PDB entry 7dbk

View 7dbk on RCSB PDB site
Description: Crystal structure of human LDHB in complex with NADH
Class: oxidoreductase
Keywords: Lactate dehydrogenase, Inhibitor, Complex, OXIDOREDUCTASE
Deposited on 2020-10-20, released 2021-10-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-11-10, with a file datestamp of 2021-11-05.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: L-lactate dehydrogenase B chain
    Species: Homo sapiens [TaxId:9606]
    Gene: LDHB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7dbka1, d7dbka2
  • Chain 'B':
    Compound: L-lactate dehydrogenase B chain
    Species: Homo sapiens [TaxId:9606]
    Gene: LDHB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7dbkb1, d7dbkb2
  • Chain 'C':
    Compound: L-lactate dehydrogenase B chain
    Species: Homo sapiens [TaxId:9606]
    Gene: LDHB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7dbkc1, d7dbkc2
  • Chain 'D':
    Compound: L-lactate dehydrogenase B chain
    Species: Homo sapiens [TaxId:9606]
    Gene: LDHB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7dbkd1, d7dbkd2
  • Chain 'E':
    Compound: L-lactate dehydrogenase B chain
    Species: Homo sapiens [TaxId:9606]
    Gene: LDHB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7dbke1, d7dbke2
  • Chain 'F':
    Compound: L-lactate dehydrogenase B chain
    Species: Homo sapiens [TaxId:9606]
    Gene: LDHB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7dbkf1, d7dbkf2
  • Chain 'G':
    Compound: L-lactate dehydrogenase B chain
    Species: Homo sapiens [TaxId:9606]
    Gene: LDHB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7dbkg1, d7dbkg2
  • Chain 'H':
    Compound: L-lactate dehydrogenase B chain
    Species: Homo sapiens [TaxId:9606]
    Gene: LDHB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7dbkh1, d7dbkh2
  • Heterogens: NAI, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7dbkA (A:)
atlkekliapvaeeeatvpnnkitvvgvgqvgmacaisilgksladelalvdvledklkg
emmdlqhgslflqtpkivadkdysvtanskivvvtagvrqqegesrlnlvqrnvnvfkfi
ipqivkyspdciiivvsnpvdiltyvtwklsglpkhrvigsgcnldsarfrylmaeklgi
hpsschgwilgehgdssvavwsgvnvagvslqelnpemgtdndsenwkevhkmvvesaye
viklkgytnwaiglsvadliesmlknlsrihpvstmvkgmygienevflslpcilnargl
tsvinqklkddevaqlkksadtlwdiqkdlkdl

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7dbkB (B:)
atlkekliapvaeeeatvpnnkitvvgvgqvgmacaisilgksladelalvdvledklkg
emmdlqhgslflqtpkivadkdysvtanskivvvtagvrqqegesrlnlvqrnvnvfkfi
ipqivkyspdciiivvsnpvdiltyvtwklsglpkhrvigsgcnldsarfrylmaeklgi
hpsschgwilgehgdssvavwsgvnvagvslqelnpemgtdndsenwkevhkmvvesaye
viklkgytnwaiglsvadliesmlknlsrihpvstmvkgmygienevflslpcilnargl
tsvinqklkddevaqlkksadtlwdiqkdlkdl

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7dbkC (C:)
atlkekliapvaeeeatvpnnkitvvgvgqvgmacaisilgksladelalvdvledklkg
emmdlqhgslflqtpkivadkdysvtanskivvvtagvrqqegesrlnlvqrnvnvfkfi
ipqivkyspdciiivvsnpvdiltyvtwklsglpkhrvigsgcnldsarfrylmaeklgi
hpsschgwilgehgdssvavwsgvnvagvslqelnpemgtdndsenwkevhkmvvesaye
viklkgytnwaiglsvadliesmlknlsrihpvstmvkgmygienevflslpcilnargl
tsvinqklkddevaqlkksadtlwdiqkdlkdl

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7dbkD (D:)
atlkekliapvaeeeatvpnnkitvvgvgqvgmacaisilgksladelalvdvledklkg
emmdlqhgslflqtpkivadkdysvtanskivvvtagvrqqegesrlnlvqrnvnvfkfi
ipqivkyspdciiivvsnpvdiltyvtwklsglpkhrvigsgcnldsarfrylmaeklgi
hpsschgwilgehgdssvavwsgvnvagvslqelnpemgtdndsenwkevhkmvvesaye
viklkgytnwaiglsvadliesmlknlsrihpvstmvkgmygienevflslpcilnargl
tsvinqklkddevaqlkksadtlwdiqkdlkdl

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7dbkE (E:)
atlkekliapvaeeeatvpnnkitvvgvgqvgmacaisilgksladelalvdvledklkg
emmdlqhgslflqtpkivadkdysvtanskivvvtagvrqqegesrlnlvqrnvnvfkfi
ipqivkyspdciiivvsnpvdiltyvtwklsglpkhrvigsgcnldsarfrylmaeklgi
hpsschgwilgehgdssvavwsgvnvagvslqelnpemgtdndsenwkevhkmvvesaye
viklkgytnwaiglsvadliesmlknlsrihpvstmvkgmygienevflslpcilnargl
tsvinqklkddevaqlkksadtlwdiqkdlkdl

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7dbkF (F:)
atlkekliapvaeeeatvpnnkitvvgvgqvgmacaisilgksladelalvdvledklkg
emmdlqhgslflqtpkivadkdysvtanskivvvtagvrqqegesrlnlvqrnvnvfkfi
ipqivkyspdciiivvsnpvdiltyvtwklsglpkhrvigsgcnldsarfrylmaeklgi
hpsschgwilgehgdssvavwsgvnvagvslqelnpemgtdndsenwkevhkmvvesaye
viklkgytnwaiglsvadliesmlknlsrihpvstmvkgmygienevflslpcilnargl
tsvinqklkddevaqlkksadtlwdiqkdlkdl

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7dbkG (G:)
atlkekliapvaeeeatvpnnkitvvgvgqvgmacaisilgksladelalvdvledklkg
emmdlqhgslflqtpkivadkdysvtanskivvvtagvrqqegesrlnlvqrnvnvfkfi
ipqivkyspdciiivvsnpvdiltyvtwklsglpkhrvigsgcnldsarfrylmaeklgi
hpsschgwilgehgdssvavwsgvnvagvslqelnpemgtdndsenwkevhkmvvesaye
viklkgytnwaiglsvadliesmlknlsrihpvstmvkgmygienevflslpcilnargl
tsvinqklkddevaqlkksadtlwdiqkdlkdl

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7dbkH (H:)
atlkekliapvaeeeatvpnnkitvvgvgqvgmacaisilgksladelalvdvledklkg
emmdlqhgslflqtpkivadkdysvtanskivvvtagvrqqegesrlnlvqrnvnvfkfi
ipqivkyspdciiivvsnpvdiltyvtwklsglpkhrvigsgcnldsarfrylmaeklgi
hpsschgwilgehgdssvavwsgvnvagvslqelnpemgtdndsenwkevhkmvvesaye
viklkgytnwaiglsvadliesmlknlsrihpvstmvkgmygienevflslpcilnargl
tsvinqklkddevaqlkksadtlwdiqkdlkdl