in the current release, SCOPe 2.08