PDB entry 4u1a

View 4u1a on RCSB PDB site
Description: Crystal structure of human peroxisomal delta3,delta2, enoyl-CoA isomerase helix-10 deletion mutant (ISOB-ECI2)
Class: isomerase
Keywords: PECI, crotonase, beta-oxidation, isomerase
Deposited on 2014-07-15, released 2014-12-24
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-02-25, with a file datestamp of 2015-02-20.
Experiment type: XRAY
Resolution: 2.85 Å
R-factor: 0.179
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Enoyl-CoA delta isomerase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ECI2, DRS1, HCA88, PECI
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4u1aa_
  • Chain 'B':
    Compound: Enoyl-CoA delta isomerase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ECI2, DRS1, HCA88, PECI
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75521 (23-End)
      • expression tag (22)
    Domains in SCOPe 2.06: d4u1ab1, d4u1ab2
  • Chain 'C':
    Compound: Enoyl-CoA delta isomerase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ECI2, DRS1, HCA88, PECI
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75521 (23-End)
      • expression tag (17-22)
    Domains in SCOPe 2.06: d4u1ac1, d4u1ac2
  • Heterogens: CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4u1aA (A:)
mhhhhhhssgvdlgtenlyfqsmgfetlvvtsedgitkimfnrpkkknaintemyheimr
alkaaskddsiitvltgngdyyssgndltnftdippggveekaknnavllrefvgcfidf
pkpliavvngpavgisvtllglfdavyasdratfhtpfshlgqspegcssytfpkimspa
katemlifgkkltageacaqglvtevfpdstfqkevwtrlkafaklppnalriskevirk
rereklhavnaeecnvlqgrwlsdectnav

    Sequence, based on observed residues (ATOM records): (download) 
    >4u1aA (A:)
gfetlvvtsedgitkimfnrpkkknaintemyheimralkaaskddsiitvltgngdyys
sgndltnftdippggveekaknnavllrefvgcfidfpkpliavvngpavgisvtllglf
davyasdratfhtpfshlgqspegcssytfpkimspakatemlifgkkltageacaqglv
tevfpdstfqkevwtrlkafaklppnalriskevirkrereklhavnaeecnvlqgrwls
dec

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4u1aB (B:)
mhhhhhhssgvdlgtenlyfqsmgfetlvvtsedgitkimfnrpkkknaintemyheimr
alkaaskddsiitvltgngdyyssgndltnftdippggveekaknnavllrefvgcfidf
pkpliavvngpavgisvtllglfdavyasdratfhtpfshlgqspegcssytfpkimspa
katemlifgkkltageacaqglvtevfpdstfqkevwtrlkafaklppnalriskevirk
rereklhavnaeecnvlqgrwlsdectnav

    Sequence, based on observed residues (ATOM records): (download) 
    >4u1aB (B:)
mgfetlvvtsedgitkimfnrpkkknaintemyheimralkaaskddsiitvltgngdyy
ssgndltnftdippggveekaknnavllrefvgcfidfpkpliavvngpavgisvtllgl
fdavyasdratfhtpfshlgqspegcssytfpkimspakatemlifgkkltageacaqgl
vtevfpdstfqkevwtrlkafaklppnalriskevirkrereklhavnaeecnvlqgrwl
sdec

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4u1aC (C:)
mhhhhhhssgvdlgtenlyfqsmgfetlvvtsedgitkimfnrpkkknaintemyheimr
alkaaskddsiitvltgngdyyssgndltnftdippggveekaknnavllrefvgcfidf
pkpliavvngpavgisvtllglfdavyasdratfhtpfshlgqspegcssytfpkimspa
katemlifgkkltageacaqglvtevfpdstfqkevwtrlkafaklppnalriskevirk
rereklhavnaeecnvlqgrwlsdectnav

    Sequence, based on observed residues (ATOM records): (download) 
    >4u1aC (C:)
lyfqsmgfetlvvtsedgitkimfnrpkkknaintemyheimralkaaskddsiitvltg
ngdyyssgndltnftdippggveekaknnavllrefvgcfidfpkpliavvngpavgisv
tllglfdavyasdratfhtpfshlgqspegcssytfpkimspakatemlifgkkltagea
caqglvtevfpdstfqkevwtrlkafaklppnalriskevirkrereklhavnaeecnvl
qgrwlsdect