Lineage for Protein: 11-beta-hydroxysteroid dehydrogenase 1

  1. Root: SCOP 1.75
  2. 814173Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 819418Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 819419Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families) (S)
  5. 819736Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 819766Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)

Species:

  1. 819767Guinea pig (Cavia porcellus) [TaxId:10141] [117425] (1 PDB entry)
    Uniprot Q6QLL4 23-296
  2. 819770Human (Homo sapiens) [TaxId:9606] [117424] (11 PDB entries)
    Uniprot P28845
    1. Domains for 1xu7:
      1. 819775Domain d1xu7a_: 1xu7 A: [116048]
      2. 819776Domain d1xu7b_: 1xu7 B: [116049]
      3. 819777Domain d1xu7c_: 1xu7 C: [116050]
      4. 819778Domain d1xu7d_: 1xu7 D: [116051]
        complexed with cps, ndp; mutant
    2. Domains for 1xu9:
      1. 819771Domain d1xu9a_: 1xu9 A: [116052]
      2. 819772Domain d1xu9b_: 1xu9 B: [116053]
      3. 819773Domain d1xu9c_: 1xu9 C: [116054]
      4. 819774Domain d1xu9d_: 1xu9 D: [116055]
        complexed with cps, mes, ndp; mutant
    3. Domains for 2bel:
      1. 819783Domain d2bela_: 2bel A: [116694]
      2. 819784Domain d2belb_: 2bel B: [116695]
      3. 819785Domain d2belc_: 2bel C: [116696]
      4. 819786Domain d2beld_: 2bel D: [116697]
        complexed with cbo, cl, nap
    4. Domains for 2irw:
      1. 819809Domain d2irwa1: 2irw A:26-289 [137593]
        automatically matched to d1xu9b_
        complexed with nap, nn4
      2. 819810Domain d2irwb1: 2irw B:26-289 [137594]
        automatically matched to d1xu9b_
        complexed with nap, nn4
      3. 819811Domain d2irwc1: 2irw C:26-282 [137595]
        automatically matched to d1xu9b_
        complexed with nap, nn4
      4. 819812Domain d2irwd1: 2irw D:26-289 [137596]
        automatically matched to d1xu9b_
        complexed with nap, nn4
      5. 819813Domain d2irwe1: 2irw E:26-282 [137597]
        automatically matched to d1xu9b_
        complexed with nap, nn4
      6. 819814Domain d2irwf1: 2irw F:26-289 [137598]
        automatically matched to d1xu9b_
        complexed with nap, nn4
      7. 819815Domain d2irwg1: 2irw G:26-289 [137599]
        automatically matched to d1xu9b_
        complexed with nap, nn4
      8. 819816Domain d2irwh1: 2irw H:26-289 [137600]
        automatically matched to d1xu9b_
        complexed with nap, nn4
    5. Domains for 2rbe:
      1. 819779Domain d2rbea1: 2rbe A:25-284 [151846]
        automatically matched to d1xu9b_
        complexed with ndp, zmg; mutant
      2. 819780Domain d2rbeb1: 2rbe B:27-281 [151847]
        automatically matched to d1xu9b_
        complexed with ndp, zmg; mutant
      3. 819781Domain d2rbec1: 2rbe C:26-280 [151848]
        automatically matched to d1xu9b_
        complexed with ndp, zmg; mutant
      4. 819782Domain d2rbed1: 2rbe D:25-284 [151849]
        automatically matched to d1xu9b_
        complexed with ndp, zmg; mutant
    6. Domains for 3byz:
      1. 819805Domain d3byza1: 3byz A:25-282 [155734]
        automatically matched to d1xu9b_
        complexed with h11, ndp; mutant
      2. 819806Domain d3byzb1: 3byz B:27-281 [155735]
        automatically matched to d1xu9b_
        complexed with h11, ndp; mutant
      3. 819807Domain d3byzc1: 3byz C:26-280 [155736]
        automatically matched to d1xu9b_
        complexed with h11, ndp; mutant
      4. 819808Domain d3byzd1: 3byz D:25-284 [155737]
        automatically matched to d1xu9b_
        complexed with h11, ndp; mutant
    7. Domains for 3bzu:
      1. 819787Domain d3bzua1: 3bzu A:25-287 [155788]
        automatically matched to d1xu9b_
        complexed with a21, nap; mutant
      2. 819788Domain d3bzub1: 3bzu B:25-283 [155789]
        automatically matched to d1xu9b_
        complexed with a21, nap; mutant
      3. 819789Domain d3bzuc1: 3bzu C:25-282 [155790]
        automatically matched to d1xu9b_
        complexed with a21, nap; mutant
      4. 819790Domain d3bzud1: 3bzu D:26-281 [155791]
        automatically matched to d1xu9b_
        complexed with a21, nap; mutant
    8. Domains for 3czr:
      1. 819791Domain d3czra1: 3czr A:25-285 [157154]
        automatically matched to d1xu9b_
        complexed with 3cz, cps, nap; mutant
      2. 819792Domain d3czrb1: 3czr B:25-283 [157155]
        automatically matched to d1xu9b_
        complexed with 3cz, cps, nap; mutant
    9. Domains for 3d3e:
      1. 819797Domain d3d3ea1: 3d3e A:25-284 [157280]
        automatically matched to d1xu9b_
        complexed with d3e, nap; mutant
      2. 819798Domain d3d3eb1: 3d3e B:25-281 [157281]
        automatically matched to d1xu9b_
        complexed with d3e, nap; mutant
      3. 819799Domain d3d3ec1: 3d3e C:25-281 [157282]
        automatically matched to d1xu9b_
        complexed with d3e, nap; mutant
      4. 819800Domain d3d3ed1: 3d3e D:25-281 [157283]
        automatically matched to d1xu9b_
        complexed with d3e, nap; mutant
    10. Domains for 3d4n:
      1. 819793Domain d3d4na1: 3d4n A:25-282 [157296]
        automatically matched to d1xu9b_
        complexed with d4n, nap; mutant
      2. 819794Domain d3d4nb1: 3d4n B:25-284 [157297]
        automatically matched to d1xu9b_
        complexed with d4n, nap; mutant
      3. 819795Domain d3d4nc1: 3d4n C:25-281 [157298]
        automatically matched to d1xu9b_
        complexed with d4n, nap; mutant
      4. 819796Domain d3d4nd1: 3d4n D:25-281 [157299]
        automatically matched to d1xu9b_
        complexed with d4n, nap; mutant
    11. Domains for 3d5q:
      1. 819801Domain d3d5qa1: 3d5q A:25-287 [157399]
        automatically matched to d1xu9b_
        complexed with nap, t30; mutant
      2. 819802Domain d3d5qb1: 3d5q B:25-284 [157400]
        automatically matched to d1xu9b_
        complexed with nap, t30; mutant
      3. 819803Domain d3d5qc1: 3d5q C:25-281 [157401]
        automatically matched to d1xu9b_
        complexed with nap, t30; mutant
      4. 819804Domain d3d5qd1: 3d5q D:25-281 [157402]
        automatically matched to d1xu9b_
        complexed with nap, t30; mutant
  3. 819817Mouse (Mus musculus) [TaxId:10090] [141879] (2 PDB entries)
    Uniprot P50172 24-298
    1. Domains for 1y5m:
      1. 819818Domain d1y5ma1: 1y5m A:25-289 [122645]
        complexed with ndp, oct, so4
      2. 819819Domain d1y5mb1: 1y5m B:25-289 [122646]
        automatically matched to 1Y5M A:25-289
        complexed with ndp, oct, so4
    2. Domains for 1y5r:
      1. 819820Domain d1y5ra1: 1y5r A:25-289 [122651]
        automatically matched to 1Y5M A:25-289
        complexed with c0r, ndp
      2. 819821Domain d1y5rb1: 1y5r B:25-289 [122652]
        automatically matched to 1Y5M A:25-289
        complexed with c0r, ndp

More info for Protein 11-beta-hydroxysteroid dehydrogenase 1 from c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Protein 11-beta-hydroxysteroid dehydrogenase 1 from c.2.1.2: Tyrosine-dependent oxidoreductases: