PDB entry 4m4y

View 4m4y on RCSB PDB site
Description: Crystal structure of a 2009 H1N1 influenza virus hemagglutinin with a stabilization mutation HA2 E47G
Class: viral protein
Keywords: viral envelope protein, viral fusion protein, stabilization mutant, VIRAL PROTEIN
Deposited on 2013-08-07, released 2013-09-25
The last revision prior to the SCOPe 2.04 freeze date was dated 2013-11-06, with a file datestamp of 2013-11-01.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.182
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Hemagglutinin HA1 subunit
    Species: Influenza A virus [TaxId:641501]
    Gene: HA, hemagglutinin
    Database cross-references and differences (RAF-indexed):
    • Uniprot C3W5S1 (4-End)
      • expression tag (3)
    Domains in SCOPe 2.04: d4m4ya_
  • Chain 'B':
    Compound: Hemagglutinin HA2 subunit
    Species: Influenza A virus [TaxId:641501]
    Gene: HA, hemagglutinin
    Database cross-references and differences (RAF-indexed):
    • Uniprot C3W5S1 (0-173)
      • engineered mutation (46)
      • expression tag (174)
    Domains in SCOPe 2.04: d4m4yb_
  • Chain 'C':
    Compound: Hemagglutinin HA1 subunit
    Species: Influenza A virus [TaxId:641501]
    Gene: HA, hemagglutinin
    Database cross-references and differences (RAF-indexed):
    • Uniprot C3W5S1 (4-End)
      • expression tag (3)
    Domains in SCOPe 2.04: d4m4yc_
  • Chain 'D':
    Compound: Hemagglutinin HA2 subunit
    Species: Influenza A virus [TaxId:641501]
    Gene: HA, hemagglutinin
    Database cross-references and differences (RAF-indexed):
    • Uniprot C3W5S1 (0-End)
      • engineered mutation (46)
    Domains in SCOPe 2.04: d4m4yd_
  • Chain 'E':
    Compound: Hemagglutinin HA1 subunit
    Species: Influenza A virus [TaxId:641501]
    Gene: HA, hemagglutinin
    Database cross-references and differences (RAF-indexed):
    • Uniprot C3W5S1 (4-End)
      • expression tag (1-3)
    Domains in SCOPe 2.04: d4m4ye_
  • Chain 'F':
    Compound: Hemagglutinin HA2 subunit
    Species: Influenza A virus [TaxId:641501]
    Gene: HA, hemagglutinin
    Database cross-references and differences (RAF-indexed):
    • Uniprot C3W5S1 (0-End)
      • engineered mutation (46)
    Domains in SCOPe 2.04: d4m4yf_
  • Heterogens: NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4m4yA (A:)
adpgdtlcigyhannstdtvdtvleknvtvthsvnlledkhngklcklrgvaplhlgkcn
iagwilgnpeceslstasswsyivetpssdngtcypgdfidyeelreqlssvssferfei
fpktsswpnhdsnkgvtaacphagaksfyknliwlvkkgnsypklsksyindkgkevlvl
wgihhpstsadqqslyqnadtyvfvgssryskkfkpeiairpkvrdqegrmnyywtlvep
gdkitfeatgnlvvpryafamernagsgiiisdtpvhdcnttcqtpkgaintslpfqnih
pitigkcpkyvkstklrlatglrnipsiqsr

    Sequence, based on observed residues (ATOM records): (download) 
    >4m4yA (A:)
gdtlcigyhannstdtvdtvleknvtvthsvnlledkhngklcklrgvaplhlgkcniag
wilgnpeceslstasswsyivetpssdngtcypgdfidyeelreqlssvssferfeifpk
tsswpnhdsnkgvtaacphagaksfyknliwlvkkgnsypklsksyindkgkevlvlwgi
hhpstsadqqslyqnadtyvfvgssryskkfkpeiairpkvrdqegrmnyywtlvepgdk
itfeatgnlvvpryafamernagsgiiisdtpvhdcnttcqtpkgaintslpfqnihpit
igkcpkyvkstklrlatglrnips

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4m4yB (B:)
glfgaiagfieggwtgmvdgwygyhhqneqgsgyaadlkstqnaidgitnkvnsviekmn
tqftavgkefnhlekrienlnkkvddgfldiwtynaellvllenertldyhdsnvknlye
kvrsqlknnakeigngcfefyhkcdntcmesvkngtydypkyseeaklnreeidsgr

    Sequence, based on observed residues (ATOM records): (download) 
    >4m4yB (B:)
glfgaiagfieggwtgmvdgwygyhhqneqgsgyaadlkstqnaidgitnkvnsviekmn
tqftavgkefnhlekrienlnkkvddgfldiwtynaellvllenertldyhdsnvknlye
kvrsqlknnakeigngcfefyhkcdntcmesvkngtydypkyseeaklnreeids

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4m4yC (C:)
adpgdtlcigyhannstdtvdtvleknvtvthsvnlledkhngklcklrgvaplhlgkcn
iagwilgnpeceslstasswsyivetpssdngtcypgdfidyeelreqlssvssferfei
fpktsswpnhdsnkgvtaacphagaksfyknliwlvkkgnsypklsksyindkgkevlvl
wgihhpstsadqqslyqnadtyvfvgssryskkfkpeiairpkvrdqegrmnyywtlvep
gdkitfeatgnlvvpryafamernagsgiiisdtpvhdcnttcqtpkgaintslpfqnih
pitigkcpkyvkstklrlatglrnipsiqsr

    Sequence, based on observed residues (ATOM records): (download) 
    >4m4yC (C:)
gdtlcigyhannstdtvdtvleknvtvthsvnlledkhngklcklrgvaplhlgkcniag
wilgnpeceslstasswsyivetpssdngtcypgdfidyeelreqlssvssferfeifpk
tsswpnhdsnkgvtaacphagaksfyknliwlvkkgnsypklsksyindkgkevlvlwgi
hhpstsadqqslyqnadtyvfvgssryskkfkpeiairpkvrdqegrmnyywtlvepgdk
itfeatgnlvvpryafamernagsgiiisdtpvhdcnttcqtpkgaintslpfqnihpit
igkcpkyvkstklrlatglrnip

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4m4yD (D:)
glfgaiagfieggwtgmvdgwygyhhqneqgsgyaadlkstqnaidgitnkvnsviekmn
tqftavgkefnhlekrienlnkkvddgfldiwtynaellvllenertldyhdsnvknlye
kvrsqlknnakeigngcfefyhkcdntcmesvkngtydypkyseeaklnreeidsgr

    Sequence, based on observed residues (ATOM records): (download) 
    >4m4yD (D:)
glfgaiagfieggwtgmvdgwygyhhqneqgsgyaadlkstqnaidgitnkvnsviekmn
tqftavgkefnhlekrienlnkkvddgfldiwtynaellvllenertldyhdsnvknlye
kvrsqlknnakeigngcfefyhkcdntcmesvkngtydypkyseeaklnre

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4m4yE (E:)
adpgdtlcigyhannstdtvdtvleknvtvthsvnlledkhngklcklrgvaplhlgkcn
iagwilgnpeceslstasswsyivetpssdngtcypgdfidyeelreqlssvssferfei
fpktsswpnhdsnkgvtaacphagaksfyknliwlvkkgnsypklsksyindkgkevlvl
wgihhpstsadqqslyqnadtyvfvgssryskkfkpeiairpkvrdqegrmnyywtlvep
gdkitfeatgnlvvpryafamernagsgiiisdtpvhdcnttcqtpkgaintslpfqnih
pitigkcpkyvkstklrlatglrnipsiqsr

    Sequence, based on observed residues (ATOM records): (download) 
    >4m4yE (E:)
dpgdtlcigyhannstdtvdtvleknvtvthsvnlledkhngklcklrgvaplhlgkcni
agwilgnpeceslstasswsyivetpssdngtcypgdfidyeelreqlssvssferfeif
pktsswpnhdsnkgvtaacphagaksfyknliwlvkkgnsypklsksyindkgkevlvlw
gihhpstsadqqslyqnadtyvfvgssryskkfkpeiairpkvrdqegrmnyywtlvepg
dkitfeatgnlvvpryafamernagsgiiisdtpvhdcnttcqtpkgaintslpfqnihp
itigkcpkyvkstklrlatglrnips

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4m4yF (F:)
glfgaiagfieggwtgmvdgwygyhhqneqgsgyaadlkstqnaidgitnkvnsviekmn
tqftavgkefnhlekrienlnkkvddgfldiwtynaellvllenertldyhdsnvknlye
kvrsqlknnakeigngcfefyhkcdntcmesvkngtydypkyseeaklnreeidsgr

    Sequence, based on observed residues (ATOM records): (download) 
    >4m4yF (F:)
glfgaiagfieggwtgmvdgwygyhhqneqgsgyaadlkstqnaidgitnkvnsviekmn
tqftavgkefnhlekrienlnkkvddgfldiwtynaellvllenertldyhdsnvknlye
kvrsqlknnakeigngcfefyhkcdntcmesvkngtydypkyseeaklnre