PDB entry 4nru

View 4nru on RCSB PDB site
Description: Murine Norovirus RNA-dependent-RNA-polymerase in complex with Compound 6, a suramin derivative
Class: viral protein/transcription inhibitor
Keywords: RNA dependent RNA polymerase, Murine Norovirus, VIRAL PROTEIN-TRANSCRIPTION INHIBITOR complex
Deposited on 2013-11-27, released 2014-10-15
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-10-15, with a file datestamp of 2014-10-10.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.194
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RNA dependent RNA polymerase
    Species: Murine norovirus 1 [TaxId:223997]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4nrua_
  • Chain 'B':
    Compound: RNA dependent RNA polymerase
    Species: Murine norovirus 1 [TaxId:223997]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4nrub_
  • Chain 'C':
    Compound: RNA dependent RNA polymerase
    Species: Murine norovirus 1 [TaxId:223997]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4nruc_
  • Chain 'D':
    Compound: RNA dependent RNA polymerase
    Species: Murine norovirus 1 [TaxId:223997]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4nrud_
  • Chain 'E':
    Compound: RNA dependent RNA polymerase
    Species: Murine norovirus 1 [TaxId:223997]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4nrue_
  • Chain 'F':
    Compound: RNA dependent RNA polymerase
    Species: Murine norovirus 1 [TaxId:223997]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4nruf_
  • Heterogens: 2NG, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4nruA (A:)
mlprpsgtyaglpiadygdapplstktmfwrtspeklppgawepaylgskdervdgpslq
qvmrdqlkpyseprgllppqeildavcdaienrlentlepqkpwtfkkacesldkntssg
ypyhkqkskdwtgsafigdlgdqathannmyemgksmrpiytaalkdelvkpdkiygkik
krllwgsdlgtmiraarafgpfcdalketcifnpirvgmsmnedgpfifarhanfryhmd
adytrwdstqqrailkragdimvrlspepdlarvvmddllapslldvgdykivveeglps
gcpcttqlnslahwiltlcamvevtrvdpdivmqesefsfygddevvstnleldmvkytm
alrrygllptradkeegplerrqtlqgisflrraivgdqfgwygrldrasidrqllwtkg
pnhqnpfetlpghaqrpsqlmallgeaamhgekyyrtvasrvskeaaqsgiemvvprhrs
vlrwvrfgtmdaetpqersavfvnedelehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4nruA (A:)
prpsgtyaglpiadygdapplstktmfwrtspeklppgawepaylgskdervdgpslqqv
mrdqlkpyseprgllppqeildavcdaienrlentlepqkpwtfkkacesldkntssgyp
yhkqkskdwtgsafigdlgdqathannmyemgksmrpiytaalkdelvkpdkiygkikkr
llwgsdlgtmiraarafgpfcdalketcifnpirvgmsmnedgpfifarhanfryhmdad
ytrwdstqqrailkragdimvrlspepdlarvvmddllapslldvgdykivveeglpsgc
pcttqlnslahwiltlcamvevtrvdpdivmqesefsfygddevvstnleldmvkytmal
rrygllptradkeegplerrqtlqgisflrraivgdqfgwygrldrasidrqllwtkgpn
hqnpfetlpghrpsqlmallgeaamhgekyyrtvasrvskeavvprhrsvlrwvrfg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4nruB (B:)
mlprpsgtyaglpiadygdapplstktmfwrtspeklppgawepaylgskdervdgpslq
qvmrdqlkpyseprgllppqeildavcdaienrlentlepqkpwtfkkacesldkntssg
ypyhkqkskdwtgsafigdlgdqathannmyemgksmrpiytaalkdelvkpdkiygkik
krllwgsdlgtmiraarafgpfcdalketcifnpirvgmsmnedgpfifarhanfryhmd
adytrwdstqqrailkragdimvrlspepdlarvvmddllapslldvgdykivveeglps
gcpcttqlnslahwiltlcamvevtrvdpdivmqesefsfygddevvstnleldmvkytm
alrrygllptradkeegplerrqtlqgisflrraivgdqfgwygrldrasidrqllwtkg
pnhqnpfetlpghaqrpsqlmallgeaamhgekyyrtvasrvskeaaqsgiemvvprhrs
vlrwvrfgtmdaetpqersavfvnedelehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4nruB (B:)
prpsgtyaglpiadygdapplstktmfwrtspeklppgawepaylgskdervdgpslqqv
mrdqlkpyseprgllppqeildavcdaienrlentlepqkpwtfkkacesldkntssgyp
yhkqkskdwtgsafigdlgdqathannmyemgksmrpiytaalkdelvkpdkiygkikkr
llwgsdlgtmiraarafgpfcdalketcifnpirvgmsmnedgpfifarhanfryhmdad
ytrwdstqqrailkragdimvrlspepdlarvvmddllapslldvgdykivveeglpsgc
pcttqlnslahwiltlcamvevtrvdpdivmqesefsfygddevvstnleldmvkytmal
rrygllptradkeegplerrqtlqgisflrraivgdqfgwygrldrasidrqllwtkgpn
hqnpfetlpghqrpsqlmallgeaamhgekyyrtvasrvskeaaqsgvvprhrsvlrwvr
fg

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4nruC (C:)
mlprpsgtyaglpiadygdapplstktmfwrtspeklppgawepaylgskdervdgpslq
qvmrdqlkpyseprgllppqeildavcdaienrlentlepqkpwtfkkacesldkntssg
ypyhkqkskdwtgsafigdlgdqathannmyemgksmrpiytaalkdelvkpdkiygkik
krllwgsdlgtmiraarafgpfcdalketcifnpirvgmsmnedgpfifarhanfryhmd
adytrwdstqqrailkragdimvrlspepdlarvvmddllapslldvgdykivveeglps
gcpcttqlnslahwiltlcamvevtrvdpdivmqesefsfygddevvstnleldmvkytm
alrrygllptradkeegplerrqtlqgisflrraivgdqfgwygrldrasidrqllwtkg
pnhqnpfetlpghaqrpsqlmallgeaamhgekyyrtvasrvskeaaqsgiemvvprhrs
vlrwvrfgtmdaetpqersavfvnedelehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4nruC (C:)
prpsgtyaglpiadygdapplstktmfwrtspeklppgawepaylgskdervdgpslqqv
mrdqlkpyseprgllppqeildavcdaienrlentlepqkpwtfkkacesldkntssgyp
yhkqkskdwtgsafigdlgdqathannmyemgksmrpiytaalkdelvkpdkiygkikkr
llwgsdlgtmiraarafgpfcdalketcifnpirvgmsmnedgpfifarhanfryhmdad
ytrwdstqqrailkragdimvrlspepdlarvvmddllapslldvgdykivveeglpsgc
pcttqlnslahwiltlcamvevtrvdpdivmqesefsfygddevvstnleldmvkytmal
rrygllptradkeegplerrqtlqgisflrraivgdqfgwygrldrasidrqllwtkgpn
hqnpfetlpghaqrpsqlmallgeaamhgekyyrtvasrvskevvprhrsvlrwvrfg

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4nruD (D:)
mlprpsgtyaglpiadygdapplstktmfwrtspeklppgawepaylgskdervdgpslq
qvmrdqlkpyseprgllppqeildavcdaienrlentlepqkpwtfkkacesldkntssg
ypyhkqkskdwtgsafigdlgdqathannmyemgksmrpiytaalkdelvkpdkiygkik
krllwgsdlgtmiraarafgpfcdalketcifnpirvgmsmnedgpfifarhanfryhmd
adytrwdstqqrailkragdimvrlspepdlarvvmddllapslldvgdykivveeglps
gcpcttqlnslahwiltlcamvevtrvdpdivmqesefsfygddevvstnleldmvkytm
alrrygllptradkeegplerrqtlqgisflrraivgdqfgwygrldrasidrqllwtkg
pnhqnpfetlpghaqrpsqlmallgeaamhgekyyrtvasrvskeaaqsgiemvvprhrs
vlrwvrfgtmdaetpqersavfvnedelehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4nruD (D:)
rpsgtyaglpiadygdapplstktmfwrtspeklppgawepaylgskdervdgpslqqvm
rdqlkpyseprgllppqeildavcdaienrlentlepqkpwtfkkacesldkntssgypy
hkqkskdwtgsafigdlgdqathannmyemgksmrpiytaalkdelvkpdkiygkikkrl
lwgsdlgtmiraarafgpfcdalketcifnpirvgmsmnedgpfifarhanfryhmdady
trwdstqqrailkragdimvrlspepdlarvvmddllapslldvgdykivveeglpsgcp
cttqlnslahwiltlcamvevtrvdpdivmqesefsfygddevvstnleldmvkytmalr
rygllptradkeegplerrqtlqgisflrraivgdqfgwygrldrasidrqllwtkgpnh
qnpfetlpgqrpsqlmallgeaamhgekyyrtvasrvskeaaqsvvprhrsvlrwvrfg

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4nruE (E:)
mlprpsgtyaglpiadygdapplstktmfwrtspeklppgawepaylgskdervdgpslq
qvmrdqlkpyseprgllppqeildavcdaienrlentlepqkpwtfkkacesldkntssg
ypyhkqkskdwtgsafigdlgdqathannmyemgksmrpiytaalkdelvkpdkiygkik
krllwgsdlgtmiraarafgpfcdalketcifnpirvgmsmnedgpfifarhanfryhmd
adytrwdstqqrailkragdimvrlspepdlarvvmddllapslldvgdykivveeglps
gcpcttqlnslahwiltlcamvevtrvdpdivmqesefsfygddevvstnleldmvkytm
alrrygllptradkeegplerrqtlqgisflrraivgdqfgwygrldrasidrqllwtkg
pnhqnpfetlpghaqrpsqlmallgeaamhgekyyrtvasrvskeaaqsgiemvvprhrs
vlrwvrfgtmdaetpqersavfvnedelehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4nruE (E:)
rpsgtyaglpiadygdapplstktmfwrtspeklppgawepaylgskdervdgpslqqvm
rdqlkpyseprgllppqeildavcdaienrlentlepqkpwtfkkacesldkntssgypy
hkqkskdwtgsafigdlgdqathannmyemgksmrpiytaalkdelvkpdkiygkikkrl
lwgsdlgtmiraarafgpfcdalketcifnpirvgmsmnedgpfifarhanfryhmdady
trwdstqqrailkragdimvrlspepdlarvvmddllapslldvgdykivveeglpsgcp
cttqlnslahwiltlcamvevtrvdpdivmqesefsfygddevvstnleldmvkytmalr
rygllptradkeegplerrqtlqgisflrraivgdqfgwygrldrasidrqllwtkgpnh
qnpfetlpghqrpsqlmallgeaamhgekyyrtvasrvskeavvprhrsvlrwvrfg

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4nruF (F:)
mlprpsgtyaglpiadygdapplstktmfwrtspeklppgawepaylgskdervdgpslq
qvmrdqlkpyseprgllppqeildavcdaienrlentlepqkpwtfkkacesldkntssg
ypyhkqkskdwtgsafigdlgdqathannmyemgksmrpiytaalkdelvkpdkiygkik
krllwgsdlgtmiraarafgpfcdalketcifnpirvgmsmnedgpfifarhanfryhmd
adytrwdstqqrailkragdimvrlspepdlarvvmddllapslldvgdykivveeglps
gcpcttqlnslahwiltlcamvevtrvdpdivmqesefsfygddevvstnleldmvkytm
alrrygllptradkeegplerrqtlqgisflrraivgdqfgwygrldrasidrqllwtkg
pnhqnpfetlpghaqrpsqlmallgeaamhgekyyrtvasrvskeaaqsgiemvvprhrs
vlrwvrfgtmdaetpqersavfvnedelehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4nruF (F:)
rpsgtyaglpiadygdapplstktmfwrtspeklppgawepaylgskdervdgpslqqvm
rdqlkpyseprgllppqeildavcdaienrlentlepqkpwtfkkacesldkntssgypy
hkqkskdwtgsafigdlgdqathannmyemgksmrpiytaalkdelvkpdkiygkikkrl
lwgsdlgtmiraarafgpfcdalketcifnpirvgmsmnedgpfifarhanfryhmdady
trwdstqqrailkragdimvrlspepdlarvvmddllapslldvgdykivveeglpsgcp
cttqlnslahwiltlcamvevtrvdpdivmqesefsfygddevvstnleldmvkytmalr
rygllptradkeegplerrqtlqgisflrraivgdqfgwygrldrasidrqllwtkgpnh
qnpfetlpgpsqlmallgeaamhgekyyrtvasrvskevvprhrsvlrwvrfg