PDB entry 7edz

View 7edz on RCSB PDB site
Description: Crystal Structure of human PPCS in complex with P-HoPan and AMPPNP
Class: ligase
Keywords: Phosphopantothenoylcysteine synthetase, LIGASE
Deposited on 2021-03-17, released 2021-11-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-11-24, with a file datestamp of 2021-11-19.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Phosphopantothenate--cysteine ligase
    Species: Homo sapiens [TaxId:9606]
    Gene: PPCS, COAB
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9HAB8 (0-310)
      • variant (145)
      • variant (267)
    Domains in SCOPe 2.08: d7edza_
  • Chain 'B':
    Compound: Phosphopantothenate--cysteine ligase
    Species: Homo sapiens [TaxId:9606]
    Gene: PPCS, COAB
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9HAB8 (0-310)
      • variant (145)
      • variant (267)
    Domains in SCOPe 2.08: d7edzb_
  • Chain 'C':
    Compound: Phosphopantothenate--cysteine ligase
    Species: Homo sapiens [TaxId:9606]
    Gene: PPCS, COAB
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9HAB8 (0-310)
      • variant (145)
      • variant (267)
    Domains in SCOPe 2.08: d7edzc_
  • Chain 'D':
    Compound: Phosphopantothenate--cysteine ligase
    Species: Homo sapiens [TaxId:9606]
    Gene: PPCS, COAB
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9HAB8 (0-310)
      • variant (145)
      • variant (267)
    Domains in SCOPe 2.08: d7edzd_
  • Heterogens: ANP, SO4, MG, J1O, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7edzA (A:)
maemdpvaefpqppgaarwaevmarfaarlgaqgrrvvlvtsggtkvplearpvrfldnf
ssgrrgatsaeaflaagygvlflyrarsafpyahrfppqtwlsalrpsgpalsgllslea
eenalpgfaealrsyqeaaaagtflvvefttladylhllqaaaqalnplgpsamfylaaa
vsdfyvpvsempehkiqssggplqitmkmvpkllsplvkdwapkafiisfkletdpaivi
nrarkaleiyqhqvvvanilesrqsfvlivtkdsetklllseeeiekgveieekivdnlq
srhtafigdrn

    Sequence, based on observed residues (ATOM records): (download) 
    >7edzA (A:)
dpvaefpqppgaarwaevmarfaarlgaqgrrvvlvtsggtkvplearpvrfldnfssgr
rgatsaeaflaagygvlflyrarsafpyahrfppqtwlsalrpsgpalsgllsleaeena
lpgfaealrsyqeaaaagtflvvefttladylhllqaaaqalnplgpsamfylaaavsdf
yvpvsempehkiqssggplqitmkmvpkllsplvkdwapkafiisfkletdpaivinrar
kaleiyqhqvvvanilesrqsfvlivtkdsetklllseeeiekgveieekivdnlqsrht
afigd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7edzB (B:)
maemdpvaefpqppgaarwaevmarfaarlgaqgrrvvlvtsggtkvplearpvrfldnf
ssgrrgatsaeaflaagygvlflyrarsafpyahrfppqtwlsalrpsgpalsgllslea
eenalpgfaealrsyqeaaaagtflvvefttladylhllqaaaqalnplgpsamfylaaa
vsdfyvpvsempehkiqssggplqitmkmvpkllsplvkdwapkafiisfkletdpaivi
nrarkaleiyqhqvvvanilesrqsfvlivtkdsetklllseeeiekgveieekivdnlq
srhtafigdrn

    Sequence, based on observed residues (ATOM records): (download) 
    >7edzB (B:)
dpvaefpqppgaarwaevmarfaarlgaqgrrvvlvtsggtkvplearpvrfldnfssgr
rgatsaeaflaagygvlflyrarsafpyahrfppqtwlsalrpsgpalsgllsleaeena
lpgfaealrsyqeaaaagtflvvefttladylhllqaaaqalnplgpsamfylaaavsdf
yvpvsempehkiqssggplqitmkmvpkllsplvkdwapkafiisfkletdpaivinrar
kaleiyqhqvvvanilesrqsfvlivtkdsetklllseeeiekgveieekivdnlqsrht
afigdr

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7edzC (C:)
maemdpvaefpqppgaarwaevmarfaarlgaqgrrvvlvtsggtkvplearpvrfldnf
ssgrrgatsaeaflaagygvlflyrarsafpyahrfppqtwlsalrpsgpalsgllslea
eenalpgfaealrsyqeaaaagtflvvefttladylhllqaaaqalnplgpsamfylaaa
vsdfyvpvsempehkiqssggplqitmkmvpkllsplvkdwapkafiisfkletdpaivi
nrarkaleiyqhqvvvanilesrqsfvlivtkdsetklllseeeiekgveieekivdnlq
srhtafigdrn

    Sequence, based on observed residues (ATOM records): (download) 
    >7edzC (C:)
dpvaefpqppgaarwaevmarfaarlgaqgrrvvlvtsggtkvplearpvrfldnfssgr
rgatsaeaflaagygvlflyrarsafpyahrfppqtwlsalrpsgpalsgllsleaeena
lpgfaealrsyqeaaaagtflvvefttladylhllqaaaqalnplgpsamfylaaavsdf
yvpvsempehkiqssggplqitmkmvpkllsplvkdwapkafiisfkletdpaivinrar
kaleiyqhqvvvanilesrqsfvlivtkdsetklllseeeiekgveieekivdnlqsrht
afig

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7edzD (D:)
maemdpvaefpqppgaarwaevmarfaarlgaqgrrvvlvtsggtkvplearpvrfldnf
ssgrrgatsaeaflaagygvlflyrarsafpyahrfppqtwlsalrpsgpalsgllslea
eenalpgfaealrsyqeaaaagtflvvefttladylhllqaaaqalnplgpsamfylaaa
vsdfyvpvsempehkiqssggplqitmkmvpkllsplvkdwapkafiisfkletdpaivi
nrarkaleiyqhqvvvanilesrqsfvlivtkdsetklllseeeiekgveieekivdnlq
srhtafigdrn

    Sequence, based on observed residues (ATOM records): (download) 
    >7edzD (D:)
dpvaefpqppgaarwaevmarfaarlgaqgrrvvlvtsggtkvplearpvrfldnfssgr
rgatsaeaflaagygvlflyrarsafpyahrfppqtwlsalrpsgpalsgllsleaeena
lpgfaealrsyqeaaaagtflvvefttladylhllqaaaqalnplgpsamfylaaavsdf
yvpvsempehkiqssggplqitmkmvpkllsplvkdwapkafiisfkletdpaivinrar
kaleiyqhqvvvanilesrqsfvlivtkdsetklllseeeiekgveieekivdnlqsrht
afigd