SCOPe 2.06: Domain d6b0za_: 6b0z A:

Lineage for d6b0za_ (6b0z A:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families)
   the constituent families form similar dimers

5. Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 proteins)
   the active site is between the two identical subunits

6. Protein NADP-dependent isocitrate dehydrogenase [82524] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [110715] (18 PDB entries)
   Uniprot O75874

8. Domain d6b0za_: 6b0z A: [341343]
   automated match to d1t0la_
   complexed with c81, flc, ndp; mutant

Details for d6b0za_

PDB Entry: 6b0z, 2.33 Å

PDB Description: idh1 r132h mutant in complex with idh305

PDB Compounds: (A:) isocitrate dehydrogenase [nadp] cytoplasmic

SCOPe Domain Sequences for d6b0za_:

Sequence, based on SEQRES records:

>d6b0za_ c.77.1.1 (A:) NADP-dependent isocitrate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
kkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaae
aikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvs
gwvkpiiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgm
ynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaq
kiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdgkt
veaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleev
sietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqa

Sequence, based on observed residues (ATOM records):

>d6b0za_ c.77.1.1 (A:) NADP-dependent isocitrate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
kkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaae
aikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvs
gwvkpiiighhaatdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgmynqdks
iedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaqkiwyeh
rliddmvaqamkseggfiwacknqsdsvaqgygslgmmtsvlvcpdgktveaeaahgtvt
rhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleevsietieagfmt
kdlaacikglpnvqrsdylntfefmdklgenlkiklaqa

Timeline for d6b0za_:

• d6b0za_ is new in SCOPe 2.06-stable
  
• d6b0za_ appears in SCOPe 2.07
  
• d6b0za_ appears in the current release, SCOPe 2.08