PDB entry 2y8l

View 2y8l on RCSB PDB site
Description: Structure of an active form of mammalian AMPK in complex with two ADP
Class: transferase
Keywords: transferase, nucleotide-binding, serine/threonine-protein kinase
Deposited on 2011-02-07, released 2011-03-16
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-01-22, with a file datestamp of 2014-01-17.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.229
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 5'-amp-activated protein kinase catalytic subunit alpha-1
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P54645 (18-166)
      • cloning artifact (15-17)
      • cloning artifact (167-172)
    Domains in SCOPe 2.05: d2y8la_
  • Chain 'B':
    Compound: 5'-amp-activated protein kinase subunit beta-2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2y8lb_
  • Chain 'E':
    Compound: 5'-amp-activated protein kinase subunit gamma-1
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2y8le1, d2y8le2
  • Heterogens: ADP, AMP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2y8lA (A:)
mshhhhhhsglvprgsmawhlgirsqsrpndimaevcraikqldyewkvvnpyylrvrrk
npvtstfskmslqlyqvdsrtylldfrsiddeiteaksgtatpqrsgsisnyrscqrsds
daeaqgkpsevsltssvtsldsspvdvaprpgshtieffemcanliknsctvn

    Sequence, based on observed residues (ATOM records): (download) 
    >2y8lA (A:)
smawhlgirsqsrpndimaevcraikqldyewkvvnpyylrvrrknpvtstfskmslqly
qvdsrtylldfrsiddevaprpgshtieffemcanliknsctvn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2y8lB (B:)
mgpygqemyafrseerfksppilpphllqvilnkdtniscdpallpepnhvmlnhlyals
ikdsvmvlsathrykkkyvttllykpi

    Sequence, based on observed residues (ATOM records): (download) 
    >2y8lB (B:)
gqemyafrseerfksppilpphllqvilnpnhvmlnhlyalsikdsvmvlsathrykkky
vttllykpi

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2y8lE (E:)
mesvaaesapapenehsqetpesnssvyttfmkshrcydliptssklvvfdtslqvkkaf
falvtngvraaplwdskkqsfvgmltitdfinilhryyksalvqiyeleehkietwrevy
lqdsfkplvcispnaslfdavsslirnkihrlpvidpesgntlyilthkrilkflklfit
efpkpefmsksleelqigtyaniamvrtttpvyvalgifvqhrvsalpvvdekgrvvdiy
skfdvinlaaektynnldvsvtkalqhrshyfegvlkcylhetleaiinrlveaevhrlv
vvdehdvvkgivslsdilqalvltggekkp

    Sequence, based on observed residues (ATOM records): (download) 
    >2y8lE (E:)
snssvyttfmkshrcydliptssklvvfdtslqvkkaffalvtngvraaplwdskkqsfv
gmltitdfinilhryyksalvqiyeleehkietwrevylqdsfkplvcispnaslfdavs
slirnkihrlpvidpesgntlyilthkrilkflklfitefpkpefmsksleelqigtyan
iamvrtttpvyvalgifvqhrvsalpvvdekgrvvdiyskfdvinlaaektynnldvsvt
kalqhrshyfegvlkcylhetleaiinrlveaevhrlvvvdehdvvkgivslsdilqalv
ltgge