PDB entry 4bcf
View 4bcf on RCSB PDB site
Description: Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor
Class: transferase/cell cycle
Keywords: transferase-cell cycle complex, cdk-cyclin complex, transcription-protein binding, structure-based drug design
Deposited on
2012-10-02, released
2013-01-09
The last revision prior to the SCOPe 2.05 freeze date was dated
2013-02-27, with a file datestamp of
2013-02-22.
Experiment type: XRAY
Resolution: 3.01 Å
R-factor: 0.169
AEROSPACI score: 0.29
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Cyclin-dependent kinase 9
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d4bcfa_ - Chain 'B':
Compound: Cyclin-T1
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot O60563 (Start-259)
- engineered mutation (77)
- engineered mutation (96)
- engineered mutation (241)
Domains in SCOPe 2.05: d4bcfb1, d4bcfb2 - Heterogens: T6Q, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4bcfA (A:)
gpakqydsvecpfcdevskyeklakigqgtfgevfkarhrktgqkvalkkvlmenekegf
pitalreikilqllkhenvvnlieicrtkaspynrckasiylvfdfcehdlagllsnvlv
kftlseikrvmqmllnglyyihrnkilhrdmkaanvlitrdgvlkladfglarafslakn
sqpnrytnrvvtlwyrppelllgerdygppidlwgagcimaemwtrspimqgnteqhqla
lisqlcgsitpevwpnvdnyelyeklelvkgqkrkvkdrlkayvrdpyaldlidkllvld
paqridsddalnhdffwsdpmpsdlkgmlst
Sequence, based on observed residues (ATOM records): (download)
>4bcfA (A:)
dsvecpfcdevskyeklakigqgtfgevfkarhrktgqkvalkkvlmenekegfpitalr
eikilqllkhenvvnlieicrtkasiylvfdfcehdlagllsnvlvkftlseikrvmqml
lnglyyihrnkilhrdmkaanvlitrdgvlkladfglarafslpnrytnrvvtlwyrppe
lllgerdygppidlwgagcimaemwtrspimqgnteqhqlalisqlcgsitpevwpnvdn
yelyeklelvkgqkrkvkdrlkayvrdpyaldlidkllvldpaqridsddalnhdffwsd
pmpsdlkg
- Chain 'B':
Sequence, based on SEQRES records: (download)
>4bcfB (B:)
gpegerknnnkrwyftreqlenspsrrfgvdpdkelsyrqqaanllqdmgqrlnvsqlti
ntaivymhrfymiqsftrfpgnsvapaalflaakvegqpkklehvikvahtclhpqeslp
dtrseaylqqvqdlvilesiilqtlgfeltidhphthvvkctqlvraskdlaqtsyfmat
nslhlttfslqytppvvacvcihlackwsnweipvstdgkhwweyvdatvtlelldelth
ellqilektpnrlkriwnwr
Sequence, based on observed residues (ATOM records): (download)
>4bcfB (B:)
nnkrwyftreqlenspsrrfgvdpdkelsyrqqaanllqdmgqrlnvsqltintaivymh
rfymiqsftrfpgnsvapaalflaakvegqpkklehvikvahtclhpqeslpdtrseayl
qqvqdlvilesiilqtlgfeltidhphthvvkctqlvraskdlaqtsyfmatnslhlttf
slqytppvvacvcihlackwsnweipvstdgkhwweyvdatvtlelldelthellqilek
tpnrlkriwnwr