PDB entry 3h98

View 3h98 on RCSB PDB site
Description: Crystal structure of HCV NS5b 1b with (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyrimidine derivative
Class: transferase
Keywords: RNA polymerase, nucleotide binding, TRANSFERASE
Deposited on 2009-04-30, released 2009-10-13
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.211
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus (isolate BK) [TaxId:11105]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P26663 (7-End)
      • expression tag (5-6)
    Domains in SCOPe 2.07: d3h98a1, d3h98a2
  • Chain 'B':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus (isolate BK) [TaxId:11105]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P26663 (7-End)
      • expression tag (5-6)
    Domains in SCOPe 2.07: d3h98b1, d3h98b2
  • Heterogens: B5P, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3h98A (A:)
mhhhhhhmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtf
drlqvlddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlssk
avnhihsvwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekma
lydvvstlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendir
veesiyqccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntlt
cylkasaacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdpp
qpeydlelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniim
yaptlwarmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafsl
hsyspgeinrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktkl
kltpipaasrldlsgwfvagysggdiyhslsrarpr

    Sequence, based on observed residues (ATOM records): (download) 
    >3h98A (A:)
hhmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqv
lddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhi
hsvwkdlledtvtpidttimaknevfcvqgrkparlivfpdlgvrvcekmalydvvstlp
qvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqcc
dlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaac
raaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydleli
tscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarm
ilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgein
rvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpisgwf
vagysggdiyh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3h98B (B:)
mhhhhhhmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtf
drlqvlddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlssk
avnhihsvwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekma
lydvvstlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendir
veesiyqccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntlt
cylkasaacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdpp
qpeydlelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniim
yaptlwarmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafsl
hsyspgeinrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktkl
kltpipaasrldlsgwfvagysggdiyhslsrarpr

    Sequence, based on observed residues (ATOM records): (download) 
    >3h98B (B:)
hhmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqv
lddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhi
hsvwkdlledtvtpidttimaknevfcvqgrkparlivfpdlgvrvcekmalydvvstlp
qvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqcc
dlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaac
raaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydleli
tscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarm
ilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgein
rvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipasr
ldlsgwfvagysggdiyhs