PDB entry 2hw5

View 2hw5 on RCSB PDB site
Description: The crystal structure of human enoyl-coenzyme A (CoA) hydratase short chain 1, ECHS1
Class: lyase
Keywords: fatty acid metabolism, hydratase/isomerase superfamily, Beta-oxidation, CoA, enoyl-CoA hydratase, lyase, Structural Genomics, Structural Genomics Consortium, SGC
Deposited on 2006-07-31, released 2006-08-22
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.55 Å
R-factor: 0.216
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: enoyl-coa hydratase
    Species: Homo sapiens [TaxId:9606]
    Gene: ECHS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30084 (Start-285)
      • variant (70)
    Domains in SCOPe 2.06: d2hw5a_
  • Chain 'B':
    Compound: enoyl-coa hydratase
    Species: Homo sapiens [TaxId:9606]
    Gene: ECHS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30084 (Start-285)
      • variant (70)
    Domains in SCOPe 2.06: d2hw5b_
  • Chain 'C':
    Compound: enoyl-coa hydratase
    Species: Homo sapiens [TaxId:9606]
    Gene: ECHS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30084 (Start-285)
      • variant (70)
    Domains in SCOPe 2.06: d2hw5c_
  • Chain 'D':
    Compound: enoyl-coa hydratase
    Species: Homo sapiens [TaxId:9606]
    Gene: ECHS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30084 (Start-285)
      • variant (70)
    Domains in SCOPe 2.06: d2hw5d_
  • Chain 'E':
    Compound: enoyl-coa hydratase
    Species: Homo sapiens [TaxId:9606]
    Gene: ECHS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30084 (Start-285)
      • variant (70)
    Domains in SCOPe 2.06: d2hw5e_
  • Chain 'F':
    Compound: enoyl-coa hydratase
    Species: Homo sapiens [TaxId:9606]
    Gene: ECHS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30084 (Start-285)
      • variant (70)
    Domains in SCOPe 2.06: d2hw5f_
  • Heterogens: MG, COO

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2hw5A (A:)
mhhhhhhssgvdlgtenlyfqsmasganfeyiiaekrgknntvgliqlnrpkalnalcdg
lidelnqalkifeedpavgaivltggdkafaagadikemqnlsfqdcysskflkhwdhlt
qvkkpviaavngyafgggcelammcdiiyagekaqfaqpeiligtipgaggtqrltravg
kslamemvltgdrisaqdakqaglvskicpvetlveeaiqcaekiasnskivvamakesv
naafemtltegsklekklfystfatddrkegmtafvekrkanfkdq

    Sequence, based on observed residues (ATOM records): (download) 
    >2hw5A (A:)
anfeyiiaekrgknntvgliqlnrpkalnalcdglidelnqalkifeedpavgaivltgg
dkafaagadikemqnlsfqdcysskflkhwdhltqvkkpviaavngyafgggcelammcd
iiyagekaqfaqpeiligtipgaggtqrltravgkslamemvltgdrisaqdakqaglvs
kicpvetlveeaiqcaekiasnskivvamakesvnaafemtltegsklekklfystfatd
drkegmtafvekrkanfkdq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2hw5B (B:)
mhhhhhhssgvdlgtenlyfqsmasganfeyiiaekrgknntvgliqlnrpkalnalcdg
lidelnqalkifeedpavgaivltggdkafaagadikemqnlsfqdcysskflkhwdhlt
qvkkpviaavngyafgggcelammcdiiyagekaqfaqpeiligtipgaggtqrltravg
kslamemvltgdrisaqdakqaglvskicpvetlveeaiqcaekiasnskivvamakesv
naafemtltegsklekklfystfatddrkegmtafvekrkanfkdq

    Sequence, based on observed residues (ATOM records): (download) 
    >2hw5B (B:)
anfeyiiaekrgknntvgliqlnrpkalnalcdglidelnqalkifeedpavgaivltgg
dkafaagadikemqnlsfqdcysskflkhwdhltqvkkpviaavngyafgggcelammcd
iiyagekaqfaqpeiligtipgaggtqrltravgkslamemvltgdrisaqdakqaglvs
kicpvetlveeaiqcaekiasnskivvamakesvnaafemtltegsklekklfystfatd
drkegmtafvekrkanfkdq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2hw5C (C:)
mhhhhhhssgvdlgtenlyfqsmasganfeyiiaekrgknntvgliqlnrpkalnalcdg
lidelnqalkifeedpavgaivltggdkafaagadikemqnlsfqdcysskflkhwdhlt
qvkkpviaavngyafgggcelammcdiiyagekaqfaqpeiligtipgaggtqrltravg
kslamemvltgdrisaqdakqaglvskicpvetlveeaiqcaekiasnskivvamakesv
naafemtltegsklekklfystfatddrkegmtafvekrkanfkdq

    Sequence, based on observed residues (ATOM records): (download) 
    >2hw5C (C:)
anfeyiiaekrgknntvgliqlnrpkalnalcdglidelnqalkifeedpavgaivltgg
dkafaagadikemqnlsfqdcysskflkhwdhltqvkkpviaavngyafgggcelammcd
iiyagekaqfaqpeiligtipgaggtqrltravgkslamemvltgdrisaqdakqaglvs
kicpvetlveeaiqcaekiasnskivvamakesvnaafemtltegsklekklfystfatd
drkegmtafvekrkanfkdq

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2hw5D (D:)
mhhhhhhssgvdlgtenlyfqsmasganfeyiiaekrgknntvgliqlnrpkalnalcdg
lidelnqalkifeedpavgaivltggdkafaagadikemqnlsfqdcysskflkhwdhlt
qvkkpviaavngyafgggcelammcdiiyagekaqfaqpeiligtipgaggtqrltravg
kslamemvltgdrisaqdakqaglvskicpvetlveeaiqcaekiasnskivvamakesv
naafemtltegsklekklfystfatddrkegmtafvekrkanfkdq

    Sequence, based on observed residues (ATOM records): (download) 
    >2hw5D (D:)
anfeyiiaekrgknntvgliqlnrpkalnalcdglidelnqalkifeedpavgaivltgg
dkafaagadikemqnlsfqdcysskflkhwdhltqvkkpviaavngyafgggcelammcd
iiyagekaqfaqpeiligtipgaggtqrltravgkslamemvltgdrisaqdakqaglvs
kicpvetlveeaiqcaekiasnskivvamakesvnaafemtltegsklekklfystfatd
drkegmtafvekrkanfkdq

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2hw5E (E:)
mhhhhhhssgvdlgtenlyfqsmasganfeyiiaekrgknntvgliqlnrpkalnalcdg
lidelnqalkifeedpavgaivltggdkafaagadikemqnlsfqdcysskflkhwdhlt
qvkkpviaavngyafgggcelammcdiiyagekaqfaqpeiligtipgaggtqrltravg
kslamemvltgdrisaqdakqaglvskicpvetlveeaiqcaekiasnskivvamakesv
naafemtltegsklekklfystfatddrkegmtafvekrkanfkdq

    Sequence, based on observed residues (ATOM records): (download) 
    >2hw5E (E:)
anfeyiiaekrgknntvgliqlnrpkalnalcdglidelnqalkifeedpavgaivltgg
dkafaagadikemqnlsfqdcysskflkhwdhltqvkkpviaavngyafgggcelammcd
iiyagekaqfaqpeiligtipgaggtqrltravgkslamemvltgdrisaqdakqaglvs
kicpvetlveeaiqcaekiasnskivvamakesvnaafemtltegsklekklfystfatd
drkegmtafvekrkanfkdq

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >2hw5F (F:)
mhhhhhhssgvdlgtenlyfqsmasganfeyiiaekrgknntvgliqlnrpkalnalcdg
lidelnqalkifeedpavgaivltggdkafaagadikemqnlsfqdcysskflkhwdhlt
qvkkpviaavngyafgggcelammcdiiyagekaqfaqpeiligtipgaggtqrltravg
kslamemvltgdrisaqdakqaglvskicpvetlveeaiqcaekiasnskivvamakesv
naafemtltegsklekklfystfatddrkegmtafvekrkanfkdq

    Sequence, based on observed residues (ATOM records): (download) 
    >2hw5F (F:)
anfeyiiaekrgknntvgliqlnrpkalnalcdglidelnqalkifeedpavgaivltgg
dkafaagadikemqnlsfqdcysskflkhwdhltqvkkpviaavngyafgggcelammcd
iiyagekaqfaqpeiligtipgaggtqrltravgkslamemvltgdrisaqdakqaglvs
kicpvetlveeaiqcaekiasnskivvamakesvnaafemtltegsklekklfystfatd
drkegmtafvekrkanfkdq