PDB entry 2yme

View 2yme on RCSB PDB site
Description: Crystal structure of a mutant binding protein (5HTBP-AChBP) in complex with granisetron
Class: receptor
Keywords: receptor, pentameric ligand-gated ion channel
Deposited on 2012-10-09, released 2012-12-26
The last revision prior to the SCOPe 2.05 freeze date was dated 2013-01-30, with a file datestamp of 2013-01-25.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.1724
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8 (0-204)
      • conflict (40)
      • engineered mutation (52)
      • conflict (54)
      • conflict (135)
    Domains in SCOPe 2.05: d2ymea_
  • Chain 'B':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8 (0-204)
      • conflict (40)
      • engineered mutation (52)
      • conflict (54)
      • conflict (135)
    Domains in SCOPe 2.05: d2ymeb_
  • Chain 'C':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8 (0-204)
      • conflict (40)
      • engineered mutation (52)
      • conflict (54)
      • conflict (135)
    Domains in SCOPe 2.05: d2ymec_
  • Chain 'D':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8 (0-204)
      • conflict (40)
      • engineered mutation (52)
      • conflict (54)
      • conflict (135)
    Domains in SCOPe 2.05: d2ymed_
  • Chain 'E':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8 (0-204)
      • conflict (40)
      • engineered mutation (52)
      • conflict (54)
      • conflict (135)
    Domains in SCOPe 2.05: d2ymee_
  • Chain 'F':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8 (0-204)
      • conflict (40)
      • engineered mutation (52)
      • conflict (54)
      • conflict (135)
    Domains in SCOPe 2.05: d2ymef_
  • Chain 'G':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8 (0-204)
      • conflict (40)
      • engineered mutation (52)
      • conflict (54)
      • conflict (135)
    Domains in SCOPe 2.05: d2ymeg_
  • Chain 'H':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8 (0-204)
      • conflict (40)
      • engineered mutation (52)
      • conflict (54)
      • conflict (135)
    Domains in SCOPe 2.05: d2ymeh_
  • Chain 'I':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8 (0-204)
      • conflict (40)
      • engineered mutation (52)
      • conflict (54)
      • conflict (135)
    Domains in SCOPe 2.05: d2ymei_
  • Chain 'J':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8 (0-204)
      • conflict (40)
      • engineered mutation (52)
      • conflict (54)
      • conflict (135)
    Domains in SCOPe 2.05: d2ymej_
  • Heterogens: NAG, CWB, PO4, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2ymeA (A:)
qanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkvdsstnevdlvywerqrwkl
nslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthdgsvmfipaqr
lsfmcdptgvdseegvtcavkfgswvysgfeidlktdtdqvdlssyyasskyeilsatqt
rqvqhysccpepyidvnlvvkfrer

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2ymeB (B:)
qanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkvdsstnevdlvywerqrwkl
nslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthdgsvmfipaqr
lsfmcdptgvdseegvtcavkfgswvysgfeidlktdtdqvdlssyyasskyeilsatqt
rqvqhysccpepyidvnlvvkfrer

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2ymeC (C:)
qanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkvdsstnevdlvywerqrwkl
nslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthdgsvmfipaqr
lsfmcdptgvdseegvtcavkfgswvysgfeidlktdtdqvdlssyyasskyeilsatqt
rqvqhysccpepyidvnlvvkfrer

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2ymeD (D:)
qanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkvdsstnevdlvywerqrwkl
nslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthdgsvmfipaqr
lsfmcdptgvdseegvtcavkfgswvysgfeidlktdtdqvdlssyyasskyeilsatqt
rqvqhysccpepyidvnlvvkfrer

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2ymeE (E:)
qanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkvdsstnevdlvywerqrwkl
nslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthdgsvmfipaqr
lsfmcdptgvdseegvtcavkfgswvysgfeidlktdtdqvdlssyyasskyeilsatqt
rqvqhysccpepyidvnlvvkfrer

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2ymeF (F:)
qanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkvdsstnevdlvywerqrwkl
nslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthdgsvmfipaqr
lsfmcdptgvdseegvtcavkfgswvysgfeidlktdtdqvdlssyyasskyeilsatqt
rqvqhysccpepyidvnlvvkfrer

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2ymeG (G:)
qanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkvdsstnevdlvywerqrwkl
nslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthdgsvmfipaqr
lsfmcdptgvdseegvtcavkfgswvysgfeidlktdtdqvdlssyyasskyeilsatqt
rqvqhysccpepyidvnlvvkfrer

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2ymeH (H:)
qanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkvdsstnevdlvywerqrwkl
nslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthdgsvmfipaqr
lsfmcdptgvdseegvtcavkfgswvysgfeidlktdtdqvdlssyyasskyeilsatqt
rqvqhysccpepyidvnlvvkfrer

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2ymeI (I:)
qanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkvdsstnevdlvywerqrwkl
nslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthdgsvmfipaqr
lsfmcdptgvdseegvtcavkfgswvysgfeidlktdtdqvdlssyyasskyeilsatqt
rqvqhysccpepyidvnlvvkfrer

  • Chain 'J':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2ymeJ (J:)
qanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkvdsstnevdlvywerqrwkl
nslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthdgsvmfipaqr
lsfmcdptgvdseegvtcavkfgswvysgfeidlktdtdqvdlssyyasskyeilsatqt
rqvqhysccpepyidvnlvvkfrer