SCOPe 2.06: Domain d2girb1: 2gir B:2-562

Lineage for d2girb1 (2gir B:2-562)

1. Root: SCOPe 2.06

2. Class e: Multi-domain proteins (alpha and beta) [56572] (69 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein Viral RNA polymerase [56695] (18 species)

7. Species Hepatitis C virus isolate bk [TaxId:11105] [195056] (4 PDB entries)

8. Domain d2girb1: 2gir B:2-562 [164727]
   Other proteins in same PDB: d2gira2, d2girb2
   automated match to d1nb4a_
   complexed with nn3

Details for d2girb1

PDB Entry: 2gir, 1.9 Å

PDB Description: hepatitis c virus rna-dependent rna polymerase ns5b with nni-1 inhibitor

PDB Compounds: (B:) RNA-directed RNA polymerase

SCOPe Domain Sequences for d2girb1:

Sequence, based on SEQRES records:

>d2girb1 e.8.1.4 (B:2-562) Viral RNA polymerase {Hepatitis C virus isolate bk [TaxId: 11105]}
msytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvld
dhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhihs
vwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvst
lpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyq
ccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasa
acraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydle
litscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwa
rmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspge
inrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipa
asrldlsgwfvagysggdiyh

Sequence, based on observed residues (ATOM records):

>d2girb1 e.8.1.4 (B:2-562) Viral RNA polymerase {Hepatitis C virus isolate bk [TaxId: 11105]}
msytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvld
dhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhihs
vwkdlledtvtpidttimaknevfcvqrkparlivfpdlgvrvcekmalydvvstlpqvv
mgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccdla
pearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacraa
klqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydlelitsc
ssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmilm
thffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinrva
sclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipaasrld
lsgwfvagysggdiyh

Timeline for d2girb1:

• d2girb1 first appeared in SCOPe 2.01, called d2girb_
  
• d2girb1 was called d2girb_ in SCOPe 2.05
  
• d2girb1 appears in SCOPe 2.07
  
• d2girb1 appears in the current release, SCOPe 2.08