PDB entry 4uh6

View 4uh6 on RCSB PDB site
Description: Structure of human nNOS R354A G357D mutant heme domain in complex with 3-(2-(6-Amino-4-methylpyridin-2-yl)ethyl)-5-(methyl(2-(methylamino)ethyl)amino)benzonitrile
Class: oxidoreductase
Keywords: oxidoreductase
Deposited on 2015-03-23, released 2015-07-15
The last revision prior to the SCOPe 2.05 freeze date was dated 2015-07-15, with a file datestamp of 2015-07-10.
Experiment type: XRAY
Resolution: 1.98 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Nitric oxide synthase, brain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P29475 (0-420)
      • engineered mutation (52)
      • engineered mutation (55)
    Domains in SCOPe 2.05: d4uh6a_
  • Chain 'B':
    Compound: Nitric oxide synthase, brain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P29475 (Start-420)
      • engineered mutation (52)
      • engineered mutation (55)
    Domains in SCOPe 2.05: d4uh6b_
  • Heterogens: HEM, H4B, CL, Q1T, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4uh6A (A:)
cprflkvknwetevvltdtlhlkstletgcteyicmgsimhpsqharrpedvatkdqlfp
lakefidqyyssikrfgskahmerleevnkeidttstyqlkdteliygakhawrnasrcv
griqwsklqvfdardcttahgmfnyicnhvkyatnkgnlrsaitifpqrtdgkhdfrvwn
sqliryagykqpdgstlgdpanvqfteiciqqgwkpprgrfdvlplllqangndpelfqi
ppelvlevpirhpkfewfkdlglkwyglpavsnmlleigglefsacpfsgwymgteigvr
dycdnsrynileevakkmnldmrktsslwkdqalveiniavlysfqsdkvtivdhhsate
sfikhmeneyrcrggcpadwvwivppmsgsitpvfhqemlnyrltpsfeyqpdpwnthvw
k

    Sequence, based on observed residues (ATOM records): (download) 
    >4uh6A (A:)
cprflkvknwetevvltdtlhlkstletgcteyicmgsimhpdvatkdqlfplakefidq
yyssikrfgskahmerleevnkeidttstyqlkdteliygakhawrnasrcvgriqwskl
qvfdardcttahgmfnyicnhvkyatnkgnlrsaitifpqrtdgkhdfrvwnsqliryag
ykqpdgstlgdpanvqfteiciqqgwkpprgrfdvlplllqangndpelfqippelvlev
pirhpkfewfkdlglkwyglpavsnmlleigglefsacpfsgwymgteigvrdycdnsry
nileevakkmnldmrktsslwkdqalveiniavlysfqsdkvtivdhhsatesfikhmen
eyrcrggcpadwvwivppmsgsitpvfhqemlnyrltpsfeyqpdpwnthvwk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4uh6B (B:)
cprflkvknwetevvltdtlhlkstletgcteyicmgsimhpsqharrpedvatkdqlfp
lakefidqyyssikrfgskahmerleevnkeidttstyqlkdteliygakhawrnasrcv
griqwsklqvfdardcttahgmfnyicnhvkyatnkgnlrsaitifpqrtdgkhdfrvwn
sqliryagykqpdgstlgdpanvqfteiciqqgwkpprgrfdvlplllqangndpelfqi
ppelvlevpirhpkfewfkdlglkwyglpavsnmlleigglefsacpfsgwymgteigvr
dycdnsrynileevakkmnldmrktsslwkdqalveiniavlysfqsdkvtivdhhsate
sfikhmeneyrcrggcpadwvwivppmsgsitpvfhqemlnyrltpsfeyqpdpwnthvw
k

    Sequence, based on observed residues (ATOM records): (download) 
    >4uh6B (B:)
rflkvknwetevvltdtlhlkstletgcteyicmgsimhpatkdqlfplakefidqyyss
ikrfgskahmerleevnkeidttstyqlkdteliygakhawrnasrcvgriqwsklqvfd
ardcttahgmfnyicnhvkyatnkgnlrsaitifpqrtdgkhdfrvwnsqliryagykqp
dgstlgdpanvqfteiciqqgwkpprgrfdvlplllqangndpelfqippelvlevpirh
pkfewfkdlglkwyglpavsnmlleigglefsacpfsgwymgteigvrdycdnsrynile
evakkmnldmrktsslwkdqalveiniavlysfqsdkvtivdhhsatesfikhmeneyrc
rggcpadwvwivppmsgsitpvfhqemlnyrltpsfeyqpdpwnthvwk