SCOPe 2.01: Family c.66.1.25: mRNA cap methylase

Lineage for Family c.66.1.25: mRNA cap methylase

1. Root: SCOPe 2.01

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest

4. Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (58 families)

5. Family c.66.1.25: mRNA cap methylase [88785] (3 proteins)

Proteins:

1. An RNA cap (nucleoside-2'-O-)-methyltransferase domain of RNA polymerase NS5 [89741] (3 species)
   structurally and functionally similar to VP39

   1. Species Dengue virus 2 [TaxId:11060] [159679] (5 PDB entries)

   2. Species Flavivirus (Dengue virus type 2) [TaxId:12637] [89742] (3 PDB entries)
      Uniprot P12823 2495-2756

   3. Species Murray valley encephalitis virus (strain mve-1-51) [TaxId:301478] [187362] (6 PDB entries)

2. Polymerase regulatory subunit VP39 [53361] (1 species)

   • Species Vaccinia virus [TaxId:10245] [53362] (18 PDB entries)

3. automated matches [190302] (5 species)
   not a true protein

   1. Species Dengue virus 2 16681-pdk53 [TaxId:31635] [188733] (1 PDB entry)

   2. Species Dengue virus 3 [TaxId:11069] [189561] (2 PDB entries)

   3. Species Dengue virus [TaxId:12637] [189508] (1 PDB entry)

   4. Species Vaccinia virus [TaxId:10245] [187111] (2 PDB entries)

   5. Species West Nile virus [TaxId:11082] [187969] (1 PDB entry)

More info for Family c.66.1.25: mRNA cap methylase

Timeline for Family c.66.1.25: mRNA cap methylase:

• Family c.66.1.25: mRNA cap methylase first appeared in SCOP 1.65
  
• Family c.66.1.25: mRNA cap methylase appears in SCOP 1.75
  
• Family c.66.1.25: mRNA cap methylase appears in SCOPe 2.02
  
• Family c.66.1.25: mRNA cap methylase appears in the current release, SCOPe 2.08