SCOPe 2.08: Domain d3b2rb_: 3b2r B:

Lineage for d3b2rb_ (3b2r B:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (9 families)

5. Family a.211.1.2: PDEase [48548] (7 proteins)
   Pfam PF00233; multihelical; can be divided into three subdomains

6. Protein cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx [101439] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [101440] (26 PDB entries)
   Uniprot O76074 534-860

8. Domain d3b2rb_: 3b2r B: [154769]
   Other proteins in same PDB: d3b2ra3
   automated match to d1rkpa_
   complexed with vdn

Details for d3b2rb_

PDB Entry: 3b2r, 2.07 Å

PDB Description: Crystal Structure of PDE5A1 catalytic domain in complex with Vardenafil

PDB Compounds: (B:) cGMP-specific 3',5'-cyclic phosphodiesterase

SCOPe Domain Sequences for d3b2rb_:

Sequence, based on SEQRES records:

>d3b2rb_ a.211.1.2 (B:) cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx {Human (Homo sapiens) [TaxId: 9606]}
relqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhevlcr
wilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshdldh
rgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeykttlkiik
qailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpiqqr
iaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealthvse
dcfplldgcrknrqkwqalaeqq

Sequence, based on observed residues (ATOM records):

>d3b2rb_ a.211.1.2 (B:) cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx {Human (Homo sapiens) [TaxId: 9606]}
relqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhevlcr
wilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshdldh
rgchsimehhhfdqclmilnspgnqilsglsieeykttlkiikqailatdlalyikrrge
ffelirknqfnledphqkelflamlmtacdlsaitkpwpiqqriaelvateffdqkknki
psmqvgfidaiclqlyealthvsedcfplldgcrknrqkwqalaeqq

Timeline for d3b2rb_:

• d3b2rb_ first appeared in SCOP 1.75, called d3b2rb1
  
• d3b2rb_ appears in SCOPe 2.07