PDB entry 6cbz

View 6cbz on RCSB PDB site
Description: Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Estradiol and GRIP Peptide
Class: transcription
Keywords: Breast Cancer, Steroid Receptor, Estrogen, Hormone, TRANSCRIPTION
Deposited on 2018-02-05, released 2018-02-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-02-26, with a file datestamp of 2020-02-21.
Experiment type: XRAY
Resolution: 1.65 Å
R-factor: N/A
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered mutation (232)
    Domains in SCOPe 2.08: d6cbza_
  • Chain 'B':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • conflict (3)
      • conflict (112)
      • engineered mutation (232)
    Domains in SCOPe 2.08: d6cbzb_
  • Chain 'C':
    Compound: GRIP peptide
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6CBZ
  • Chain 'D':
    Compound: GRIP peptide
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6CBZ (0-7)
  • Heterogens: EST, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6cbzA (A:)
slalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrv
pgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmvei
fdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitd
tlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplsdllleml
dahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6cbzA (A:)
sltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvpgfv
dltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifdml
latssrfrmmnlqgeefvclksiillnsgvytdhihrvldkitdtlihlmakagltlqqq
hqrlaqlllilshirhmsnkgmehlysmkcknvvplsdlllemldahrl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6cbzB (B:)
slaasltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrv
pgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkmvegmvei
fdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitd
tlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplsdllleml
dahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6cbzB (B:)
aasltadqmvsalldaeppilysfseasmmglltnladrelvhminwakrvpgfvdltlh
dqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkmvegmveifdmllatss
rfrmmnlqgeefvclksiillnsgvytkdhihrvldkitdtlihlmakagltlqqqhqrl
aqlllilshirhmsnkgmehlysmkcknvvplsdlllemldahr

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.