PDB entry 4z78
View 4z78 on RCSB PDB site
Description: Weak TCR binding to an unstable insulin epitope drives type 1 diabetes
Class: immune system
Keywords: Immunoglobulin, H-2Kd, Type 1 Diabetes, Immune System
Deposited on
2015-04-06, released
2015-06-24
The last revision prior to the SCOPe 2.08 freeze date was dated
2015-08-12, with a file datestamp of
2015-08-07.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.25
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: H-2 class I histocompatibility antigen, K-D alpha chain
Species: Mus musculus [TaxId:10090]
Gene: H2-K1, H2-K
Database cross-references and differences (RAF-indexed):
- Uniprot P01902 (1-275)
- initiating methionine (0)
- conflict (114)
- expression tag (276)
Domains in SCOPe 2.08: d4z78a1, d4z78a2, d4z78a3 - Chain 'B':
Compound: Beta-2-microglobulin
Species: Homo sapiens [TaxId:9606]
Gene: B2M, CDABP0092, HDCMA22P
Database cross-references and differences (RAF-indexed):
- Uniprot P61769 (1-99)
- initiating methionine (0)
Domains in SCOPe 2.08: d4z78b1, d4z78b2 - Chain 'C':
Compound: insulin
Species: Homo sapiens [TaxId:9606]
Gene: INS
Database cross-references and differences (RAF-indexed):
- Chain 'D':
Compound: H-2 class I histocompatibility antigen, K-D alpha chain
Species: Mus musculus [TaxId:10090]
Gene: H2-K1, H2-K
Database cross-references and differences (RAF-indexed):
- Uniprot P01902 (1-275)
- initiating methionine (0)
- conflict (114)
- expression tag (276)
Domains in SCOPe 2.08: d4z78d1, d4z78d2, d4z78d3 - Chain 'E':
Compound: Beta-2-microglobulin
Species: Homo sapiens [TaxId:9606]
Gene: B2M, CDABP0092, HDCMA22P
Database cross-references and differences (RAF-indexed):
- Uniprot P61769 (1-99)
- initiating methionine (0)
Domains in SCOPe 2.08: d4z78e1, d4z78e2 - Chain 'F':
Compound: insulin
Species: Homo sapiens [TaxId:9606]
Gene: INS
Database cross-references and differences (RAF-indexed):
- Chain 'G':
Compound: H-2 class I histocompatibility antigen, K-D alpha chain
Species: Mus musculus [TaxId:10090]
Gene: H2-K1, H2-K
Database cross-references and differences (RAF-indexed):
- Uniprot P01902 (1-275)
- initiating methionine (0)
- conflict (114)
- expression tag (276)
Domains in SCOPe 2.08: d4z78g1, d4z78g2, d4z78g3 - Chain 'H':
Compound: Beta-2-microglobulin
Species: Homo sapiens [TaxId:9606]
Gene: B2M, CDABP0092, HDCMA22P
Database cross-references and differences (RAF-indexed):
- Uniprot P61769 (1-99)
- initiating methionine (0)
Domains in SCOPe 2.08: d4z78h1, d4z78h2 - Chain 'I':
Compound: insulin
Species: Homo sapiens [TaxId:9606]
Gene: INS
Database cross-references and differences (RAF-indexed):
- Heterogens: EDO, GOL, SO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>4z78A (A:)
mgphslryfvtavsrpglgeprfiavgyvddtqfvrfdsdadnprfeprapwmeqegpey
weeqtqraksdeqwfrvslrtaqryynqskggshtfqrmfgcdvgsdwrllrgyhqfayd
grdyialnedlktwtaadtaalitrrkweqagdaeyyraylegecvewlrrylelgnetl
lrtdspkahvtyhprsqvdvtlrcwalgfypaditltwqlngedltqdmelvetrpagdg
tfqkwaavvvplgkeqnytchvhhkglpepltlrwkp
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>4z78B (B:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
- Chain 'C':
No sequence available.
- Chain 'D':
Sequence; same for both SEQRES and ATOM records: (download)
>4z78D (D:)
mgphslryfvtavsrpglgeprfiavgyvddtqfvrfdsdadnprfeprapwmeqegpey
weeqtqraksdeqwfrvslrtaqryynqskggshtfqrmfgcdvgsdwrllrgyhqfayd
grdyialnedlktwtaadtaalitrrkweqagdaeyyraylegecvewlrrylelgnetl
lrtdspkahvtyhprsqvdvtlrcwalgfypaditltwqlngedltqdmelvetrpagdg
tfqkwaavvvplgkeqnytchvhhkglpepltlrwkp
- Chain 'E':
Sequence; same for both SEQRES and ATOM records: (download)
>4z78E (E:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
- Chain 'F':
No sequence available.
- Chain 'G':
Sequence; same for both SEQRES and ATOM records: (download)
>4z78G (G:)
mgphslryfvtavsrpglgeprfiavgyvddtqfvrfdsdadnprfeprapwmeqegpey
weeqtqraksdeqwfrvslrtaqryynqskggshtfqrmfgcdvgsdwrllrgyhqfayd
grdyialnedlktwtaadtaalitrrkweqagdaeyyraylegecvewlrrylelgnetl
lrtdspkahvtyhprsqvdvtlrcwalgfypaditltwqlngedltqdmelvetrpagdg
tfqkwaavvvplgkeqnytchvhhkglpepltlrwkp
- Chain 'H':
Sequence; same for both SEQRES and ATOM records: (download)
>4z78H (H:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
- Chain 'I':
No sequence available.