PDB entry 5nh3

View 5nh3 on RCSB PDB site
Description: CRYSTAL STRUCTURE OF THE Activin receptor type-2A LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB FV
Class: transferase
Keywords: OTHER, EPITOPE MAPPING, transferase
Deposited on 2017-03-21, released 2017-11-15
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Activin receptor type-2A
    Species: Homo sapiens [TaxId:9606]
    Gene: ACVR2A, ACVR2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5nh3a_
  • Chain 'B':
    Compound: Activin receptor type-2A
    Species: Homo sapiens [TaxId:9606]
    Gene: ACVR2A, ACVR2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5nh3b_
  • Chain 'H':
    Compound: anti-human ActRIIB mAb BYM338 Fv heavy-chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5NH3 (0-End)
    Domains in SCOPe 2.06: d5nh3h1, d5nh3h2
  • Chain 'I':
    Compound: anti-human ActRIIB mAb BYM338 Fv heavy-chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5NH3 (0-End)
    Domains in SCOPe 2.06: d5nh3i1, d5nh3i2
  • Chain 'L':
    Compound: anti-human ActRIIB mAb BYM338 Fv light-chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5NH3
    Domains in SCOPe 2.06: d5nh3l1, d5nh3l2
  • Chain 'M':
    Compound: anti-human ActRIIB mAb BYM338 Fv light-chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5NH3
    Domains in SCOPe 2.06: d5nh3m1, d5nh3m2
  • Heterogens: NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5nh3A (A:)
ailgrsetqeclffnanwekdrtnqtgvepcygdkdkrrhcfatwknisgsieivkqgcw
lddincydrtdcvekkdspevyfcccegnmcnekfsyfpemevtqptsnpvtpkppefrh
ds

    Sequence, based on observed residues (ATOM records): (download) 
    >5nh3A (A:)
setqeclffnanwekdrtnqtgvepcygdkdkrrhcfatwknisgsieivkqgcwlddin
cydrtdcvekkdspevyfcccegnmcnekfsyfp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5nh3B (B:)
ailgrsetqeclffnanwekdrtnqtgvepcygdkdkrrhcfatwknisgsieivkqgcw
lddincydrtdcvekkdspevyfcccegnmcnekfsyfpemevtqptsnpvtpkppefrh
ds

    Sequence, based on observed residues (ATOM records): (download) 
    >5nh3B (B:)
setqeclffnanwekdrtnqtgvepcygdkdkrrhcfatwknisgsieivkqgcwlddin
cydrtdcvekkdspevyfcccegnmcnekfsyfpe

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >5nh3H (H:)
evqlvqsgaevkkpgasvkvsckasgytftssyinwvrqapgqglewmgtinpvsgstsy
aqkfqgrvtmtrdtsistaymelsrlrsddtavyycarggwfdywgqgtlvtvsshhhhh
h

    Sequence, based on observed residues (ATOM records): (download) 
    >5nh3H (H:)
evqlvqsgaevkkpgasvkvsckasgytftssyinwvrqapgqglewmgtinpvsgstsy
aqkfqgrvtmtrdtsistaymelsrlrsddtavyycarggwfdywgqgtlvtvs

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >5nh3I (I:)
evqlvqsgaevkkpgasvkvsckasgytftssyinwvrqapgqglewmgtinpvsgstsy
aqkfqgrvtmtrdtsistaymelsrlrsddtavyycarggwfdywgqgtlvtvsshhhhh
h

    Sequence, based on observed residues (ATOM records): (download) 
    >5nh3I (I:)
evqlvqsgaevkkpgasvkvsckasgytftssyinwvrqapgqglewmgtinpvsgstsy
aqkfqgrvtmtrdtsistaymelsrlrsddtavyycarggwfdywgqgtlvtvs

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >5nh3L (L:)
qsaltqpasvsgspgqsitisctgtssdvgsynyvnwyqqhpgkapklmiygvskrpsgv
snrfsgsksgntasltisglqaedeadyycgtfaggsyygvfgggtkltvlwshpqfek

    Sequence, based on observed residues (ATOM records): (download) 
    >5nh3L (L:)
saltqpasvsgspgqsitisctgtssdvgsynyvnwyqqhpgkapklmiygvskrpsgvs
nrfsgsksgntasltisglqaedeadyycgtfaggsyygvfgggtkltvlw

  • Chain 'M':
    Sequence, based on SEQRES records: (download) 
    >5nh3M (M:)
qsaltqpasvsgspgqsitisctgtssdvgsynyvnwyqqhpgkapklmiygvskrpsgv
snrfsgsksgntasltisglqaedeadyycgtfaggsyygvfgggtkltvlwshpqfek

    Sequence, based on observed residues (ATOM records): (download) 
    >5nh3M (M:)
saltqpasvsgspgqsitisctgtssdvgsynyvnwyqqhpgkapklmiygvskrpsgvs
nrfsgsksgntasltisglqaedeadyycgtfaggsyygvfgggtkltvlw