SCOPe 2.05: Domain d4mk7b_: 4mk7 B:

Lineage for d4mk7b_ (4mk7 B:)

1. Root: SCOPe 2.05

2. Class e: Multi-domain proteins (alpha and beta) [56572] (68 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein Viral RNA polymerase [56695] (17 species)

7. Species Hepatitis C virus [TaxId:11103] [56697] (72 PDB entries)

8. Domain d4mk7b_: 4mk7 B: [228252]
   automated match to d3mf5a_
   complexed with 28o, dms, mg

Details for d4mk7b_

PDB Entry: 4mk7, 2.8 Å

PDB Description: Hepatitis C Virus polymerase NS5B genotype 1b (BK) in complex with inhibitor 2 (3-(3-tert-butyl-4-methoxyphenyl)pyridin-2(1H)-one)

PDB Compounds: (B:) RNA-directed RNA polymerase

SCOPe Domain Sequences for d4mk7b_:

Sequence, based on SEQRES records:

>d4mk7b_ e.8.1.4 (B:) Viral RNA polymerase {Hepatitis C virus [TaxId: 11103]}
hmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpip
aasrldlsgwfvagysggdiyh

Sequence, based on observed residues (ATOM records):

>d4mk7b_ e.8.1.4 (B:) Viral RNA polymerase {Hepatitis C virus [TaxId: 11103]}
hmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqggrkparlivfpdlgvrvcekmalydvvstlp
qvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqcc
dlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaac
raaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydleli
tscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarm
ilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgein
rvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipaas
rldlsgwfvagysggdiyh

Timeline for d4mk7b_:

• d4mk7b_ first appeared in SCOPe 2.03
  
• d4mk7b_ appears in SCOPe 2.04
  
• d4mk7b_ is called d4mk7b1 in SCOPe 2.06
  
• d4mk7b_ appears in the current release, SCOPe 2.08, called d4mk7b1