PDB entry 6b0z

View 6b0z on RCSB PDB site
Description: IDH1 R132H mutant in complex with IDH305
Class: oxidoreductase
Keywords: Isocitrate dehydrogenase, Rossmann fold, NADPH, inhibitor, OXIDOREDUCTASE
Deposited on 2017-09-15, released 2017-11-08
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-11-08, with a file datestamp of 2017-11-03.
Experiment type: XRAY
Resolution: 2.33 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: isocitrate dehydrogenase [nadp] cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: IDH1, PICD
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75874
      • engineered mutation (134)
    Domains in SCOPe 2.06: d6b0za_
  • Chain 'B':
    Compound: isocitrate dehydrogenase [nadp] cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: IDH1, PICD
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75874
      • engineered mutation (134)
    Domains in SCOPe 2.06: d6b0zb_
  • Chain 'C':
    Compound: isocitrate dehydrogenase [nadp] cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: IDH1, PICD
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75874 (Start-416)
      • engineered mutation (134)
    Domains in SCOPe 2.06: d6b0zc_
  • Chain 'D':
    Compound: isocitrate dehydrogenase [nadp] cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: IDH1, PICD
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75874
      • engineered mutation (134)
    Domains in SCOPe 2.06: d6b0zd_
  • Heterogens: NDP, C81, FLC, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6b0zA (A:)
gpgmskkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvt
kdaaeaikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickni
prlvsgwvkpiiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeeggg
vamgmynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyks
qfeaqkiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvc
pdgktveaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffan
aleevsietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl

    Sequence, based on observed residues (ATOM records): (download) 
    >6b0zA (A:)
kkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaae
aikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvs
gwvkpiiighhaatdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgmynqdks
iedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaqkiwyeh
rliddmvaqamkseggfiwacknqsdsvaqgygslgmmtsvlvcpdgktveaeaahgtvt
rhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleevsietieagfmt
kdlaacikglpnvqrsdylntfefmdklgenlkiklaqa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6b0zB (B:)
gpgmskkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvt
kdaaeaikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickni
prlvsgwvkpiiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeeggg
vamgmynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyks
qfeaqkiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvc
pdgktveaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffan
aleevsietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl

    Sequence, based on observed residues (ATOM records): (download) 
    >6b0zB (B:)
kkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaae
aikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvs
gwvkpiiighhadqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgmyn
qdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaqki
wyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdgktve
aeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleevsi
etieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqak

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6b0zC (C:)
gpgmskkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvt
kdaaeaikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickni
prlvsgwvkpiiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeeggg
vamgmynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyks
qfeaqkiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvc
pdgktveaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffan
aleevsietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl

    Sequence, based on observed residues (ATOM records): (download) 
    >6b0zC (C:)
kkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaae
aikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvs
gwvkpiiighhadqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgmyn
qdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaqki
wyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdgktve
aeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleevsi
etieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6b0zD (D:)
gpgmskkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvt
kdaaeaikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickni
prlvsgwvkpiiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeeggg
vamgmynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyks
qfeaqkiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvc
pdgktveaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffan
aleevsietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl

    Sequence, based on observed residues (ATOM records): (download) 
    >6b0zD (D:)
kkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaae
aikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvs
gwvkpiiighharatdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgmynqdk
siedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaqkiwye
hrliddmvaqamkseggfiwacknqsdsvaqgygslgmmtsvlvcpdgktveaeaahgtv
trhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleevsietieagfm
tkdlaacikglpnvqrsdylntfefmdklgenlkiklaq