PDB entry 6bfq

View 6bfq on RCSB PDB site
Description: The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies
Class: immune system
Keywords: cytokine-Fab complex, Pulmonary Alveolar Proteinosis, receptor assembly, autoantibodies, IMMUNE SYSTEM
Deposited on 2017-10-26, released 2018-09-12
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-09-12, with a file datestamp of 2018-09-07.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6BFQ
  • Chain 'B':
    Compound: Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6BFQ
    Domains in SCOPe 2.07: d6bfqb1, d6bfqb2
  • Chain 'C':
    Compound: Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6BFQ
  • Chain 'D':
    Compound: Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6BFQ
    Domains in SCOPe 2.07: d6bfqd1, d6bfqd2
  • Chain 'E':
    Compound: Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6BFQ
  • Chain 'F':
    Compound: Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6BFQ
    Domains in SCOPe 2.07: d6bfqf1, d6bfqf2
  • Chain 'G':
    Compound: granulocyte-macrophage colony-stimulating factor
    Species: Homo sapiens [TaxId:9606]
    Gene: CSF2, GMCSF
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6bfqg1, d6bfqg2
  • Chain 'H':
    Compound: Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6BFQ
  • Chain 'I':
    Compound: granulocyte-macrophage colony-stimulating factor
    Species: Homo sapiens [TaxId:9606]
    Gene: CSF2, GMCSF
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6bfqi1, d6bfqi2
  • Chain 'J':
    Compound: granulocyte-macrophage colony-stimulating factor
    Species: Homo sapiens [TaxId:9606]
    Gene: CSF2, GMCSF
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6bfqj1, d6bfqj2
  • Chain 'K':
    Compound: granulocyte-macrophage colony-stimulating factor
    Species: Homo sapiens [TaxId:9606]
    Gene: CSF2, GMCSF
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6bfqk1, d6bfqk2
  • Chain 'L':
    Compound: Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6BFQ
    Domains in SCOPe 2.07: d6bfql1, d6bfql2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6bfqB (B:)
mdiqmtqspssvsasvgdrvtitcrasqginrrlawyqqkpgkapkrliyavstlqsgvp
srfngsgsgtdftltvnnvqpddlamyfclqsnnypltfgggtkveikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6bfqB (B:)
diqmtqspssvsasvgdrvtitcrasqginrrlawyqqkpgkapkrliyavstlqsgvps
rfngsgsgtdftltvnnvqpddlamyfclqsnnypltfgggtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrg

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6bfqD (D:)
mdiqmtqspssvsasvgdrvtitcrasqginrrlawyqqkpgkapkrliyavstlqsgvp
srfngsgsgtdftltvnnvqpddlamyfclqsnnypltfgggtkveikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6bfqD (D:)
diqmtqspssvsasvgdrvtitcrasqginrrlawyqqkpgkapkrliyavstlqsgvps
rfngsgsgtdftltvnnvqpddlamyfclqsnnypltfgggtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6bfqF (F:)
mdiqmtqspssvsasvgdrvtitcrasqginrrlawyqqkpgkapkrliyavstlqsgvp
srfngsgsgtdftltvnnvqpddlamyfclqsnnypltfgggtkveikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6bfqF (F:)
diqmtqspssvsasvgdrvtitcrasqginrrlawyqqkpgkapkrliyavstlqsgvps
rfngsgsgtdftltvnnvqpddlamyfclqsnnypltfgggtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6bfqG (G:)
aparspspstqpwehvnaiqearrllnlsrdtaaemnetvevisemfdlqeptclqtrle
lykqglrgsltklkgpltmmashykqhcpptpetscatqiitfesfkenlkdfllvipfd
cwepvqe

    Sequence, based on observed residues (ATOM records): (download) 
    >6bfqG (G:)
rrllnmnetvevisemfdlqeptclqtrlelykqglrgsltklkgpltmmashykqhcpp
tpetscatqiitfesfkenlkdfllvipfdcwep

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >6bfqI (I:)
aparspspstqpwehvnaiqearrllnlsrdtaaemnetvevisemfdlqeptclqtrle
lykqglrgsltklkgpltmmashykqhcpptpetscatqiitfesfkenlkdfllvipfd
cwepvqe

    Sequence, based on observed residues (ATOM records): (download) 
    >6bfqI (I:)
rrllnlmnetvevisemfdlqeptclqtrlelykqglrgsltklkgpltmmashykqhcp
ptpetscatqiitfesfkenlkdfllvipfdcwe

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >6bfqJ (J:)
aparspspstqpwehvnaiqearrllnlsrdtaaemnetvevisemfdlqeptclqtrle
lykqglrgsltklkgpltmmashykqhcpptpetscatqiitfesfkenlkdfllvipfd
cwepvqe

    Sequence, based on observed residues (ATOM records): (download) 
    >6bfqJ (J:)
iqearrllnlsrdtmnetvevisemfdlqeptclqtrlelykqglrgsltklkgpltmma
shykqhcpptpetscatqiitfesfkenlkdfllvipfdcwe

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >6bfqK (K:)
aparspspstqpwehvnaiqearrllnlsrdtaaemnetvevisemfdlqeptclqtrle
lykqglrgsltklkgpltmmashykqhcpptpetscatqiitfesfkenlkdfllvipfd
cwepvqe

    Sequence, based on observed residues (ATOM records): (download) 
    >6bfqK (K:)
iqearrllnlsraemnetvevisemfdlqeptclqtrlelykqglrgsltklkgpltmma
shykqhcpptpetscatqiitfesfkenlkdfllvipfdcwe

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6bfqL (L:)
mdiqmtqspssvsasvgdrvtitcrasqginrrlawyqqkpgkapkrliyavstlqsgvp
srfngsgsgtdftltvnnvqpddlamyfclqsnnypltfgggtkveikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6bfqL (L:)
diqmtqspssvsasvgdrvtitcrasqginrrlawyqqkpgkapkrliyavstlqsgvps
rfngsgsgtdftltvnnvqpddlamyfclqsnnypltfgggtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrg