PDB entry 7m7w

View 7m7w on RCSB PDB site
Description: Antibodies to the SARS-CoV-2 receptor-binding domain that maximize breadth and resistance to viral escape
Class: viral protein/immune system
Keywords: COVID-19, SARS-CoV-2, neutralizing monoclonal antibody, VIRAL PROTEIN-IMMUNE SYSTEM complex
Deposited on 2021-03-29, released 2021-05-05
The last revision prior to the SCOPe 2.07 freeze date was dated 2021-05-05, with a file datestamp of 2021-04-30.
Experiment type: XRAY
Resolution: 2.65 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Monoclonal antibody S2X259 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7M7W
  • Chain 'B':
    Compound: Monoclonal antibody S2X259 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7M7W
    Domains in SCOPe 2.07: d7m7wb1, d7m7wb2
  • Chain 'C':
    Compound: Monoclonal antibody S2H97 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7M7W (0-End)
  • Chain 'D':
    Compound: Monoclonal antibody S2H97 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7M7W
    Domains in SCOPe 2.07: d7m7wd1, d7m7wd2
  • Chain 'E':
    Compound: Monoclonal antibody S2H97 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7M7W (0-End)
  • Chain 'F':
    Compound: Monoclonal antibody S2H97 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7M7W
    Domains in SCOPe 2.07: d7m7wf1, d7m7wf2
  • Chain 'H':
    Compound: Monoclonal antibody S2X259 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7M7W
  • Chain 'L':
    Compound: Monoclonal antibody S2X259 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7M7W
    Domains in SCOPe 2.07: d7m7wl1, d7m7wl2
  • Chain 'R':
    Compound: Spike protein S1
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d7m7wr_
  • Chain 'S':
    Compound: Spike protein S1
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d7m7ws_
  • Heterogens: NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7m7wB (B:)
qtvltqppsvsgapgqrvtisctgsnsnigagydvhwyqqlpgtapkllicgnsnrpsgv
pdrfsgsksgtsaslaitglqaedeadyycqsydsslsgpnwvfgggtkltvlgqpkaap
svtlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkya
assylsltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records): (download) 
    >7m7wB (B:)
tvltqppsvsgapgqrvtisctgsnsnigagydvhwyqqlpgtapkllicgnsnrpsgvp
drfsgsksgtsaslaitglqaedeadyycqsydsslsgpnwvfgggtkltvlgqpkaaps
vtlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaa
ssylsltpeqwkshrsyscqvthegstvektvapte

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7m7wD (D:)
qsvltqpasvsgspgqsitisctgissdvggynsvswyqqhpgkapklmiydvtnrpsgv
snrfsgsksgntasltisglqaedeadyycssytssstppyvfgtgtkvsvlgqpkaaps
vtlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaa
ssylsltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records): (download) 
    >7m7wD (D:)
svltqpasvsgspgqsitisctgissdvggynsvswyqqhpgkapklmiydvtnrpsgvs
nrfsgsksgntasltisglqaedeadyycssytssstppyvfgtgtkvsvlgqpkaapsv
tlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaas
sylsltpeqwkshrsyscqvthegstvektvapte

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >7m7wF (F:)
qsvltqpasvsgspgqsitisctgissdvggynsvswyqqhpgkapklmiydvtnrpsgv
snrfsgsksgntasltisglqaedeadyycssytssstppyvfgtgtkvsvlgqpkaaps
vtlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaa
ssylsltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records): (download) 
    >7m7wF (F:)
svltqpasvsgspgqsitisctgissdvggynsvswyqqhpgkapklmiydvtnrpsgvs
nrfsgsksgntasltisglqaedeadyycssytssstppyvfgtgtkvsvlgqpkaapsv
tlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaas
sylsltpeqwkshrsyscqvthegstvektvapte

  • Chain 'H':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >7m7wL (L:)
qtvltqppsvsgapgqrvtisctgsnsnigagydvhwyqqlpgtapkllicgnsnrpsgv
pdrfsgsksgtsaslaitglqaedeadyycqsydsslsgpnwvfgggtkltvlgqpkaap
svtlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkya
assylsltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records): (download) 
    >7m7wL (L:)
tvltqppsvsgapgqrvtisctgsnsnigagydvhwyqqlpgtapkllicgnsnrpsgvp
drfsgsksgtsaslaitglqaedeadyycqsydsslsgpnwvfgggtkltvlgqpkaaps
vtlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaa
ssylsltpeqwkshrsyscqvthegstvektvapte

  • Chain 'R':
    Sequence, based on SEQRES records: (download) 
    >7m7wR (R:)
etgtrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvs
ptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnlds
kvggnynylyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngv
gyqpyrvvvlsfellhapatvcgpkksthhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7m7wR (R:)
itnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlc
ftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskvggnyny
lyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngvgyqpyrvv
vlsfellhapatvcgpkk

  • Chain 'S':
    Sequence, based on SEQRES records: (download) 
    >7m7wS (S:)
etgtrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvs
ptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnlds
kvggnynylyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngv
gyqpyrvvvlsfellhapatvcgpkksthhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7m7wS (S:)
itnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlc
ftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskvggnyny
lyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngvgyqpyrvv
vlsfellhapatvcgpk