PDB entry 5kvu

View 5kvu on RCSB PDB site
Description: Crystal structure of isocitrate dehydrogenase-2 in complex with NADP(+) from Mycobacterium tuberculosis
Class: oxidoreductase
Keywords: ICD, OXIDOREDUCTASE, Structural Genomics, TB Structural Genomics Consortium, TBSGC
Deposited on 2016-07-15, released 2017-07-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-07-19, with a file datestamp of 2017-07-14.
Experiment type: XRAY
Resolution: 2.66 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: isocitrate dehydrogenase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: icd2, Rv0066c, LH57_00380
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5kvua_
  • Chain 'B':
    Compound: isocitrate dehydrogenase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: icd2, Rv0066c, LH57_00380
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5kvub_
  • Chain 'C':
    Compound: isocitrate dehydrogenase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: icd2, Rv0066c, LH57_00380
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5kvuc_
  • Chain 'D':
    Compound: isocitrate dehydrogenase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: icd2, Rv0066c, LH57_00380
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5kvud_
  • Heterogens: NAP, MLT, EDO, MLA, SIN, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5kvuA (A:)
msaeqptiiytltdeapllatyaflpivrafaepagikieasdisvaarilaefpdylte
eqrvpdnlaelgrltqlpdtniiklpnisasvpqlvaaikelqdkgyavpdypadpktdq
ekaikeryarclgsavnpvlrqgnsdrrapkavkeyarkhphsmgewsmasrthvahmrh
gdfyageksmtldrarnvrmellaksgktivlkpevplddgdvidsmfmskkalcdfyee
qmqdafetgvmfslhvkatmmkvshpivfghavrifykdafakhqelfddlgvnvnngls
dlyskieslpasqrdeiiedlhrchehrpelamvdsargisnfhspsdvivdasmpamir
aggkmygadgklkdtkavnpestfsriyqeiinfcktngqfdpttmgtvpnvglmaqqae
eygshdktfeipedgvanivdvatgevlltenveagdiwrmcivkdapirdwvklavtra
risgmpvlfwldpyrphenelikkvktylkdhdtegldiqimsqvrsmrytcerlvrgld
tiaatgnilrdyltdlfpilelgtsakmlsvvplmagggmyetgaggsapkhvkqlveen
hlrwdslgeflalgagfedigiktgnerakllgktldaaigklldndkspsrktgeldnr
gsqfylamywaqelaaqtddqqlaehfasladvltknedvivreltevqgepvdiggyya
pdsdmttavmrpsktfnaaleavqg

    Sequence, based on observed residues (ATOM records): (download) 
    >5kvuA (A:)
qptiiytltdeapllatyaflpivrafaepagikieasdisvaarilaefpdylteeqrv
pdnlaelgrltqlpdtniiklpnisasvpqlvaaikelqdkgyavpdypadptdqekaik
eryarclgsavnpvlrqgnsdrrapkavkeyarkhphsmgewsmasrthvahmrhgdfya
geksmtldrarnvrmellaksgktivlkpevplddgdvidsmfmskkalcdfyeeqmqda
fetgvmfslhvkatmmkvshpivfghavrifykdafakhqelfddlgvnvnnglsdlysk
ieslpasqrdeiiedlhrchehrpelamvdsargisnfhspsdvivdasmpamiraggkm
ygadgklkdtkavnpestfsriyqeiinfcktngqfdpttmgtvpnvglmaqqaeeygsh
dktfeipedgvanivdvatgevlltenveagdiwrmcivkdapirdwvklavtrarisgm
pvlfwldpyrphenelikkvktylkdhdtegldiqimsqvrsmrytcerlvrgldtiaat
gnilrdyltdlfpilelgtsakmlsvvplmagggmyetgaggsapkhvkqlveenhlrwd
slgeflalgagfedigiktgnerakllgktldaaigklldndkspsrktgeldnrgsqfy
lamywaqelaaqtddqqlaehfasladvltknedvivreltevqgepvdiggyyapdsdm
ttavmrpsktfnaaleav

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5kvuB (B:)
msaeqptiiytltdeapllatyaflpivrafaepagikieasdisvaarilaefpdylte
eqrvpdnlaelgrltqlpdtniiklpnisasvpqlvaaikelqdkgyavpdypadpktdq
ekaikeryarclgsavnpvlrqgnsdrrapkavkeyarkhphsmgewsmasrthvahmrh
gdfyageksmtldrarnvrmellaksgktivlkpevplddgdvidsmfmskkalcdfyee
qmqdafetgvmfslhvkatmmkvshpivfghavrifykdafakhqelfddlgvnvnngls
dlyskieslpasqrdeiiedlhrchehrpelamvdsargisnfhspsdvivdasmpamir
aggkmygadgklkdtkavnpestfsriyqeiinfcktngqfdpttmgtvpnvglmaqqae
eygshdktfeipedgvanivdvatgevlltenveagdiwrmcivkdapirdwvklavtra
risgmpvlfwldpyrphenelikkvktylkdhdtegldiqimsqvrsmrytcerlvrgld
tiaatgnilrdyltdlfpilelgtsakmlsvvplmagggmyetgaggsapkhvkqlveen
hlrwdslgeflalgagfedigiktgnerakllgktldaaigklldndkspsrktgeldnr
gsqfylamywaqelaaqtddqqlaehfasladvltknedvivreltevqgepvdiggyya
pdsdmttavmrpsktfnaaleavqg

    Sequence, based on observed residues (ATOM records): (download) 
    >5kvuB (B:)
ptiiytltdeapllatyaflpivrafaepagikieasdisvaarilaefpdylteeqrvp
dnlaelgrltqlpdtniiklpnisasvpqlvaaikelqdkgyavpdypadpktdqekaik
eryarclgsavnpvlrqgnsdrrapkavkeyarkhphsmgewsmasrthvahmrhgdfya
geksmtldrarnvrmellaksgktivlkpevplddgdvidsmfmskkalcdfyeeqmqda
fetgvmfslhvkatmmkvshpivfghavrifykdafakhqelfddlgvnvnnglsdlysk
ieslpasqrdeiiedlhrchehrpelamvdsargisnfhspsdvivdasmpamiraggkm
ygadgklkdtkavnpestfsriyqeiinfcktngqfdpttmgtvpnvglmaqqaeeygsh
dktfeipedgvanivdvatgevlltenveagdiwrmcivkdapirdwvklavtrarisgm
pvlfwldpyrphenelikkvktylkdhdtegldiqimsqvrsmrytcerlvrgldtiaat
gnilrdyltdlfpilelgtsakmlsvvplmagggmyetgaggsapkhvkqlveenhlrwd
slgeflalgagfedigiktgnerakllgktldaaigklldndkspsrktgeldnrgsqfy
lamywaqelaaqtddqqlaehfasladvltknedvivreltevqgepvdiggyyapdsdm
ttavmrpsktfnaaleav

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5kvuC (C:)
msaeqptiiytltdeapllatyaflpivrafaepagikieasdisvaarilaefpdylte
eqrvpdnlaelgrltqlpdtniiklpnisasvpqlvaaikelqdkgyavpdypadpktdq
ekaikeryarclgsavnpvlrqgnsdrrapkavkeyarkhphsmgewsmasrthvahmrh
gdfyageksmtldrarnvrmellaksgktivlkpevplddgdvidsmfmskkalcdfyee
qmqdafetgvmfslhvkatmmkvshpivfghavrifykdafakhqelfddlgvnvnngls
dlyskieslpasqrdeiiedlhrchehrpelamvdsargisnfhspsdvivdasmpamir
aggkmygadgklkdtkavnpestfsriyqeiinfcktngqfdpttmgtvpnvglmaqqae
eygshdktfeipedgvanivdvatgevlltenveagdiwrmcivkdapirdwvklavtra
risgmpvlfwldpyrphenelikkvktylkdhdtegldiqimsqvrsmrytcerlvrgld
tiaatgnilrdyltdlfpilelgtsakmlsvvplmagggmyetgaggsapkhvkqlveen
hlrwdslgeflalgagfedigiktgnerakllgktldaaigklldndkspsrktgeldnr
gsqfylamywaqelaaqtddqqlaehfasladvltknedvivreltevqgepvdiggyya
pdsdmttavmrpsktfnaaleavqg

    Sequence, based on observed residues (ATOM records): (download) 
    >5kvuC (C:)
qptiiytltdeapllatyaflpivrafaepagikieasdisvaarilaefpdylteeqrv
pdnlaelgrltqlpdtniiklpnisasvpqlvaaikelqdkgyavpdypadpktdqekai
keryarclgsavnpvlrqgnsdrrapkavkeyarkhphsmgewsmasrthvahmrhgdfy
ageksmtldrarnvrmellaksgktivlkpevplddgdvidsmfmskkalcdfyeeqmqd
afetgvmfslhvkatmpivfghavrifykdafakhqelfddlgvnvnnglsdlyskiesl
pasqrdeiiedlhrchehrpelamvdsargisnfhspsdvivdasmpamiraggkmygad
gklkdtkavnpestfsriyqeiinfcktngqfdpttmgtvpnvglmaqqaeeygshdktf
eipedgvanivdvatgevlltenveagdiwrmcivkdapirdwvklavtrarisgmpvlf
wldpyrphenelikkvktylkdhdtegldiqimsqvrsmrytcerlvrgldtiaatgnil
rdyltdlfpilelgtsakmlsvvplmagggmyetgaggsapkhvkqlveenhlrwdslge
flalgagfedigiktgnerakllgktldaaigklldndkspsrktgeldnrgsqfylamy
waqelaaqtddqqlaehfasladvltknedvivreltevqgepvdiggyyapdsdmttav
mrpsktfnaaleav

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5kvuD (D:)
msaeqptiiytltdeapllatyaflpivrafaepagikieasdisvaarilaefpdylte
eqrvpdnlaelgrltqlpdtniiklpnisasvpqlvaaikelqdkgyavpdypadpktdq
ekaikeryarclgsavnpvlrqgnsdrrapkavkeyarkhphsmgewsmasrthvahmrh
gdfyageksmtldrarnvrmellaksgktivlkpevplddgdvidsmfmskkalcdfyee
qmqdafetgvmfslhvkatmmkvshpivfghavrifykdafakhqelfddlgvnvnngls
dlyskieslpasqrdeiiedlhrchehrpelamvdsargisnfhspsdvivdasmpamir
aggkmygadgklkdtkavnpestfsriyqeiinfcktngqfdpttmgtvpnvglmaqqae
eygshdktfeipedgvanivdvatgevlltenveagdiwrmcivkdapirdwvklavtra
risgmpvlfwldpyrphenelikkvktylkdhdtegldiqimsqvrsmrytcerlvrgld
tiaatgnilrdyltdlfpilelgtsakmlsvvplmagggmyetgaggsapkhvkqlveen
hlrwdslgeflalgagfedigiktgnerakllgktldaaigklldndkspsrktgeldnr
gsqfylamywaqelaaqtddqqlaehfasladvltknedvivreltevqgepvdiggyya
pdsdmttavmrpsktfnaaleavqg

    Sequence, based on observed residues (ATOM records): (download) 
    >5kvuD (D:)
qptiiytltdeapllatyaflpivrafaepagikieasdisvaarilaefpdylteeqrv
pdnlaelgrltqlpdtniiklpnisasvpqlvaaikelqdkgyavpdypapktdqekaik
eryarclgsavnpvlrqgnsdrrapkavkeyarkhphsmgewsmasrthvahmrhgdfya
geksmtldrarnvrmellaksgktivlkpevplddgdvidsmfmskkalcdfyeeqmqda
fetgvmfslhvkatmpivfghavrifykdafakhqelfddlgvnvnnglsdlyskieslp
asqrdeiiedlhrchehrpelamvdsargisnfhspsdvivdasmpamiraggkmygadg
klkdtkavnpestfsriyqeiinfcktngqfdpttmgtvpnvglmaqqaeeygshdktfe
ipedgvanivdvatgevlltenveagdiwrmcivkdapirdwvklavtrarisgmpvlfw
ldpyrphenelikkvktylkdhdtegldiqimsqvrsmrytcerlvrgldtiaatgnilr
dyltdlfpilelgtsakmlsvvplmagggmyetgaggsapkhvkqlveenhlrwdslgef
lalgagfedigiktgnerakllgktldaaigklldndkspsrktgeldnrgsqfylamyw
aqelaaqtddqqlaehfasladvltknedvivreltevqgepvdiggyyapdsdmttavm
rpsktfnaalea