PDB entry 5x8x

View 5x8x on RCSB PDB site
Description: Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With Compound A.
Class: transferase/inhibitor
Keywords: Inhibitor, Ternary Complex, Nuclear Receptor, TRANSFERASE-INHIBITOR complex
Deposited on 2017-03-03, released 2017-06-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-06-17, with a file datestamp of 2020-06-12.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Nuclear receptor ROR-gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: RORC, NR1F3, RORG, RZRG
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51449
      • engineered mutation (208)
      • engineered mutation (212)
    Domains in SCOPe 2.08: d5x8xa_
  • Chain 'B':
    Compound: Nuclear receptor corepressor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: NCOR2, CTG26
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Nuclear receptor ROR-gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: RORC, NR1F3, RORG, RZRG
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51449
      • engineered mutation (208)
      • engineered mutation (212)
    Domains in SCOPe 2.08: d5x8xc_
  • Chain 'D':
    Compound: Nuclear receptor corepressor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: NCOR2, CTG26
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Nuclear receptor ROR-gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: RORC, NR1F3, RORG, RZRG
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51449
      • engineered mutation (208)
      • engineered mutation (212)
    Domains in SCOPe 2.08: d5x8xe_
  • Chain 'F':
    Compound: Nuclear receptor corepressor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: NCOR2, CTG26
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Nuclear receptor ROR-gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: RORC, NR1F3, RORG, RZRG
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51449
      • engineered mutation (208)
      • engineered mutation (212)
    Domains in SCOPe 2.08: d5x8xg_
  • Chain 'H':
    Compound: Nuclear receptor corepressor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: NCOR2, CTG26
    Database cross-references and differences (RAF-indexed):
  • Heterogens: 82O, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5x8xA (A:)
eapyaslteiehlvqsvcksyretcqlrledllrqrsnifsreevtgyqrksmwemwerc
ahhlteaiqyvvefakrlsgfmelcqndqivllkagamevvlvrmcraynadnrtvffeg
kyggmelfralgcselissifdfshslsalhfsedeialytalvlinahrpglqekrkve
qlqynlelafhhhlckthrqsilaklppagklaslcsqhverlqifqhlhpivvqaafpp
lykelfstetespvglsk

    Sequence, based on observed residues (ATOM records): (download) 
    >5x8xA (A:)
slteiehlvqsvcksyretcqlrledllrqrsnifsreevtgyqrksmwemwercahhlt
eaiqyvvefakrlsgfmelcqndqivllkagamevvlvrmcraynadnrtvffegkyggm
elfralgcselissifdfshslsalhfsedeialytalvlinahrpglqekrkveqlqyn
lelafhhhlckthrqsilaklppagklaslcsqhverlqifqhlhpiv

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5x8xC (C:)
eapyaslteiehlvqsvcksyretcqlrledllrqrsnifsreevtgyqrksmwemwerc
ahhlteaiqyvvefakrlsgfmelcqndqivllkagamevvlvrmcraynadnrtvffeg
kyggmelfralgcselissifdfshslsalhfsedeialytalvlinahrpglqekrkve
qlqynlelafhhhlckthrqsilaklppagklaslcsqhverlqifqhlhpivvqaafpp
lykelfstetespvglsk

    Sequence, based on observed residues (ATOM records): (download) 
    >5x8xC (C:)
slteiehlvqsvcksyretcqlrledllrqrsnifsreevtgyqrksmwemwercahhlt
eaiqyvvefakrlsgfmelcqndqivllkagamevvlvrmcraynadnrtvffegkyggm
elfralgcselissifdfshslsalhfsedeialytalvlinahrpglqekrkveqlqyn
lelafhhhlckthrqsilaklppagklaslcsqhverlqifqhlhpiv

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >5x8xE (E:)
eapyaslteiehlvqsvcksyretcqlrledllrqrsnifsreevtgyqrksmwemwerc
ahhlteaiqyvvefakrlsgfmelcqndqivllkagamevvlvrmcraynadnrtvffeg
kyggmelfralgcselissifdfshslsalhfsedeialytalvlinahrpglqekrkve
qlqynlelafhhhlckthrqsilaklppagklaslcsqhverlqifqhlhpivvqaafpp
lykelfstetespvglsk

    Sequence, based on observed residues (ATOM records): (download) 
    >5x8xE (E:)
slteiehlvqsvcksyretcqlrledllrqrsnifsreevtgyqrksmwemwercahhlt
eaiqyvvefakrlsgfmelcqndqivllkagamevvlvrmcraynadnrtvffegkyggm
elfralgcselissifdfshslsalhfsedeialytalvlinahrpglqekrkveqlqyn
lelafhhhlckthrqsilaklppagklaslcsqhverlqifqhlhpiv

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >5x8xG (G:)
eapyaslteiehlvqsvcksyretcqlrledllrqrsnifsreevtgyqrksmwemwerc
ahhlteaiqyvvefakrlsgfmelcqndqivllkagamevvlvrmcraynadnrtvffeg
kyggmelfralgcselissifdfshslsalhfsedeialytalvlinahrpglqekrkve
qlqynlelafhhhlckthrqsilaklppagklaslcsqhverlqifqhlhpivvqaafpp
lykelfstetespvglsk

    Sequence, based on observed residues (ATOM records): (download) 
    >5x8xG (G:)
lteiehlvqsvcksyretcqlrledllrqrsnifsreevtgyqrksmwemwercahhlte
aiqyvvefakrlsgfmelcqndqivllkagamevvlvrmcraynadnrtvffegkyggme
lfralgcselissifdfshslsalhfsedeialytalvlinahrpglqekrkveqlqynl
elafhhhlckthrqsilaklppagklaslcsqhverlqifqhlh

  • Chain 'H':
    No sequence available.