SCOPe 2.05: Domain d4aoyc_: 4aoy C:

Lineage for d4aoyc_ (4aoy C:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families)
   the constituent families form similar dimers

5. Family c.77.1.0: automated matches [191423] (1 protein)
   not a true family

6. Protein automated matches [190603] (14 species)
   not a true protein

7. Species Clostridium thermocellum [TaxId:1515] [192994] (2 PDB entries)

8. Domain d4aoyc_: 4aoy C: [192999]
   automated match to d2uxqa_

Details for d4aoyc_

PDB Entry: 4aoy, 2.35 Å

PDB Description: open ctidh. the complex structures of isocitrate dehydrogenase from clostridium thermocellum and desulfotalea psychrophila, support a new active site locking mechanism

PDB Compounds: (C:) Isocitrate dehydrogenase [NADP]

SCOPe Domain Sequences for d4aoyc_:

Sequence, based on SEQRES records:

>d4aoyc_ c.77.1.0 (C:) automated matches {Clostridium thermocellum [TaxId: 1515]}
skikmkvplvemdgdemtriiwrlikenllepyielnteyydlglenrdktedqvtidaa
raiqkygvgvkcatitpnaqrveeynlkkmwkspngtiraildgtvfrapivvnsikpfv
kgwkkpisiarhaygdvyknveyyvpsagkaelvftsengevsrqtihefdgpgvimgmh
ntdksirsfaracfnyaldmnqdlwfstkdtisktydhrfkdifqeiyeneykekfeakn
lqyfytliddavariirseggmvwacknydgdvmsdmvasafgslammtsvlvspdgkye
feaahgtvtrhyykhlkgeetstnsmatifawtgalkkrgeldgikelvdfatkleqasv
qtiengvmtkdlaslsevpekkivntedflkeirktfegm

Sequence, based on observed residues (ATOM records):

>d4aoyc_ c.77.1.0 (C:) automated matches {Clostridium thermocellum [TaxId: 1515]}
skikmkvplvemdgdemtriiwrlikenllepyielnteyydlglenrdktedqvtidaa
raiqkygvgvkcatitpnaqrveeynlkkmwkspngtiraildgtvfrapivvnsikpfv
kgwkkpisiarhnveyyvpsagkaelvftsengevsrqtihefdgpgvimgmhntdksir
sfaracfnyaldmnqdlwfstkdtisktydhrfkdifqeiyeneykekfeaknlqyfytl
iddavariirseggmvwackndvmsdmvasafgslammtsvlvspdgkyefeaansmati
fawtgalkkrgeldgikelvdfatkleqasvqtiengvmtkdlaslsevpekkivntedf
lkeirktfegm

Timeline for d4aoyc_:

• d4aoyc_ first appeared in SCOPe 2.02
  
• d4aoyc_ appears in SCOPe 2.04
  
• d4aoyc_ appears in SCOPe 2.06
  
• d4aoyc_ appears in the current release, SCOPe 2.08