SCOPe 2.01: Domain d2p40a1: 2p40 A:8-264

Lineage for d2p40a1 (2p40 A:8-264)

1. Root: SCOPe 2.01

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest

4. Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (58 families)

5. Family c.66.1.25: mRNA cap methylase [88785] (3 proteins)

6. Protein An RNA cap (nucleoside-2'-O-)-methyltransferase domain of RNA polymerase NS5 [89741] (3 species)
   structurally and functionally similar to VP39

7. Species Dengue virus 2 [TaxId:11060] [159679] (5 PDB entries)

8. Domain d2p40a1: 2p40 A:8-264 [149192]
   automatically matched to d1l9ka_
   complexed with gtg, so4

Details for d2p40a1

PDB Entry: 2p40, 2.7 Å

PDB Description: Crystal Structure of Dengue Methyltransferase in Complex with 7MeGpppG

PDB Compounds: (A:) type II methyltransferase

SCOPe Domain Sequences for d2p40a1:

Sequence; same for both SEQRES and ATOM records:

>d2p40a1 c.66.1.25 (A:8-264) An RNA cap (nucleoside-2'-O-)-methyltransferase domain of RNA polymerase NS5 {Dengue virus 2 [TaxId: 11060]}
tlgekwksrlnalgksefqiykksgiqevdrtlakegikrgetdhhavsrgsaklrwfve
rnlvtpegkvvdlgcgrggwsyycgglknvrevkgltkggpgheepipmstygwnlvrlq
sgvdvffippercdtllcdigesspnptveagrtlrvlnlvenwlsnntqfcvkvlnpym
ssviekmealqrkhggalvrnplsrnsthemywvsnasgnivssvnmisrmlinrftmrh
kkatyepdvdlgsgtrn

Timeline for d2p40a1:

• d2p40a1 first appeared in SCOP 1.75
  
• d2p40a1 appears in SCOPe 2.02
  
• d2p40a1 appears in the current release, SCOPe 2.08, called d2p40a_