SCOP 1.75: Domain d3d5qa1: 3d5q A:25-287

Lineage for d3d5qa1 (3d5q A:25-287)

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [117424] (11 PDB entries)
   Uniprot P28845

8. Domain d3d5qa1: 3d5q A:25-287 [157399]
   automatically matched to d1xu9b_
   complexed with nap, t30; mutant

Details for d3d5qa1

PDB Entry: 3d5q, 2.55 Å

PDB Description: crystal structure of 11b-hsd1 in complex with triazole inhibitor

PDB Compounds: (A:) Corticosteroid 11-beta-dehydrogenase isozyme 1

SCOP Domain Sequences for d3d5qa1:

Sequence, based on SEQRES records:

>d3d5qa1 c.2.1.2 (A:25-287) 11-beta-hydroxysteroid dehydrogenase 1 {Human (Homo sapiens) [TaxId: 9606]}
eefrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelgaa
sahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnf
lsyvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirkeysvs
rvnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyydsslwt
tllirnpsrkileflystsynmd

Sequence, based on observed residues (ATOM records):

>d3d5qa1 c.2.1.2 (A:25-287) 11-beta-hydroxysteroid dehydrogenase 1 {Human (Homo sapiens) [TaxId: 9606]}
eefrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelgaa
sahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnf
lsyvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirkeysvs
rvnvsitlcvlglidtetamkavmqaapkeecaleiikggalrqeevyydsslwttllir
npsrkileflystsynmd

Timeline for d3d5qa1:

• d3d5qa1 is new in SCOP 1.75
  
• d3d5qa1 is called d3d5qa_ in SCOPe 2.01
  
• d3d5qa1 appears in the current release, SCOPe 2.08, called d3d5qa2