PDB entry 6z0x

View 6z0x on RCSB PDB site
Description: HtrA1 inactive protease domain S328A with CARASIL mutations D174R R274Q
Class: hydrolase
Keywords: Hydrolase Protease HtrA family CARASIL mutations trimerization, HYDROLASE
Deposited on 2020-05-11, released 2021-05-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-05-19, with a file datestamp of 2021-05-14.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine protease HTRA1
    Species: Homo sapiens [TaxId:9606]
    Gene: HTRA1, HTRA, PRSS11
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92743 (21-235)
      • engineered mutation (34)
      • engineered mutation (134)
      • engineered mutation (188)
    Domains in SCOPe 2.08: d6z0xa_
  • Chain 'B':
    Compound: Serine protease HTRA1
    Species: Homo sapiens [TaxId:9606]
    Gene: HTRA1, HTRA, PRSS11
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92743
      • engineered mutation (34)
      • engineered mutation (134)
      • engineered mutation (188)
    Domains in SCOPe 2.08: d6z0xb_
  • Chain 'C':
    Compound: Serine protease HTRA1
    Species: Homo sapiens [TaxId:9606]
    Gene: HTRA1, HTRA, PRSS11
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92743 (21-End)
      • engineered mutation (34)
      • engineered mutation (134)
      • engineered mutation (188)
    Domains in SCOPe 2.08: d6z0xc_
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6z0xA (A:)
mgsshhhhhhssglvprgshmdpnslrhkynfiarvvekiapavvhielfrklpfskrev
pvasgsgfivsedglivtnahvvtnkhrvkvelkngatyeakikdvdekadialikidhq
gklpvlllgrsselqpgefvvaigspfslqntvttgivsttqrggkelglrnsdmdyiqt
daiinygnaggplvnldgevigintlkvtagisfaipsdkikkflteshdrqakgk

    Sequence, based on observed residues (ATOM records): (download) 
    >6z0xA (A:)
dpnslrhkynfiarvvekiapavvhielfrklpfskrevpvasgsgfivsedglivtnah
vvtnkhrvkvelkngatyeakikdvdekadialikidhqgklpvlllgrsselqpgefvv
aigspfslqntvttgivsttdmdyiqtdaiinygnaggplvnldgevigintlkvtagis
faipsdkikkflteshdrqakgk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6z0xB (B:)
mgsshhhhhhssglvprgshmdpnslrhkynfiarvvekiapavvhielfrklpfskrev
pvasgsgfivsedglivtnahvvtnkhrvkvelkngatyeakikdvdekadialikidhq
gklpvlllgrsselqpgefvvaigspfslqntvttgivsttqrggkelglrnsdmdyiqt
daiinygnaggplvnldgevigintlkvtagisfaipsdkikkflteshdrqakgk

    Sequence, based on observed residues (ATOM records): (download) 
    >6z0xB (B:)
slrhkynfiarvvekiapavvhielfrklpfskrevpvasgsgfivsedglivtnahvvt
nkhrvkvelkngatyeakikdvdekadialikidhqgklpvlllgrsselqpgefvvaig
spfslqntvttgivsttqrdmdyiqtdaiinygnaggplvnldgevigintlkvtagisf
aipsdkikkflteshdr

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6z0xC (C:)
mgsshhhhhhssglvprgshmdpnslrhkynfiarvvekiapavvhielfrklpfskrev
pvasgsgfivsedglivtnahvvtnkhrvkvelkngatyeakikdvdekadialikidhq
gklpvlllgrsselqpgefvvaigspfslqntvttgivsttqrggkelglrnsdmdyiqt
daiinygnaggplvnldgevigintlkvtagisfaipsdkikkflteshdrqakgk

    Sequence, based on observed residues (ATOM records): (download) 
    >6z0xC (C:)
dpnslrhkynfiarvvekiapavvhielfrklpfskrevpvasgsgfivsedglivtnah
vvtnkhrvkvelkngatyeakikdvdekadialikidhqgklpvlllgrsselqpgefvv
aigspfslqntvttgivsttqsdmdyiqtdaiinygnaggplvnldgevigintlkvtag
isfaipsdkikkflteshdr