SCOPe 2.07: Domain d3h98b1: 3h98 B:2-563

Lineage for d3h98b1 (3h98 B:2-563)

1. Root: SCOPe 2.07

2. Class e: Multi-domain proteins (alpha and beta) [56572] (71 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (8 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein automated matches [190260] (25 species)
   not a true protein

7. Species Hepatitis C virus genotype 1b (isolate bk) [TaxId:11105] [188687] (17 PDB entries)

8. Domain d3h98b1: 3h98 B:2-563 [177330]
   Other proteins in same PDB: d3h98a2, d3h98b2
   automated match to d1nb4a_
   complexed with b5p, gol

Details for d3h98b1

PDB Entry: 3h98, 1.9 Å

PDB Description: Crystal structure of HCV NS5b 1b with (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyrimidine derivative

PDB Compounds: (B:) RNA-directed RNA polymerase

SCOPe Domain Sequences for d3h98b1:

Sequence, based on SEQRES records:

>d3h98b1 e.8.1.4 (B:2-563) automated matches {Hepatitis C virus genotype 1b (isolate bk) [TaxId: 11105]}
msytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvld
dhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhihs
vwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvst
lpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyq
ccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasa
acraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydle
litscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwa
rmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspge
inrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipa
asrldlsgwfvagysggdiyhs

Sequence, based on observed residues (ATOM records):

>d3h98b1 e.8.1.4 (B:2-563) automated matches {Hepatitis C virus genotype 1b (isolate bk) [TaxId: 11105]}
msytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvld
dhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhihs
vwkdlledtvtpidttimaknevfcvqgrkparlivfpdlgvrvcekmalydvvstlpqv
vmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccdl
apearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacra
aklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydlelits
cssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmil
mthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinrv
asclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipasrld
lsgwfvagysggdiyhs

Timeline for d3h98b1:

• d3h98b1 first appeared in SCOPe 2.01, called d3h98b_
  
• d3h98b1 appears in SCOPe 2.06
  
• d3h98b1 appears in the current release, SCOPe 2.08