PDB entry 2ary

View 2ary on RCSB PDB site
Description: Catalytic domain of Human Calpain-1
Class: hydrolase
Keywords: cysteine protease, papain, calcium-dependent, thiol protease, hydrolase,structural genomics consortium, sgc
Deposited on 2005-08-22, released 2005-08-30
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.222
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Calpain-1 catalytic subunit
    Species: Homo sapiens [TaxId:9606]
    Gene: CAPN1, CANPL1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2arya1
  • Chain 'B':
    Compound: Calpain-1 catalytic subunit
    Species: Homo sapiens [TaxId:9606]
    Gene: CAPN1, CANPL1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2aryb1
  • Heterogens: CA, BME, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2aryA (A:)
mgsshhhhhhssglvprgsgrhenaikylgqdyeqlrvrclqsgtlfrdeafppvpqslg
ykdlgpnssktygikwkrptellsnpqfivdgatrtdicqgalgdcwllaaiasltlndt
llhrvvphgqsfqngyagifhfqlwqfgewvdvvvddllpikdgklvfvhsaegnefwsa
llekayakvngsyealsggstsegfedftggvtewyelrkapsdlyqiilkalergsllg
csidissvldmeaitfkklvkghaysvtgakqvnyrgqvvslirmrnpwgevewtgawsd
sssewnnvdpyerdqlrvkmedgefwmsfrdfmreftrleicnltpdalks

    Sequence, based on observed residues (ATOM records): (download) 
    >2aryA (A:)
naikylgqdyeqlrvrclqsgtlfrdeafppvpqslgykdlgpnssktygikwkrptell
snpqfivdgatrtdicqgalgdcwllaaiasltlndtllhrvvphgqsfqngyagifhfq
lwqfgewvdvvvddllpikdgklvfvhsaegnefwsallekayakvngsyealsggstse
gfedftggvtewyelrkapsdlyqiilkalergsllgcsidissvldmeaitfkklvkgh
aysvtgakqvnyrgqvvslirmrnpwgevewtgawsdsssewnnvdpyerdqlrvkmedg
efwmsfrdfmreftrleicnlt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2aryB (B:)
mgsshhhhhhssglvprgsgrhenaikylgqdyeqlrvrclqsgtlfrdeafppvpqslg
ykdlgpnssktygikwkrptellsnpqfivdgatrtdicqgalgdcwllaaiasltlndt
llhrvvphgqsfqngyagifhfqlwqfgewvdvvvddllpikdgklvfvhsaegnefwsa
llekayakvngsyealsggstsegfedftggvtewyelrkapsdlyqiilkalergsllg
csidissvldmeaitfkklvkghaysvtgakqvnyrgqvvslirmrnpwgevewtgawsd
sssewnnvdpyerdqlrvkmedgefwmsfrdfmreftrleicnltpdalks

    Sequence, based on observed residues (ATOM records): (download) 
    >2aryB (B:)
naikylgqdyeqlrvrclqsgtlfrdeafppvpqslgykdlgpnssktygikwkrptell
snpqfivdgatrtdicqgalgdcwllaaiasltlndtllhrvvphgqsfqngyagifhfq
lwqfgewvdvvvddllpikdgklvfvhsaegnefwsallekayakvngsyealsggstse
gfedftggvtewyelrkapsdlyqiilkalergsllgcsidissvldmeaitfkklvkgh
aysvtgakqvnyrgqvvslirmrnpwgevewtgawsdsssewnnvdpyerdqlrvkmedg
efwmsfrdfmreftrleicnlt