PDB entry 5uor

View 5uor on RCSB PDB site
Description: Structure-Based Design of ASK1 Inhibitors as Potential First-in-Class Agents for Heart Failure
Class: transferase/transferase inhibitor
Keywords: TRANSFERASE, METAL-BINDING, APOPTOSIS, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2017-02-01, released 2017-06-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 2.75 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: mitogen-activated protein kinase kinase kinase 5
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP3K5, ASK1, MAPKKK5, MEKK5
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5uora_
  • Chain 'B':
    Compound: mitogen-activated protein kinase kinase kinase 5
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP3K5, ASK1, MAPKKK5, MEKK5
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5uorb_
  • Heterogens: SO4, 8GV, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5uorA (A:)
lleydyeydengdrvvlgkgtygivyagrdlsnqvriaikeiperdsrysqplheeialh
khlkhknivqylgsfsengfikifmeqvpggslsallrskwgplkdneqtigfytkqile
glkylhdnqivhrdikgdnvlintysgvlkisdfgtskrlaginpctetftgtlqymape
iidkgprgygkaadiwslgctiiematgkppfyelgepqaamfkvgmfkvhpeipesmsa
eakafilkcfepdpdkracandllvdeflk

    Sequence, based on observed residues (ATOM records): (download) 
    >5uorA (A:)
leydyeydengdrvvlgkgtygivyagrdlsnqvriaikeiperdsrysqplheeialhk
hlkhknivqylgsfsengfikifmeqvpggslsallrskwgplkdneqtigfytkqileg
lkylhdnqivhrdikgdnvlintysgvlkisdfgtskrlftgtlqymapeiidygkaadi
wslgctiiematgkppfyeamfkvgmfkvhpeipesmsaeakafilkcfepdpdkracan
dllvdeflk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5uorB (B:)
lleydyeydengdrvvlgkgtygivyagrdlsnqvriaikeiperdsrysqplheeialh
khlkhknivqylgsfsengfikifmeqvpggslsallrskwgplkdneqtigfytkqile
glkylhdnqivhrdikgdnvlintysgvlkisdfgtskrlaginpctetftgtlqymape
iidkgprgygkaadiwslgctiiematgkppfyelgepqaamfkvgmfkvhpeipesmsa
eakafilkcfepdpdkracandllvdeflk

    Sequence, based on observed residues (ATOM records): (download) 
    >5uorB (B:)
lleydyeydengdrvvlgkgtygivyagrdlsnqvriaikeiperdsrysqplheeialh
khlkhknivqylgsfsengfikifmeqvpggslsallrskwgplkdneqtigfytkqile
glkylhdnqivhrdikgdnvlintysgvlkisdfgtskrltftgtlqymapeiidkgprg
ygkaadiwslgctiiematgkppfyelgepqaamfkvgmfkvhpeipesmsaeakafilk
cfepdpdkracandllvdeflk