SCOP 1.75: Species: Human (Homo sapiens) [TaxId: 9606]

Lineage for Species: Human (Homo sapiens) [TaxId: 9606]

Root: SCOP 1.75
Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins)
also known as short-chain dehydrogenases and SDR family
parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)
Species Human (Homo sapiens) [TaxId:9606] [117424] (11 PDB entries)
Uniprot P28845

PDB entries in Species: Human (Homo sapiens) [TaxId: 9606]:

Domain(s) for 1xu7:
1. Domain d1xu7a_: 1xu7 A: [116048]
2. Domain d1xu7b_: 1xu7 B: [116049]
3. Domain d1xu7c_: 1xu7 C: [116050]
4. Domain d1xu7d_: 1xu7 D: [116051]
  complexed with cps, ndp; mutant
Domain(s) for 1xu9:
1. Domain d1xu9a_: 1xu9 A: [116052]
2. Domain d1xu9b_: 1xu9 B: [116053]
3. Domain d1xu9c_: 1xu9 C: [116054]
4. Domain d1xu9d_: 1xu9 D: [116055]
  complexed with cps, mes, ndp; mutant
Domain(s) for 2bel:
1. Domain d2bela_: 2bel A: [116694]
2. Domain d2belb_: 2bel B: [116695]
3. Domain d2belc_: 2bel C: [116696]
4. Domain d2beld_: 2bel D: [116697]
  complexed with cbo, cl, nap
Domain(s) for 2irw:
1. Domain d2irwa1: 2irw A:26-289 [137593]
  automatically matched to d1xu9b_
  complexed with nap, nn4
2. Domain d2irwb1: 2irw B:26-289 [137594]
  automatically matched to d1xu9b_
  complexed with nap, nn4
3. Domain d2irwc1: 2irw C:26-282 [137595]
  automatically matched to d1xu9b_
  complexed with nap, nn4
4. Domain d2irwd1: 2irw D:26-289 [137596]
  automatically matched to d1xu9b_
  complexed with nap, nn4
5. Domain d2irwe1: 2irw E:26-282 [137597]
  automatically matched to d1xu9b_
  complexed with nap, nn4
6. Domain d2irwf1: 2irw F:26-289 [137598]
  automatically matched to d1xu9b_
  complexed with nap, nn4
7. Domain d2irwg1: 2irw G:26-289 [137599]
  automatically matched to d1xu9b_
  complexed with nap, nn4
8. Domain d2irwh1: 2irw H:26-289 [137600]
  automatically matched to d1xu9b_
  complexed with nap, nn4
Domain(s) for 2rbe:
1. Domain d2rbea1: 2rbe A:25-284 [151846]
  automatically matched to d1xu9b_
  complexed with ndp, zmg; mutant
2. Domain d2rbeb1: 2rbe B:27-281 [151847]
  automatically matched to d1xu9b_
  complexed with ndp, zmg; mutant
3. Domain d2rbec1: 2rbe C:26-280 [151848]
  automatically matched to d1xu9b_
  complexed with ndp, zmg; mutant
4. Domain d2rbed1: 2rbe D:25-284 [151849]
  automatically matched to d1xu9b_
  complexed with ndp, zmg; mutant
Domain(s) for 3byz:
1. Domain d3byza1: 3byz A:25-282 [155734]
  automatically matched to d1xu9b_
  complexed with h11, ndp; mutant
2. Domain d3byzb1: 3byz B:27-281 [155735]
  automatically matched to d1xu9b_
  complexed with h11, ndp; mutant
3. Domain d3byzc1: 3byz C:26-280 [155736]
  automatically matched to d1xu9b_
  complexed with h11, ndp; mutant
4. Domain d3byzd1: 3byz D:25-284 [155737]
  automatically matched to d1xu9b_
  complexed with h11, ndp; mutant
Domain(s) for 3bzu:
1. Domain d3bzua1: 3bzu A:25-287 [155788]
  automatically matched to d1xu9b_
  complexed with a21, nap; mutant
2. Domain d3bzub1: 3bzu B:25-283 [155789]
  automatically matched to d1xu9b_
  complexed with a21, nap; mutant
3. Domain d3bzuc1: 3bzu C:25-282 [155790]
  automatically matched to d1xu9b_
  complexed with a21, nap; mutant
4. Domain d3bzud1: 3bzu D:26-281 [155791]
  automatically matched to d1xu9b_
  complexed with a21, nap; mutant
Domain(s) for 3czr:
1. Domain d3czra1: 3czr A:25-285 [157154]
  automatically matched to d1xu9b_
  complexed with 3cz, cps, nap; mutant
2. Domain d3czrb1: 3czr B:25-283 [157155]
  automatically matched to d1xu9b_
  complexed with 3cz, cps, nap; mutant
Domain(s) for 3d3e:
1. Domain d3d3ea1: 3d3e A:25-284 [157280]
  automatically matched to d1xu9b_
  complexed with d3e, nap; mutant
2. Domain d3d3eb1: 3d3e B:25-281 [157281]
  automatically matched to d1xu9b_
  complexed with d3e, nap; mutant
3. Domain d3d3ec1: 3d3e C:25-281 [157282]
  automatically matched to d1xu9b_
  complexed with d3e, nap; mutant
4. Domain d3d3ed1: 3d3e D:25-281 [157283]
  automatically matched to d1xu9b_
  complexed with d3e, nap; mutant
Domain(s) for 3d4n:
1. Domain d3d4na1: 3d4n A:25-282 [157296]
  automatically matched to d1xu9b_
  complexed with d4n, nap; mutant
2. Domain d3d4nb1: 3d4n B:25-284 [157297]
  automatically matched to d1xu9b_
  complexed with d4n, nap; mutant
3. Domain d3d4nc1: 3d4n C:25-281 [157298]
  automatically matched to d1xu9b_
  complexed with d4n, nap; mutant
4. Domain d3d4nd1: 3d4n D:25-281 [157299]
  automatically matched to d1xu9b_
  complexed with d4n, nap; mutant
Domain(s) for 3d5q:
1. Domain d3d5qa1: 3d5q A:25-287 [157399]
  automatically matched to d1xu9b_
  complexed with nap, t30; mutant
2. Domain d3d5qb1: 3d5q B:25-284 [157400]
  automatically matched to d1xu9b_
  complexed with nap, t30; mutant
3. Domain d3d5qc1: 3d5q C:25-281 [157401]
  automatically matched to d1xu9b_
  complexed with nap, t30; mutant
4. Domain d3d5qd1: 3d5q D:25-281 [157402]
  automatically matched to d1xu9b_
  complexed with nap, t30; mutant

More info for Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 11-beta-hydroxysteroid dehydrogenase 1

Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 11-beta-hydroxysteroid dehydrogenase 1:

Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 11-beta-hydroxysteroid dehydrogenase 1 first appeared in SCOP 1.71
Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 11-beta-hydroxysteroid dehydrogenase 1 appears in SCOP 1.73
Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 11-beta-hydroxysteroid dehydrogenase 1 appears in SCOPe 2.01
Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 11-beta-hydroxysteroid dehydrogenase 1 appears in the current release, SCOPe 2.08