SCOPe 2.01: Domain d3gnva_: 3gnv A:

Lineage for d3gnva_ (3gnv A:)

1. Root: SCOPe 2.01

2. Class e: Multi-domain proteins (alpha and beta) [56572] (66 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (6 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein Viral RNA polymerase [56695] (14 species)

7. Species Hepatitis c virus isolate [TaxId:420174] [188905] (3 PDB entries)

8. Domain d3gnva_: 3gnv A: [176783]
   automated match to d1nb4a_
   protein/RNA complex; complexed with gol, xnz

Details for d3gnva_

PDB Entry: 3gnv, 2.75 Å

PDB Description: HCV NS5B polymerase in complex with 1,5 benzodiazepine inhibitor 1b

PDB Compounds: (A:) RNA-directed RNA polymerase

SCOPe Domain Sequences for d3gnva_:

Sequence; same for both SEQRES and ATOM records:

>d3gnva_ e.8.1.4 (A:) Viral RNA polymerase {Hepatitis c virus isolate [TaxId: 420174]}
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiy
qccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkat
aacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspg
einrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpip
aasqldlsgwfvagysggdiyhs

Timeline for d3gnva_:

• d3gnva_ is new in SCOPe 2.01-stable
  
• d3gnva_ appears in SCOPe 2.02
  
• d3gnva_ appears in the current release, SCOPe 2.08