PDB entry 7a2n

View 7a2n on RCSB PDB site
Description: Crystal structure of the Fyn SH3 domain A95S-D99T mutant in space group P21
Class: protein binding
Keywords: beta barrel, SH3 domain, PROTEIN BINDING
Deposited on 2020-08-18, released 2021-08-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-08-25, with a file datestamp of 2021-08-20.
Experiment type: XRAY
Resolution: 1.4 Å
R-factor: N/A
AEROSPACI score: 0.62 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase Fyn
    Species: Homo sapiens [TaxId:9606]
    Gene: FYN
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06241 (0-59)
      • engineered mutation (12)
      • engineered mutation (16)
    Domains in SCOPe 2.08: d7a2na_
  • Chain 'B':
    Compound: Tyrosine-protein kinase Fyn
    Species: Homo sapiens [TaxId:9606]
    Gene: FYN
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06241 (0-59)
      • engineered mutation (12)
      • engineered mutation (16)
    Domains in SCOPe 2.08: d7a2nb_
  • Chain 'C':
    Compound: Tyrosine-protein kinase Fyn
    Species: Homo sapiens [TaxId:9606]
    Gene: FYN
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06241 (0-59)
      • engineered mutation (12)
      • engineered mutation (16)
    Domains in SCOPe 2.08: d7a2nc_
  • Chain 'D':
    Compound: Tyrosine-protein kinase Fyn
    Species: Homo sapiens [TaxId:9606]
    Gene: FYN
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06241 (0-59)
      • engineered mutation (12)
      • engineered mutation (16)
    Domains in SCOPe 2.08: d7a2nd_
  • Heterogens: FMT, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7a2nA (A:)
gvtlfvalydyesrtetdlsfhkgekfqilnssegdwwearslttgetgyipsnyvapvd

    Sequence, based on observed residues (ATOM records): (download) 
    >7a2nA (A:)
vtlfvalydyesrtetdlsfhkgekfqilnssegdwwearslttgetgyipsnyvapvd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7a2nB (B:)
gvtlfvalydyesrtetdlsfhkgekfqilnssegdwwearslttgetgyipsnyvapvd

    Sequence, based on observed residues (ATOM records): (download) 
    >7a2nB (B:)
gvtlfvalydyesrtetdlsfhkgekfqilnssegdwwearslttgetgyipsnyvapv

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7a2nC (C:)
gvtlfvalydyesrtetdlsfhkgekfqilnssegdwwearslttgetgyipsnyvapvd

    Sequence, based on observed residues (ATOM records): (download) 
    >7a2nC (C:)
tlfvalydyesrtetdlsfhkgekfqilnssegdwwearslttgetgyipsnyvapvd

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7a2nD (D:)
gvtlfvalydyesrtetdlsfhkgekfqilnssegdwwearslttgetgyipsnyvapvd

    Sequence, based on observed residues (ATOM records): (download) 
    >7a2nD (D:)
gvtlfvalydyesrtetdlsfhkgekfqilnssegdwwearslttgetgyipsnyvapv