PDB entry 4rx5

View 4rx5 on RCSB PDB site
Description: Bruton's tyrosine kinase (BTK) with pyridazinone compound 23
Class: transferase
Keywords: protein kinase, phosphotransfer catalyst, TRANSFERASE
Deposited on 2014-12-08, released 2015-12-02
The last revision prior to the SCOPe 2.05 freeze date was dated 2015-12-02, with a file datestamp of 2015-11-27.
Experiment type: XRAY
Resolution: 1.36 Å
R-factor: N/A
AEROSPACI score: 0.56 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase BTK
    Species: Homo sapiens [TaxId:9606]
    Gene: BTK, AGMX1, ATK, BPK
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06187 (Start-265)
      • expression tag (266)
    Domains in SCOPe 2.05: d4rx5a_
  • Heterogens: SO4, GOL, PG0, 3YO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4rx5A (A:)
mgsweidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsedefieeakvmmn
lsheklvqlygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdvceamey
leskqflhrdlaarnclvndqgvvkvsdfglsryvlddeytssvgskfpvrwsppevlmy
skfssksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlyrphlasekvytimy
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    Sequence, based on observed residues (ATOM records): (download) 
    >4rx5A (A:)
sweidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsedefieeakvmmnls
heklvqlygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdvceameyle
skqflhrdlaarnclvndqgvvkvsdfglsryvlddeytssvgskfpvrwsppevlmysk
fssksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlyrphlasekvytimysc
whekaderptfkillsnildvmden