PDB entry 4ra0

View 4ra0 on RCSB PDB site
Description: An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis
Class: signaling protein
Keywords: Axl, Gas6, cancer, metastasis, SIGNALING PROTEIN
Deposited on 2014-09-09, released 2014-09-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 3.07 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Growth arrest-specific protein 6
    Species: Homo sapiens [TaxId:9606]
    Gene: GAS6, AXLLG
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Growth arrest-specific protein 6
    Species: Homo sapiens [TaxId:9606]
    Gene: GAS6, AXLLG
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: tyrosine-protein kinase receptor ufo
    Species: Homo sapiens [TaxId:9606]
    Gene: AXL, UFO
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30530
      • conflict (6)
      • conflict (61)
      • conflict (66)
      • conflict (101)
    Domains in SCOPe 2.08: d4ra0c1, d4ra0c2
  • Chain 'D':
    Compound: tyrosine-protein kinase receptor ufo
    Species: Homo sapiens [TaxId:9606]
    Gene: AXL, UFO
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30530
      • conflict (6)
      • conflict (61)
      • conflict (66)
      • conflict (101)
    Domains in SCOPe 2.08: d4ra0d1, d4ra0d2
  • Heterogens: CA, CL, NI, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4ra0C (C:)
eespfvsnpgnitgargltgtlrcqlqvqgeppevhwlrdgqileladstqtqvplgede
qgdwivasqlritslqlsdtgqyqclvflghqtfvsqpgyvrleglpyfleepedrtvaa
ntpfnlscqaqgppepvdllwlqdavplatapghgpqrslhvpglnktssfsceahnakg
vttsrtatitvlpqq

    Sequence, based on observed residues (ATOM records): (download) 
    >4ra0C (C:)
espfvsnpgnitgargltgtlrcqlqvqgeppevhwlrdgqileladstqtqvplgedeq
gdwivasqlritslqlsdtgqyqclvflghqtfvsqpgyvrleglpyfleepedrtvaan
tpfnlscqaqgppepvdllwlqdavplatapghgpqrslhvpglnktssfsceahnakgv
ttsrtatitvl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4ra0D (D:)
eespfvsnpgnitgargltgtlrcqlqvqgeppevhwlrdgqileladstqtqvplgede
qgdwivasqlritslqlsdtgqyqclvflghqtfvsqpgyvrleglpyfleepedrtvaa
ntpfnlscqaqgppepvdllwlqdavplatapghgpqrslhvpglnktssfsceahnakg
vttsrtatitvlpqq

    Sequence, based on observed residues (ATOM records): (download) 
    >4ra0D (D:)
espfvsnpgnitgargltgtlrcqlqvqgeppevhwlrdgqileladstqtqvplgedeq
gdwivasqlritslqlsdtgqyqclvflghqtfvsqpgyvrleglpyfleepedrtvaan
tpfnlscqaqgppepvdllwlqdavplatapghgpqrslhvpglnktssfsceahnakgv
ttsrtatitvl