SCOPe 2.05: Domain d3cj4a_: 3cj4 A:

Lineage for d3cj4a_ (3cj4 A:)

1. Root: SCOPe 2.05

2. Class e: Multi-domain proteins (alpha and beta) [56572] (68 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein Viral RNA polymerase [56695] (17 species)

7. Species Hepatitis C virus [TaxId:11103] [56697] (72 PDB entries)

8. Domain d3cj4a_: 3cj4 A: [173272]
   automated match to d1nb4a_
   protein/RNA complex; complexed with ni, sx5

Details for d3cj4a_

PDB Entry: 3cj4, 2.07 Å

PDB Description: Crystal structure of hepatitis c virus rna-dependent rna polymerase ns5b in complex with optimized small molecule fragments

PDB Compounds: (A:) RNA-directed RNA polymerase

SCOPe Domain Sequences for d3cj4a_:

Sequence, based on SEQRES records:

>d3cj4a_ e.8.1.4 (A:) Viral RNA polymerase {Hepatitis C virus [TaxId: 11103]}
hhmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqv
lddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhi
hsvwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvv
stlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesi
yqccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylka
saacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeyd
lelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptl
warmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsysp
geinrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpi
paasrldlsgwfvagysggdiyh

Sequence, based on observed residues (ATOM records):

>d3cj4a_ e.8.1.4 (A:) Viral RNA polymerase {Hepatitis C virus [TaxId: 11103]}
hhmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqv
lddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhi
hsvwkdlledtvtpidttimaknevfcvqrkparlivfpdlgvrvcekmalydvvstlpq
vvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccd
lapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacr
aaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydlelit
scssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmi
lmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinr
vasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipaasr
ldlsgwfvagysggdiyh

Timeline for d3cj4a_:

• d3cj4a_ first appeared in SCOPe 2.01
  
• d3cj4a_ appears in SCOPe 2.04
  
• d3cj4a_ is called d3cj4a1 in SCOPe 2.06
  
• d3cj4a_ appears in the current release, SCOPe 2.08, called d3cj4a1